flybase_controlled_vocabulary.obo

format-version: 1.2
data-version: 2024-08-08
date: 08:08:2024 13:54
subsetdef: camcur "camcur"
subsetdef: common_tool_use "Terms to summarize typical use of a gene from one organism that is introduced into another organism primarily for use an experimental tool, rather than to study the function of the gene"
subsetdef: do_not_annotate "Term not to be used for direct annotation"
subsetdef: do_not_manually_annotate "Term not to be used for direct manual annotation"
subsetdef: fbcvsubset_mgiribbons "MGI ribbon terms"
subsetdef: lethal_phase "lethal phase terms"
default-namespace: FlyBase miscellaneous CV
idspace: dc http://purl.org/dc/elements/1.1/ 
idspace: oboInOwl http://www.geneontology.org/formats/oboInOwl# 
idspace: terms http://purl.org/dc/terms/ 
ontology: fbcv/fbcv-simple

[Term]
id: FBcv:0000000
name: FlyBase CV
def: "FlyBase miscellaneous controlled vocabulary term." []

[Term]
id: FBcv:0000001
name: obsolete death certificate
namespace: pub_type
comment: This term was obsoleted because it was only ever used to annotate one publication: A copy of Calvin Bridges death certificate. This can still be found in the Drosophila offprint collection (FBrf0186653).
is_obsolete: true

[Term]
id: FBcv:0000002
name: abnormal thermotaxis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in thermotaxis (GO:0043052). 'thermotaxis' is defined as: 'The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.'" [FBC:DOS, GOC:cab1, WB_REF:cgc467]
synonym: "thermotaxis behavior defective" EXACT []
synonym: "thermotaxis behaviour defective" EXACT []
synonym: "thermotaxis defective" EXACT []
is_a: FBcv:0000683 ! abnormal temperature response

[Term]
id: FBcv:0000003
name: obsolete In transgenic Drosophila (intraspecific)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000004
name: obsolete Whole-organism transient assay (intraspecific)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000005
name: qualifier
def: "Term used to qualify a descriptor." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000000 ! FlyBase CV

[Term]
id: FBcv:0000006
name: male semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000375 ! semi-fertile
is_a: FBcv:0000376 ! male fertile

[Term]
id: FBcv:0000007
name: female semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000375 ! semi-fertile
is_a: FBcv:0000377 ! female fertile

[Term]
id: FBcv:0000008
name: modifier of variegation
namespace: phenotypic_class
def: "Genotype g1 is a modifier of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is significantly different from that caused by g2 alone." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "variegation" RELATED [FBC:DOS]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000009
name: obsolete temporal stage qualifier
namespace: temporal_qualifier
comment: This term has been obsoleted because all of its children terms have been obsoleted [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000010
name: obsolete monophasic
comment: This term has been obsoleted because there are new terms to replace it [FBC:MMC]. mc160113
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000011
name: obsolete relative temporal qualifier
namespace: temporal_qualifier
comment: This term has been obsoleted because all of its children terms have been obsoleted [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000012
name: obsolete absolute temporal qualifier
comment: This term has been obsoleted because both of its children terms have been obsoleted [FBC:MMC]. mc160113
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000013
name: descriptor
def: "Term that describes an allele, balancer, group or publication." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000000 ! FlyBase CV

[Term]
id: FBcv:0000014
name: structural qualifier
namespace: structural_qualifier
def: "Qualifier used to describe changes in number or location of an anatomical structure compared to wild type." [FBC:CP, FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000015
name: obsolete postage stamp
namespace: pub_type
comment: This term was obsoleted because it was little used.
is_obsolete: true

[Term]
id: FBcv:0000016
name: obsolete Baylor TE recombination mapping kit stock
comment: Consider - FBsv:0000605.
is_obsolete: true

[Term]
id: FBcv:0000017
name: obsolete penetrance qualifier
def: "Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000018
name: obsolete penetrance complete
def: "Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is complete when all the individuals of a given genotype exhibit the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000019
name: obsolete penetrance incomplete
def: "Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is incomplete when only some the individuals of a given genotype exhibit the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000020
name: obsolete penetrance percent
def: "Penetrance is the fraction of individuals of a given genotype who exhibit the phenotype associated with that genotype. Penetrance is incomplete when only a percentage of the individuals of a given genotype exhibit the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
comment: This term should be modified by a % value. This is not currently possible in FlyBase curation.
is_obsolete: true

[Term]
id: FBcv:0000021
name: obsolete expressivity qualifier
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000022
name: obsolete expressivity complete
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. Expressivity is complete when an individual of a given genotype expresses the full phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000023
name: obsolete expressivity incomplete
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. Expressivity is incomplete when an individual of a given genotype expresses only partially the phenotype associated with that genotype." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000024
name: obsolete expressivity high
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. 'High expressivity' conveys that while expressivity is not complete, the phenotype expressed is approaching that of complete expressivity." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000025
name: obsolete expressivity low
def: "Expressivity measures the extent to which a given genotype is expressed at the phenotypic level. 'Low expressivity' conveys that phenotype expressed is a much reduced version compared to complete expressivity." [ISBN:978-0-7167-3520-5]
is_obsolete: true

[Term]
id: FBcv:0000026
name: obsolete recessive visible allele recombination mapping stock
is_obsolete: true

[Term]
id: FBcv:0000027
name: obsolete dominant visible allele recombination mapping stock
is_obsolete: true

[Term]
id: FBcv:0000028
name: obsolete SNP recombination mapping stock
comment: Consider - FBsv:0001018.
is_obsolete: true

[Term]
id: FBcv:0000029
name: obsolete transposable element mutagenesis stock
is_obsolete: true

[Term]
id: FBcv:0000030
name: obsolete compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000031
name: obsolete anterior compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000032
name: obsolete compartment boundary
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000033
name: obsolete anterior/posterior compartment boundary
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000034
name: obsolete dorsal/ventral compartment boundary
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000035
name: obsolete dorsal compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000036
name: obsolete posterior compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000037
name: obsolete ventral compartment
namespace: spatial_qualifier
comment: This term was obsoleted because a term from the anatom ontology (FBbt) should be used instead. If possible, please use 'developmental compartment' (FBbt:00007110) or one of its subclasses [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000038
name: relative spatial qualifier
namespace: spatial_qualifier
def: "Qualifier that describes the spatial characteristics of a phenotype or expression pattern relative to the position of another entity." [FBC:CP]
subset: do_not_annotate
xref: PATO:0001631
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000039
name: anterior to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front of an organism relative to another entity." [PATO:0001632]
xref: PATO:0001632
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000040
name: distal to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located further from a more centrally located entity." [PATO:0001234]
xref: PATO:0001234
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000041
name: dorsal to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the back or upper surface of an organism relative to another entity." [PATO:0001233]
xref: PATO:0001233
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000042
name: obsolete deficiency kit stock
synonym: "deletion kit stock" RELATED []
is_obsolete: true

[Term]
id: FBcv:0000043
name: obsolete transposase source for transposable element mutagenesis
comment: Consider - FBsv:0001020.
is_obsolete: true

