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simulateCLE.m
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simulateCLE.m
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function X = simulateCLE(numRealizations,dose,intrinsicNoise,extrinsicNoise,model)
%SIMULATECLE Simulates Chemical Langevin Equation model obtained from
% Sun et al. (2016) [BMC Systems Biology].
%
% SIMULATECLE(numRealizations,dose,noise,model) produces dynamics
% pertaining to the glioma differentiation model. numRealizations
% indicates the number of cells/dynamics to expect. dose is the CT dose
% expected. intrinsic and extrinsic noise are the noise levels expected.
%
K = numRealizations;
output = model.States.Outputs;
Nx = numel(output);
h = model.Time.Step;
tspan = model.Time.Duration(1):h:model.Time.Duration(2);
params = model.Parameters.Values;
X0 = model.States.X0;
X = zeros(Nx*numel(tspan),K);
% Iterate over individual cells
for k = 1:K
y = X0;
X(1,k) = y(output);
step = 0;
GWnoise=randn((1+max(tspan))*100,22);
paramsk = params +randn(1,39)*extrinsicNoise;
for p=h:h:max(tspan)
step = step + 1;
y = y + CLEdet(y,paramsk,dose)*h+sqrt(h)*intrinsicNoise*CLEsto(y,paramsk,dose,step,GWnoise);
y(y<0) = 0;
y(y>3) = 3;
X(step+1,k) = real(y(output));
end
end