Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Add a gene-disease edge to rules? #270

Open
cbizon opened this issue Aug 13, 2024 · 1 comment
Open

Add a gene-disease edge to rules? #270

cbizon opened this issue Aug 13, 2024 · 1 comment
Assignees

Comments

@cbizon
Copy link
Contributor

cbizon commented Aug 13, 2024

We have a number of rules that are of the form (chemical)<-(gene)->(chemical)-treats->(disease).

There's a disease and it's treated by a chemical and some gene has a common effect on these things. So given that commonality, maybe the first chemical also treats the disease.

These rules are found by the rule engine, they have some predictive power but

  1. the power is not high
  2. They're not mechanistic for some users

I think we can improve these rules in both ways by adding an edge from the gene to the disease. I think it can be a related to.

NCATSTranslator/Feedback#465

@capasfield
Copy link
Collaborator

Chris wants to test.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Projects
None yet
Development

No branches or pull requests

2 participants