[Term]
id: FBcv:0000044
name: obsolete ammunition source for transposable element mutagenesis
comment: Consider - FBsv:0001022.
is_obsolete: true

[Term]
id: FBcv:0000045
name: posterior to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the rear of an organism relative to another entity." [PATO:0001633]
xref: PATO:0001633
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000046
name: precursor
namespace: temporal_qualifier
is_a: FBcv:0000176 ! temporal qualifier

[Term]
id: FBcv:0000047
name: proximal to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity." [PATO:0001195]
xref: PATO:0001195
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000048
name: surrounding
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being extended on all sides of another entity simultaneously." [PATO:0001772]
xref: PATO:0001772
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000049
name: ventral to
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located toward the belly or lower surface of an organism relative to another entity." [FBC:CP]
xref: PATO:0001196
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000050
name: vicinity of
namespace: spatial_qualifier
def: "A spatial quality inhering in a bearer by virtue of the bearer's being located near in space in relation to another entity." [PATO:0002259]
synonym: "adjacent to" NARROW [PATO:0002259]
xref: PATO:0002259
is_a: FBcv:0000038 ! relative spatial qualifier

[Term]
id: FBcv:0000051
name: segment boundary
namespace: spatial_qualifier
def: "Present in the area that separates segments." [FBC:MMC]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000052
name: spatial qualifier
namespace: spatial_qualifier
def: "Qualifier that describes the spatial characteristics of a phenotype or expression pattern." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000053
name: anterior
namespace: spatial_qualifier
def: "Restricted to anterior region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000054
name: apical
namespace: spatial_qualifier
def: "Restricted to apical region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000055
name: basal
namespace: spatial_qualifier
def: "Restricted to basal region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000056
name: central
namespace: spatial_qualifier
def: "Restricted to central region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000057
name: obsolete contralateral
namespace: spatial_qualifier
comment: This term has been obsoleted because there is no way to combine it with an anatomy term to produce a meaningful statement [FBC:MMC]. mc160113.
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000058
name: distal
namespace: spatial_qualifier
def: "Restricted to distal region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000059
name: dorsal
namespace: spatial_qualifier
def: "Restricted to dorsal region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000060
name: dorso-lateral
namespace: spatial_qualifier
def: "Restricted to dorso-lateral region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000061
name: ectopic
namespace: structural_qualifier
def: "Anatomical structure is present in a location in which it would not be present in wild-type." [FBC:CP]
comment: An extra copy of an anatomical structure that is present in the same location as in wild-type should use 'increased number', rather than 'ectopic'.
xref: PATO:0000628
is_a: FBcv:0000014 ! structural qualifier

[Term]
id: FBcv:0000062
name: obsolete ipsilateral
namespace: spatial_qualifier
comment: This term has been obsoleted because there is no way to combine it with an anatomy term to produce a meaningful statement [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000052

[Term]
id: FBcv:0000063
name: lateral
namespace: spatial_qualifier
def: "Restricted to lateral region(s) of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000064
name: medial
namespace: spatial_qualifier
def: "Restricted to medial region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000065
name: posterior
namespace: spatial_qualifier
def: "Restricted to posterior region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000066
name: proximal
namespace: spatial_qualifier
def: "Restricted to proximal region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000067
name: restricted
namespace: spatial_qualifier
def: "Restricted to unknown part(s) of a specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000068
name: increased number
namespace: structural_qualifier
def: "Present in the correct location but in larger numbers than in wild-type." [FBC:DOS]
synonym: "supernumerary" EXACT []
is_a: FBcv:0000014 ! structural qualifier

[Term]
id: FBcv:0000069
name: ubiquitous
namespace: spatial_qualifier
def: "Expressed everywhere at some specified stage." [FBC:DOS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000070
name: ventral
namespace: spatial_qualifier
def: "Restricted to ventral region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000071
name: ventro-lateral
namespace: spatial_qualifier
def: "Restricted to ventro-lateral region of some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000072
name: obsolete gene expression qualifier
is_obsolete: true

[Term]
id: FBcv:0000073
name: obsolete embryonic expression pattern
is_obsolete: true

