diff --git a/packages/reactivity/src/effect.ts b/packages/reactivity/src/effect.ts
index b8dd62a0f6e..10226a0ebd1 100644
--- a/packages/reactivity/src/effect.ts
+++ b/packages/reactivity/src/effect.ts
@@ -412,6 +412,7 @@ function removeSub(link: Link) {
   if (dep.subs === link) {
     // was previous tail, point new tail to prev
     dep.subs = prevSub
+    if (__DEV__ && prevSub === undefined) dep.subsHead = undefined
   }
 
   if (!dep.subs && dep.computed) {