[Term]
id: FBcv:0000074
name: egg length
namespace: spatial_qualifier
def: "Position in the egg or pre-gastrula embryo expressed as a percentage of egg length, where 0% corresponds to the posterior tip and 100% to the anterior tip." [FBC:DOS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000075
name: 0% egg length
namespace: spatial_qualifier
def: "At the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000076
name: 0-10% egg length
namespace: spatial_qualifier
def: "0-10% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000077
name: 0-100% egg length
namespace: spatial_qualifier
def: "The full length of the pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000078
name: 0-20% egg length
namespace: spatial_qualifier
def: "0-20% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000079
name: 0-30% egg length
namespace: spatial_qualifier
def: "0-30% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000080
name: 0-40% egg length
namespace: spatial_qualifier
def: "0-40% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000081
name: 0-50% egg length
namespace: spatial_qualifier
def: "0-50% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000082
name: 0-60% egg length
namespace: spatial_qualifier
def: "0-60% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000083
name: 0-70% egg length
namespace: spatial_qualifier
def: "0-70% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000084
name: 0-80% egg length
namespace: spatial_qualifier
def: "0-80% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000085
name: 0-90% egg length
namespace: spatial_qualifier
def: "0-90% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000086
name: 10% egg length
namespace: spatial_qualifier
def: "10% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000087
name: 10-100% egg length
namespace: spatial_qualifier
def: "10-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000088
name: 10-20% egg length
namespace: spatial_qualifier
def: "10-20% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000089
name: 10-30% egg length
namespace: spatial_qualifier
def: "10-30% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000090
name: 10-40% egg length
namespace: spatial_qualifier
def: "10-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000091
name: 10-50% egg length
namespace: spatial_qualifier
def: "10-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000092
name: 10-60% egg length
namespace: spatial_qualifier
def: "10-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000093
name: 10-70% egg length
namespace: spatial_qualifier
def: "10-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000094
name: 10-80% egg length
namespace: spatial_qualifier
def: "10-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000095
name: 10-90% egg length
namespace: spatial_qualifier
def: "10-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000096
name: 100% egg length
namespace: spatial_qualifier
def: "At the anterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000097
name: 20% egg length
namespace: spatial_qualifier
def: "20% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000098
name: 20-100% egg length
namespace: spatial_qualifier
def: "20-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000099
name: 20-30% egg length
namespace: spatial_qualifier
def: "20-30% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000100
name: 20-40% egg length
namespace: spatial_qualifier
def: "20-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000101
name: 20-50% egg length
namespace: spatial_qualifier
def: "20-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000102
name: 20-60% egg length
namespace: spatial_qualifier
def: "20-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000103
name: 20-70% egg length
namespace: spatial_qualifier
def: "20-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000104
name: 20-80% egg length
namespace: spatial_qualifier
def: "20-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000105
name: 20-90% egg length
namespace: spatial_qualifier
def: "20-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000106
name: 30% egg length
namespace: spatial_qualifier
def: "30% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000107
name: 30-100% egg length
namespace: spatial_qualifier
def: "30-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000108
name: 30-40% egg length
namespace: spatial_qualifier
def: "30-40% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000109
name: 30-50% egg length
namespace: spatial_qualifier
def: "30-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000110
name: 30-60% egg length
namespace: spatial_qualifier
def: "30-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000111
name: 30-70% egg length
namespace: spatial_qualifier
def: "30-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000112
name: 30-80% egg length
namespace: spatial_qualifier
def: "30-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000113
name: 30-90% egg length
namespace: spatial_qualifier
def: "30-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000114
name: 40% egg length
namespace: spatial_qualifier
def: "40% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000115
name: 40-100% egg length
namespace: spatial_qualifier
def: "40-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000116
name: 40-50% egg length
namespace: spatial_qualifier
def: "40-50% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000117
name: 40-60% egg length
namespace: spatial_qualifier
def: "40-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000118
name: 40-70% egg length
namespace: spatial_qualifier
def: "40-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000119
name: 40-80% egg length
namespace: spatial_qualifier
def: "40-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000120
name: 40-90% egg length
namespace: spatial_qualifier
def: "40-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000121
name: 50% egg length
namespace: spatial_qualifier
def: "50% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000122
name: 50-100% egg length
namespace: spatial_qualifier
def: "50-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000123
name: 50-60% egg length
namespace: spatial_qualifier
def: "50-60% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000124
name: 50-70% egg length
namespace: spatial_qualifier
def: "50-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000125
name: 50-80% egg length
namespace: spatial_qualifier
def: "50-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000126
name: 50-90% egg length
namespace: spatial_qualifier
def: "50-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000127
name: 60% egg length
namespace: spatial_qualifier
def: "60% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000128
name: 60-100% egg length
namespace: spatial_qualifier
def: "60-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000129
name: 60-80% egg length
namespace: spatial_qualifier
def: "60-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000130
name: 60-90% egg length
namespace: spatial_qualifier
def: "60-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000131
name: 70% egg length
namespace: spatial_qualifier
def: "70% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000132
name: 70-100% egg length
namespace: spatial_qualifier
def: "70-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000133
name: 70-80% egg length
namespace: spatial_qualifier
def: "70-80% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000134
name: 70-90% egg length
namespace: spatial_qualifier
def: "70-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000135
name: 80% egg length
namespace: spatial_qualifier
def: "80% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000136
name: 80-90% egg length
namespace: spatial_qualifier
def: "80-90% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000137
name: 90% egg length
namespace: spatial_qualifier
def: "90% of egg length from the posterior tip of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000139
name: 90-100% egg length
namespace: spatial_qualifier
alt_id: FBcv:0000138
def: "90-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
synonym: "90-100% egg length" RELATED []
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000140
name: FlyBase analysis
namespace: pub_type
def: "A record of an analysis carried out by FlyBase that has not been formally published." [FBC:SM]
is_a: FBcv:0000233 ! unpublished

[Term]
id: FBcv:0000141
name: gradient
namespace: spatial_qualifier
def: "Expression pattern which varies in intensity following a gradient in a specific axis." [FBC:MMC]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000142
name: anterior posterior gradient
namespace: spatial_qualifier
def: "Expression pattern which varies in intensity following a gradient in the anterior-posterior axis." [FBC:MMC]
is_a: FBcv:0000141 ! gradient

[Term]
id: FBcv:0000143
name: dorsal ventral gradient
namespace: spatial_qualifier
def: "Expression pattern which varies in intensity following a gradient in the dorsal-ventral axis." [FBC:MMC]
is_a: FBcv:0000141 ! gradient

[Term]
id: FBcv:0000144
name: obsolete maternal pattern
is_obsolete: true

[Term]
id: FBcv:0000145
name: striped
namespace: spatial_qualifier
def: "Restricted to stripes in some specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000146
name: I-CreI
namespace: origin_of_mutation
def: "Sequence change caused by the cleavage of a 19-24 bp palindromic DNA site by the I-CreI endonuclease." [UniProt:P05725]
synonym: "change induced by I-CreI endonuclease cleavage" EXACT []
is_a: FBcv:0003007 ! site specific cleavage

[Term]
id: FBcv:0000147
name: even pair rule expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression in even, but not odd numbered segment of the blastoderm." [FBC:DOS]
is_a: FBcv:0000322 ! pair rule expression pattern

[Term]
id: FBcv:0000148
name: odd pair rule expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression in odd, but not even numbered segments of the blastoderm." [FBC:DOS]
is_a: FBcv:0000322 ! pair rule expression pattern

[Term]
id: FBcv:0000149
name: species list
namespace: pub_type
def: "A list of species found in a specified area." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000150
name: segmentally repeated
namespace: spatial_qualifier
def: "Restricted to a segmentally repeated pattern with some specified type." [FBC:DOS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000151
name: obsolete archive
namespace: pub_type
comment: This term was obsoleted because there because there were no instances of its use to classify any artefact in FlyBase.
is_obsolete: true

[Term]
id: FBcv:0000152
name: obsolete balancer stock
def: "A stock with one or more chromosomes (balancers) that are used primarily for their ability to preserve a stock genotype without selection." [FBC:KM]
comment: Consider - FBsv:0001001.
is_obsolete: true

[Term]
id: FBcv:0000153
name: cell autonomous
namespace: genotype_to_phenotype_relation
def: "A phenotypic effect which is expressed in and limited to cells of the mutant genetic constitution under investigation is said to be cell autonomous." [FlyBase:FBrf0002379]
is_a: FBcv:0000797 ! cell autonomy qualifier

[Term]
id: FBcv:0000154
name: cell non-autonomous
namespace: genotype_to_phenotype_relation
def: "A phenotypic effect which is not expressed in/limited to cells of the mutant genetic constitution under investigation is said to be cell non-autonomous." [FlyBase:FBrf0002379]
is_a: FBcv:0000797 ! cell autonomy qualifier

[Term]
id: FBcv:0000155
name: single balancer
def: "Chromosome that carries inversions and visible mutations, and which can be used to identify the genotype of an individual." [FlyBase:FBrf0089469, FlyBase:FBrf0202435]
is_a: FBcv:0000687 ! balancer descriptor

[Term]
id: FBcv:0000156
name: obsolete pair of homologous balancers
is_obsolete: true

[Term]
id: FBcv:0000157
name: obsolete recessive lethal balancer
is_obsolete: true

[Term]
id: FBcv:0000158
name: obsolete balancer for chromosome 1
comment: Consider - FBsv:0001006.
is_obsolete: true

[Term]
id: FBcv:0000159
name: obsolete balancer for chromosome 2
comment: Consider - FBsv:0001007.
is_obsolete: true

[Term]
id: FBcv:0000160
name: obsolete balancer for chromosome 3
comment: Consider - FBsv:0001008.
is_obsolete: true

[Term]
id: FBcv:0000161
name: maternal effect
namespace: genotype_to_phenotype_relation
def: "A phenotypic attribute is described as showing a maternal effect when the phenotype of an individual is a manifestation of the genotype of the mother, rather than the genotype of the individual." [ISBN:978-0-7167-3520-5]
is_a: FBcv:0000685 ! parental effect

[Term]
id: FBcv:0000162
name: non-rescuable maternal effect
namespace: genotype_to_phenotype_relation
def: "A phenotypic attribute is described as showing a non-rescuable maternal effect (strict maternal effect) when the introduction of a wild-type copy of the responsible mutation from the father has no ameliorating effect on the maternal effect mutant phenotype." [FlyBase:FBrf0049894]
is_a: FBcv:0000161 ! maternal effect

[Term]
id: FBcv:0000163
name: rescuable maternal effect
namespace: genotype_to_phenotype_relation
def: "A phenotypic attribute is described as showing a rescuable maternal effect when the introduction of a wild-type copy of the responsible mutation from the father ameliorates the maternal effect mutant phenotype." [FlyBase:FBrf0049894]
is_a: FBcv:0000161 ! maternal effect

[Term]
id: FBcv:0000164
name: paternal effect
namespace: genotype_to_phenotype_relation
def: "A phenotypic attribute is described as showing a paternal effect when the phenotype of an individual is a manifestation of the genotype of the father, rather than the genotype of the individual." [FlyBase:FBrf0102738]
is_a: FBcv:0000685 ! parental effect

[Term]
id: FBcv:0000165
name: obsolete pair of balancers for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000166
name: morphological qualifier
namespace: expression_qualifier
def: "Qualifier that describes an observed expression pattern." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000167
name: faint
namespace: expression_qualifier
def: "Weak expression." [FBC:MMC]
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000168
name: granular
namespace: expression_qualifier
def: "Expression pattern that resembles small grains or particles." [FBC:MMC]
xref: PATO:0001759
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000169
name: intense
namespace: expression_qualifier
def: "Strong expression." [FBC:MMC]
xref: PATO:0000049
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000170
name: punctate
namespace: expression_qualifier
def: "Expression pattern that resembles small dots." [FBC:MMC]
xref: PATO:0001512
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000171
name: uniform
namespace: expression_qualifier
def: "Expression pattern that is constant throughout the assayed anatomical entity." [FBC:MMC]
xref: PATO:0000438
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000172
name: variable
namespace: expression_qualifier
def: "Expression pattern that changes throughout the assayed anatomical entity." [FBC:MMC]
xref: PATO:0001227
is_a: FBcv:0000166 ! morphological qualifier

[Term]
id: FBcv:0000173
name: obsolete pair of balancers for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000174
name: obsolete dominant male sterile balancer
comment: Consider - FBsv:0001012.
is_obsolete: true

[Term]
id: FBcv:0000175
name: obsolete dominant female sterile balancer
comment: Consider - FBsv:0001012.
is_obsolete: true

[Term]
id: FBcv:0000176
name: temporal qualifier
namespace: temporal_qualifier
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000177
name: obsolete dominant female sterile balancer for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000178
name: obsolete early
namespace: temporal_qualifier
comment: This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000179
name: obsolete dominant female sterile balancer for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000180
name: obsolete dominant male sterile balancer for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000181
name: obsolete late
namespace: temporal_qualifier
comment: This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000182
name: obsolete mid
namespace: temporal_qualifier
comment: This term was obsoleted because a term from the developmental ontology (FBdv) should be used instead [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000183
name: obsolete n day
comment: This term has been obsoleted because there are new stage terms that can be used instead [FBC:MMC]. mc160113
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000184
name: obsolete n hr
comment: This term has been obsoleted because there are new stage terms that can be used instead [FBC:MMC]. mc160113
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000185
name: obsolete dominant male sterile balancer for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000186
name: obsolete recessive lethal balancer for chromosome 1
is_obsolete: true

[Term]
id: FBcv:0000187
name: obsolete recessive lethal balancer for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000188
name: publication descriptor
def: "Qualifier that describes the type of publication." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0000189
name: publication class
namespace: pub_type
def: "A publicly available document. It includes individual articles, such as research papers and reviews, and collections of articles, such as scientific journals." [FBC:DOS, FBC:SM]
subset: do_not_annotate
is_a: FBcv:0000188 ! publication descriptor

[Term]
id: FBcv:0000190
name: abstract
namespace: pub_type
def: "An individual abstract of a presentation at a meeting, congress, conference, symposium, colloquium, seminar, workshop, round table, or other professional gathering." [MeSH:D016416]
synonym: "Meeting Abstracts" EXACT [MeSH:D016416]
xref: MeSH:D016416
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000191
name: obsolete advertisement
namespace: pub_type
comment: This term was obsoleted because it only ever used to annotate a couple of publications.
is_obsolete: true

[Term]
id: FBcv:0000192
name: autobiography
namespace: pub_type
def: "A work consisting of a self-described account." [MeSH:D020493]
xref: MeSH:D020493
is_a: FBcv:0000194 ! biography

[Term]
id: FBcv:0000193
name: bibliographic list
namespace: pub_type
def: "A work consisting of a list of books, articles, documents, publications, and other items, usually on a single subject or related subjects." [MeSH:D016417]
synonym: "Bibliography" EXACT [MeSH:D016417]
xref: MeSH:D016417
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000194
name: biography
namespace: pub_type
def: "A work consisting of an account of the events, works, and achievements, personal and professional, during a person's life. This class includes articles on the activities and accomplishments of living persons as well as the presentation of an obituary." [MeSH:D019215]
xref: MeSH:D019215
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000195
name: book
namespace: pub_type
def: "A publication on a single subject or related subjects that is complete in itself, whether constructed of chapters, sections, or parts, and that is not issued on a regular, ongoing basis. Every chapter is written by the same author or authors of the publication." [FBC:SM]
comment: For books (in the common sense of the term) that have different authors for each chapter, please use 'edited book'.
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000196
name: obsolete booklet
namespace: pub_type
comment: This term was obsoleted because it was little used in curation. The formerly associated publications have mainly been annotated with other, more appropriate publication classes.
is_obsolete: true

[Term]
id: FBcv:0000197
name: book review
namespace: pub_type
def: "A work consisting of a critical analysis of one or more books or other monographic works." [MeSH:D022921]
synonym: "Book Reviews" EXACT [MeSH:D022921]
xref: MeSH:D022921
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000198
name: obsolete computer file
namespace: pub_type
synonym: "CD-ROM" RELATED []
is_obsolete: true

[Term]
id: FBcv:0000199
name: conference report
namespace: pub_type
def: "The published records of the papers delivered at or issued on the occasion of individual congresses, symposia, and meetings; abstracts of papers delivered at such congresses; reports of the officers and delegates of such congresses; combinations of the foregoing; or proceedings of the conference of a society if they are not limited to matters of internal organization." [MeSH:D016423]
comment: The definition is taken straight from the MeSH term Congresses, which PubMed uses to annotate both meeting reports written by attendees and conference abstract books. This term should therefore be used to index both of these two rather different artefacts.
synonym: "conference proceedings" NARROW []
synonym: "Congresses" EXACT [MeSH:D016423]
synonym: "meeting report" NARROW []
xref: MeSH:D016423
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000200
name: obsolete demonstration
namespace: pub_type
comment: This term was obsoleted because it was little used. All publications associated with it have been re-annotated with other publication classes.
is_obsolete: true

[Term]
id: FBcv:0000201
name: DNA/RNA sequence record
namespace: pub_type
def: "A record of a DNA or RNA sequence in some standard format, such as GenBank or EMBL or DDBJ." [FBC:DOS, FBC:SM]
is_a: FBcv:0000789 ! sequence record

[Term]
id: FBcv:0000202
name: protein sequence record
namespace: pub_type
def: "A record of a protein sequence in some standard format, such as UniProtKB." [FBC:SM]
is_a: FBcv:0000789 ! sequence record

[Term]
id: FBcv:0000203
name: erratum
namespace: pub_type
def: "A work consisting of an acknowledgement of an error, issued by a publisher, editor, or author." [MeSH:D016425]
synonym: "correction" EXACT []
synonym: "Corrigendum" EXACT [MeSH:D016425]
synonym: "Published Erratum" EXACT [MeSH:D016425]
xref: MeSH:D016425
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000204
name: film
namespace: pub_type
def: "A film or video that is factual, documentary or instructional in character." [FBC:SM, MeSH:D019499, MeSH:D019514]
synonym: "video" NARROW []
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000205
name: interview
namespace: pub_type
def: "A work consisting of a conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer." [MeSH:D017203]
xref: MeSH:D017203
is_a: FBcv:0000194 ! biography

[Term]
id: FBcv:0000206
name: obsolete jigsaw puzzle
namespace: pub_type
comment: This term was obsoleted because it only ever used to annotate one, unarchived publication.
is_obsolete: true

[Term]
id: FBcv:0000207
name: letter
namespace: pub_type
def: "A work consisting of written or printed communication between individuals or between persons and representatives of corporate bodies. The correspondence may be personal or professional." [MeSH:D016422]
comment: In medical and other scientific publications the letter is usually from one or more authors to the editor of the journal or book publishing the item being commented upon or discussed.
xref: MeSH:D016422
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000208
name: obsolete microscope slides
namespace: pub_type
comment: This term was obsoleted because it had only been used once in FlyBase, and this was for an artefact that is not present in a FlyBase associated archive. The associated record in FlyBase CHADO has been obsoleted.
is_obsolete: true

[Term]
id: FBcv:0000209
name: news article
namespace: pub_type
def: "A work consisting of an announcement or statement of recent or current events of new data and matters of interest in the field of medicine or science, published in a scientific journal." [FBC:SM, MeSH:D016433]
xref: MeSH:D016433
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000210
name: note
namespace: pub_type
def: "A work consisting of a critical or explanatory note written to discuss, support, or dispute an article or other presentation previously published." [MeSH:D016420]
synonym: "Comment" EXACT [MeSH:D016420]
xref: MeSH:D016420
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000211
name: obituary
namespace: pub_type
def: "A published announcement of a death accompanied by a short biography of the deceased." [FBC:SM]
is_a: FBcv:0000194 ! biography

[Term]
id: FBcv:0000212
name: paper
namespace: pub_type
def: "An article reporting original research, published in a peer-reviewed journal." [FBC:SM]
comment: Note that this is a much more specific class than that referred to by MeSH Journal article (D016428).
synonym: "Journal article" BROAD [MeSH:D016428]
xref: MeSH:D016428
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000213
name: patent
namespace: pub_type
def: "A work consisting of documents granted by a government giving exclusive rights to an inventor or assignee to manufacture, use, or sell an invention for a certain number of years." [MeSH:D020490]
xref: MeSH:D020490
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000214
name: personal communication to FlyBase
namespace: pub_type
def: "A work that has not been formally published and that consists of observations or data submitted by a researcher or group of researchers directly to FlyBase." [FBC:DOS, FBC:SM]
is_a: FBcv:0000233 ! unpublished

[Term]
id: FBcv:0000215
name: poem
namespace: pub_type
def: "A literary or oral work expressing meaning via symbolism and following formal or informal patterns." [MeSH:D055821]
synonym: "poetry" EXACT [MeSH:D055821]
xref: MeSH:D055821
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000216
name: poster
namespace: pub_type
def: "A work consisting of a single or multi-sheet notice made to attract attention to events, activities, causes, goods, or services. It is for posting, usually in a public place and is chiefly pictorial. It is intended to make an immediate impression from a distance." [MeSH:D019519]
comment: The class does not encompass poster presentations at conferences and meetings.
xref: MeSH:D019519
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000217
name: press release
namespace: pub_type
def: "A written or recorded communication directed at members of the news media for the purpose of announcing something ostensibly newsworthy." [http://en.wikipedia.org/w/index.php?title=Press_release&oldid=482495713]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000218
name: obsolete recording
namespace: pub_type
comment: This term has been obsoleted because it was little used in curation and the artefacts annotated with it are not present in any FlyBase associated archive. Records annotated with this term have been obsoleted in the FlyBase CHADO database.
is_obsolete: true

[Term]
id: FBcv:0000219
name: retraction
namespace: pub_type
def: "A work consisting of a statement issued by one or more authors of an article or a book, withdrawing or disavowing acknowledgement of their participation in performing research or writing the results of their study." [MeSH:D016440]
synonym: "Retraction of Publication" EXACT [MeSH:D016440]
xref: MeSH:D016440
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000220
name: review
namespace: pub_type
def: "An article or book published after examination of published material on a subject." [MeSH:D016454]
comment: The reviews most often desired are reviews of the current literature, but a review of historical literature is also within the scope of this publication type.
xref: MeSH:D016454
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000221
name: obsolete slides
namespace: pub_type
comment: This term has been obsoleted because it was little used in curation and the artefacts annotated with it are not present in any FlyBase associated archive.
is_obsolete: true

[Term]
id: FBcv:0000222
name: spoof
namespace: pub_type
def: "A mildly satirical mockery or parody of a conventional publication type." [FBC:SM]
xref: MeSH:D020480
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000223
name: stock list
namespace: pub_type
def: "A list of Drosophila stocks kept by a specified stock center or research group." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000224
name: supplementary material
namespace: pub_type
def: "Supporting content or information, such as animation, datasets, multimedia files, video, movies, audio files, text files, or software, which is submitted for publication in an online journal or an online edition of a journal. This information may be referenced in the text of the article with a link to the supplementary data provided." [MeSH:D058537]
synonym: "additional files" EXACT []
synonym: "Electronic Supplementary Materials" EXACT [MeSH:D058537]
synonym: "supplementary information" EXACT []
synonym: "supporting information" EXACT []
xref: MeSH:D058537
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000225
name: obsolete T-shirt
namespace: pub_type
comment: This term was obsoleted because it had been used only once in ~20 years of curation.
is_obsolete: true

[Term]
id: FBcv:0000226
name: obsolete tactile diagram
namespace: pub_type
def: "A diagram that is designed to be touched, rather than looked at. These are generally made for use by blind or visually impaired people." [FBC:DOS]
is_obsolete: true

[Term]
id: FBcv:0000227
name: teaching note
namespace: pub_type
def: "An article describing exercises or practicals suitable for teaching." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000228
name: thesis
namespace: pub_type
def: "A work consisting of a formal presentation made usually to fulfill requirements for an academic degree." [MeSH:D019478]
synonym: "Academic Dissertations" EXACT [MeSH:D019478]
xref: MeSH:D019478
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000229
name: curated genome annotation
namespace: pub_type
def: "A systematic effort to annotate gene models on a sequenced Drosophila genome, such as those conducted for D. melanogaster at the Celera Jamboree. Annotations may be performed manually or automatically." [FBC:SM]
comment: Note that the name of this publication type will change to simply 'genome annotation', but this change has been delayed pending required work on the database.
synonym: "automatic genome annotation" RELATED []
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000230
name: obsolete automatic genome annotation
namespace: pub_type
comment: This term was obsoleted because it was hardly ever used. Please use FBcv:0000229 instead.
is_obsolete: true
replaced_by: FBcv:0000229

[Term]
id: FBcv:0000231
name: white paper
namespace: pub_type
def: "A work consisting of a set of statements, directions, or principles presenting current or future rules or policy." [FBC:SM, MeSH:D016431]
synonym: "Guideline" BROAD [MeSH:D016431]
xref: MeSH:D016431
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000232
name: obsolete recessive lethal balancer for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000233
name: unpublished
namespace: pub_type
def: "A work that has not been formally published." [MeSH:D022902]
synonym: "privately distributed report" RELATED []
synonym: "Unpublished Works" EXACT [MeSH:D022902]
xref: MeSH:D022902
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000234
name: publication language
namespace: language
def: "Qualifier that describes the language of the publication." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000188 ! publication descriptor

[Term]
id: FBcv:0000235
name: Afrikaans
namespace: language
def: "Publication in the Afrikaans language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000236
name: Arabic
namespace: language
def: "Publication in the Arabic language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000237
name: Armenian
namespace: language
def: "Publication in the Armenian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000238
name: Belarussian
namespace: language
def: "Publication in the Belarussian language." [FBC:MMC]
synonym: "Belarusian" RELATED []
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000239
name: Bulgarian
namespace: language
def: "Publication in the Bulgarian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000240
name: Catalan
namespace: language
def: "Publication in the Catalan language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000241
name: Chinese
namespace: language
def: "Publication in the Chinese language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000242
name: Cumbrian
namespace: language
def: "Publication in the Cumbrian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000243
name: Czech
namespace: language
def: "Publication in the Czech language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000244
name: Danish
namespace: language
def: "Publication in the Danish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000245
name: Dutch
namespace: language
def: "Publication in the Dutch language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000246
name: English
namespace: language
def: "Publication in the English language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000247
name: Estonian
namespace: language
def: "Publication in the Estonian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000248
name: Faroese
namespace: language
def: "Publication in the Faroese language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000249
name: Farsi
namespace: language
def: "Publication in the Farsi language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000250
name: Finnish
namespace: language
def: "Publication in the Finnish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000251
name: Flemish
namespace: language
def: "Publication in the Flemish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000252
name: French
namespace: language
def: "Publication in the French language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000253
name: German
namespace: language
def: "Publication in the German language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000254
name: Greek
namespace: language
def: "Publication in the Greek language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000255
name: Hebrew
namespace: language
def: "Publication in the Hebrew language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000256
name: Hungarian
namespace: language
def: "Publication in the Hungarian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000257
name: Icelandic
namespace: language
def: "Publication in the Icelandic language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000258
name: Indonesian
namespace: language
def: "Publication in the Indonesian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000259
name: Italian
namespace: language
def: "Publication in the Italian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000260
name: Japanese
namespace: language
def: "Publication in the Japanese language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000261
name: Jugoslavian
namespace: language
def: "Publication in the Jugoslavian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000262
name: Korean
namespace: language
def: "Publication in the Korean language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000263
name: Latin
namespace: language
def: "Publication in the Latin language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000264
name: Latvian
namespace: language
def: "Publication in the Latvian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000265
name: Lithuanian
namespace: language
def: "Publication in the Lithuanian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000266
name: Malay
namespace: language
def: "Publication in the Malay language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000267
name: Malayalam
namespace: language
def: "Publication in the Malayalam language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000268
name: Norwegian
namespace: language
def: "Publication in the Norwegian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000269
name: Polish
namespace: language
def: "Publication in the Polish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000270
name: Portuguese
namespace: language
def: "Publication in the Portuguese language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000271
name: Serbo-Croat(Roman)
namespace: language
def: "Publication in the Serbo-Croat (Roman) language." [FBC:MMC]
is_a: FBcv:0000274 ! Serbo-Croat

[Term]
id: FBcv:0000272
name: Romanian
namespace: language
def: "Publication in the Roman language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000273
name: Russian
namespace: language
def: "Publication in the Russian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000274
name: Serbo-Croat
namespace: language
def: "Publication in the Serbo-Croat language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000275
name: Slovak
namespace: language
def: "Publication in the Slovak language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000276
name: Slovenian
namespace: language
def: "Publication in the Slovenian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000277
name: Spanish
namespace: language
def: "Publication in the Spanish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000278
name: Swedish
namespace: language
def: "Publication in the Swedish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000279
name: Turkish
namespace: language
def: "Publication in the Turkish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000280
name: Ukrainian
namespace: language
def: "Publication in the Ukrainian language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000281
name: Yiddish
namespace: language
def: "Publication in the Yiddish language." [FBC:MMC]
is_a: FBcv:0000234 ! publication language

[Term]
id: FBcv:0000282
name: mutant scorability rank
namespace: scorability
def: "Rank that describes the usefulness of mutants according to their phenotype." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000807 ! allele descriptor

[Term]
id: FBcv:0000283
name: RK1
namespace: scorability
def: "The RK1 rank describes mutants that are easily scored." [FlyBase:FBrf0066905]
is_a: FBcv:0000282 ! mutant scorability rank

[Term]
id: FBcv:0000284
name: RK2
namespace: scorability
def: "The RK2 rank describes mutants that are usable but less convenient." [FlyBase:FBrf0066905]
is_a: FBcv:0000282 ! mutant scorability rank

[Term]
id: FBcv:0000285
name: RK3
namespace: scorability
def: "The RK3 rank describes mutants that are of limited usefulness." [FlyBase:FBrf0066905]
is_a: FBcv:0000282 ! mutant scorability rank

[Term]
id: FBcv:0000286
name: allele class
namespace: allele_class
def: "Term that describes the type of allele." [FBC:MMC]
subset: do_not_annotate
synonym: "allele morphy class" EXACT []
is_a: FBcv:0000807 ! allele descriptor

[Term]
id: FBcv:0000287
name: loss of function allele
namespace: allele_class
def: "An allele that either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." [FlyBase:FBrf0049147]
comment: Loss of function alleles are generally, but not exclusively, recessive. At haplo-insufficient loci (loci that require two copies for normal function), loss of function alleles can be dominant.
is_a: FBcv:0000286 ! allele class

[Term]
id: FBcv:0000288
name: amorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to completely lack function from the observation that addition of extra copies in the genome has no effect on the phenotype. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy)." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000688 ! amorphic allele

[Term]
id: FBcv:0000289
name: hypomorphic allele - genetic evidence
namespace: allele_class
def: "Allele inferred to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity from the observation that extra copies in the genome decrease the expressivity and/or penetrance of the phenotype. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype than the allele in trans to a deletion of the gene (1 copy))." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000690 ! hypomorphic allele

[Term]
id: FBcv:0000290
name: gain of function allele
namespace: allele_class
def: "An allele that either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type." [FlyBase:FBrf0049147]
comment: Gain of function alleles are generally dominant. But not all dominant alleles are gain of function alleles.
is_a: FBcv:0000286 ! allele class

[Term]
id: FBcv:0000291
name: neomorphic allele - genetic evidence
namespace: allele_class
def: "An allele that is inferred to make a gene product with a novel function or expression pattern compared to wild-type based on the evidence that the phenotype is unaffected by extra or fewer doses of the wild-type gene." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000697 ! neomorphic allele

[Term]
id: FBcv:0000292
name: antimorphic allele - genetic evidence
namespace: allele_class
def: "An allele that is inferred to make a gene product that is antagonistic to the wild-type gene product from the observations that extra copies of the wild-type allele reduce the expressivity and/or penetrance of the phenotype. So, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus. This test is similar to that used for hypomorphic alleles. An antimorph can be distinguished from a dominant hypermorph as only the former can be reverted to wild-type by deletion of the mutant allele." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000695 ! antimorphic allele

[Term]
id: FBcv:0000293
name: hypermorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to make either increased amounts of a normal gene product or a gene product with normal function but increased activity compared to wild-type from the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype. Most commonly this evidence takes the form of experiments showing that homozygotes (2 copies) have a stronger phenotype than transheterozygotes to a deletion of the gene (1 copy)." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000696 ! hypermorphic allele

[Term]
id: FBcv:0000294
name: wild-type allele
namespace: allele_class
def: "Allele that corresponds to the wild-type one." [FBC:MMC]
is_a: FBcv:0000286 ! allele class

[Term]
id: FBcv:0000295
name: wild-type generic
namespace: allele_class
def: "Wild-type allele that can be distinguished from others." [FBC:MMC]
is_a: FBcv:0000294 ! wild-type allele

[Term]
id: FBcv:0000296
name: isoallele
namespace: allele_class
def: "Wild-type allele that can only be distinguished from another one under special conditions." [FlyBase:FBrf0202435]
is_a: FBcv:0000294 ! wild-type allele

[Term]
id: FBcv:0000297
name: obsolete extracted wild-type chromosome 1
is_obsolete: true

[Term]
id: FBcv:0000298
name: recessive
namespace: dominance_qualifier
def: "A phenotypic attribute is described as recessive when it is manifest only in individuals homozygous or hemizygous for the allele that causes that phenotype." [ISBN:978-0-8053-0316-2]
is_a: FBcv:0000565 ! dominance relationship qualifier

[Term]
id: FBcv:0000299
name: dominant
namespace: dominance_qualifier
def: "A phenotypic attribute is described as dominant when it is manifest in individuals heterozygous for the allele that causes that phenotype." [ISBN:978-0-8053-0316-2]
is_a: FBcv:0000565 ! dominance relationship qualifier

[Term]
id: FBcv:0000300
name: codominant
namespace: dominance_qualifier
def: "A phenotypic attribute is described as codominant when it is manifest in individuals carrying the allele that causes that phenotype, irrespective of the homologous allele." [ISBN:978-0-8053-0316-2]
is_a: FBcv:0000299 ! dominant

[Term]
id: FBcv:0000301
name: semidominant
namespace: dominance_qualifier
def: "A phenotypic attribute is described as semidominant when individuals heterozygous for the allele show phenotypes part way between homozygotes for either allele." [ISBN:978-0-8053-0316-2]
is_a: FBcv:0000299 ! dominant

[Term]
id: FBcv:0000302
name: obsolete extracted wild-type chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000303
name: obsolete extracted wild-type chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000304
name: obsolete extracted wild-type chromosome 4
is_obsolete: true

[Term]
id: FBcv:0000305
name: obsolete extracted wild-type chromosome Y
is_obsolete: true

[Term]
id: FBcv:0000306
name: sex limited
namespace: sex_qualifier
def: "Expression is limited to one or other sex by virtue of the particular biology of that sex, rather than the sex-linkage of the genes underlying the attribute." [FlyBase:FBrf0075559]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000332 ! sex

[Term]
id: FBcv:0000307
name: male limited
namespace: sex_qualifier
def: "Expression is limited to males by virtue of the particular biology of males, rather than the sex-linkage of the gene(s) involved." [FlyBase:FBrf0075559]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000306 ! sex limited

[Term]
id: FBcv:0000308
name: female limited
namespace: sex_qualifier
def: "Expression is limited to females by virtue of the particular biology of females, rather than the sex-linkage of the gene(s) involved." [FlyBase:FBrf0075559]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000306 ! sex limited

[Term]
id: FBcv:0000309
name: conditional
namespace: environmental_qualifier
def: "Phenotype expressed only under specific environmental conditions that do not induce the same defect in wild-type animals." [FBC:DOS]
synonym: "conditional qualifier" RELATED []
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000310
name: temperature conditional
namespace: environmental_qualifier
def: "Phenotype only expressed in some subset of the temperature range within which wild-type animals are viable." [FBC:DOS]
is_a: FBcv:0000309 ! conditional

[Term]
id: FBcv:0000311
name: heat sensitive
namespace: environmental_qualifier
def: "Phenotype only expressed at high temperatures." [FBC:DOS]
synonym: "conditional - heat sensitive" EXACT []
synonym: "conditional ts" EXACT []
synonym: "hs" EXACT []
is_a: FBcv:0000310 ! temperature conditional

[Term]
id: FBcv:0000312
name: cold sensitive
namespace: environmental_qualifier
def: "Phenotype only expressed at low temperatures." [FBC:DOS]
synonym: "conditional - cold sensitive" EXACT []
synonym: "conditional cs" EXACT []
synonym: "cs" EXACT []
is_a: FBcv:0000310 ! temperature conditional

[Term]
id: FBcv:0000313
name: drug conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence of some specific drug (CHEBI:23888) whose presence does not induce the same defect in wild-type animals." [FBC:DOS]
is_a: FBcv:0000704 ! chemical conditional

[Term]
id: FBcv:0000314
name: RU486 conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence of RU486 (CHEBI:50692), also known as mifepristone." [FBC:DOS]
synonym: "conditional mifepristone" EXACT []
synonym: "conditional RU486" EXACT []
is_a: FBcv:0000313 ! drug conditional

[Term]
id: FBcv:0000315
name: tetracycline conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence of tetracycline (CHEBI:27902)." [FBC:DOS]
synonym: "conditional tetracycline" EXACT []
is_a: FBcv:0000313 ! drug conditional

[Term]
id: FBcv:0000316
name: homeotic
namespace: phenotypic_class
def: "Phenotype that is the partial or full transformation of one or more segments (FBbt:00000003) or segmental appendages from one identity to another. For example, in antennapedia an antenna is partially or fully transformed into a leg." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000317
name: obsolete isogenic chromosome 1
is_obsolete: true

[Term]
id: FBcv:0000318
name: obsolete isogenic chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000319
name: gap expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression across a contiguous block of two or more segments of the blastoderm." [FBC:DOS]
is_a: FBcv:0000654 ! embryonic pattern qualifier

[Term]
id: FBcv:0000320
name: terminal expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression in the terminal regions of the embryo/larva: the acron, telson and adjacent segments." [FBC:DOS]
synonym: "terminal" RELATED []
is_a: FBcv:0000654 ! embryonic pattern qualifier

[Term]
id: FBcv:0000321
name: obsolete isogenic chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000322
name: pair rule expression pattern
namespace: embryonic_pattern_qualifier
def: "Expression in alternate segments of the blastoderm." [FBC:DOS]
is_a: FBcv:0000654 ! embryonic pattern qualifier

[Term]
id: FBcv:0000323
name: segment polarity expression pattern
namespace: embryonic_pattern_qualifier
def: "Qualifier that describes an expression pattern of a segment polarity gene. Expression is observed in a specific location in each segment." [FBC:MMC]
is_a: FBcv:0000654 ! embryonic pattern qualifier

[Term]
id: FBcv:0000324
name: abnormal dorsal/ventral axis specification
namespace: phenotypic_class
def: "Phenotype that is any abnormality in dorsal/ventral axis specification (GO:0009950). 'dorsal/ventral axis specification' is defined as: 'The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.'" [FBC:DOS, GOC:dph, GOC:go_curators, GOC:tb]
synonym: "dorsal-ventral polarity" RELATED [FBC:DOS]
synonym: "dorsal/ventral axis specification defective" EXACT []
is_a: FBcv:0000686 ! abnormal axis specification

[Term]
id: FBcv:0000325
name: neurogenic phenotype
namespace: phenotypic_class
def: "A phenotype that is an expansion of the developing embryonic nervous system at the expense of developing ventral epidermis." [FlyBase:FBrf0040185]
comment: Typically this is caused by and expansion of the population of neuroblasts at the expense of prospective epidermis, both of which originate in the ventral ectoderm.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000326
name: obsolete isogenic chromosome 4
is_obsolete: true

[Term]
id: FBcv:0000327
name: obsolete P-element transposase source for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000328
name: obsolete hobo transposase source for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000329
name: obsolete piggyBac transposase source for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000330
name: obsolete minos transposase source for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000331
name: obsolete polyphasic
namespace: temporal_qualifier
comment: This term has been obsoleted because there are new terms to replace it [FBC:MMC]. mc161027
is_obsolete: true
consider: FBcv:0000176

[Term]
id: FBcv:0000332
name: sex
namespace: sex_qualifier
def: "Qualifier that relates the expression of a phenotype to the sex of the individual." [FBC:MMC]
subset: do_not_annotate
synonym: "sex qualifier" EXACT [FBC:DOS]
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000333
name: male
namespace: sex_qualifier
def: "Expressed in males." [FBC:DOS]
comment: This term has historically been used as a qualifier for expression and phenotype, but its use for phenotype has been deprecated. Its use does not imply expression exclusively in males.
is_a: FBcv:0000332 ! sex

[Term]
id: FBcv:0000334
name: female
namespace: sex_qualifier
def: "Expressed in females." [FBC:DOS]
comment: This term has historically been used as a qualifier for expression and phenotype, but its use for phenotype has been deprecated. Its use does not imply expression exclusively in females.
is_a: FBcv:0000332 ! sex

[Term]
id: FBcv:0000335
name: germline clone
namespace: clone_qualifier
def: "A clone of germline cells that share a genotype." [FBC:DOS]
synonym: "germ-line clone" EXACT []
is_a: FBcv:0000812 ! clone of cells

[Term]
id: FBcv:0000336
name: somatic clone
namespace: clone_qualifier
def: "A clone of somatic cells that share a genotype that is different from the genotype of the animal in which it resides and from which it is derived." [FBC:DOS]
is_a: FBcv:0000812 ! clone of cells

[Term]
id: FBcv:0000337
name: obsolete P-element ammunition for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000338
name: obsolete hobo ammunition for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000339
name: obsolete fully
namespace: extent
comment: DEPRECATION WARNING: This term has been obsoleted as 'fully' is assumed in the absence of use of 'partially'. mc151118
is_obsolete: true
consider: FBcv:0000811

[Term]
id: FBcv:0000340
name: partially
namespace: extent
def: "Incomplete penetrance or expressivity of a phenotype or incomplete suppression of a phenotype." [FBC:DOS]
comment: Note on usage: This qualifier should not be used in combination with lethal, viable, sterile or fertile. For these cases, terms of the form semi-X should be used instead.
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000341
name: obsolete good
namespace: intensity_qualifier
comment: This term has been obsoleted as it should be assumed a phenotype is good, unless it is said otherwise, by using other qualifiers. mc151118
is_obsolete: true
consider: FBcv:0000811

[Term]
id: FBcv:0000342
name: poor
namespace: intensity_qualifier
def: "Qualifier that describes a phenotype that has poor penetrance or expressivity." [FBC:MMC]
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000343
name: reduced
namespace: intensity_qualifier
def: "Qualifier that describes a phenotype that has reduced penetrance or expressivity when compared to wild-type." [FBC:MMC]
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000344
name: slow
namespace: intensity_qualifier
def: "Qualifier that describes an electrophoretic migration of a gene product that is slower than the wild-type." [FBC:MMC]
xref: PATO:0000304
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000345
name: fast
namespace: intensity_qualifier
def: "Qualifier that describes an electrophoretic migration of a gene product that is intermediate in speed compared to the wild-type." [FBC:MMC]
xref: PATO:0000303
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000346
name: intermediate
namespace: intensity_qualifier
def: "Qualifier that describes a phenotype that is intermediate in speed compared to the wild-type." [FBC:MMC]
comment: This qualifier can be used to describe an electrophoretic migration of a gene product that is intermediate in speed compared to the wild-type.
is_a: FBcv:0000811 ! qualitative qualifier

[Term]
id: FBcv:0000347
name: phenotypic class
namespace: phenotypic_class
subset: do_not_annotate
is_a: FBcv:0000807 ! allele descriptor

[Term]
id: FBcv:0000348
name: wild-type
namespace: phenotypic_class
def: "The canonical phenotype of a wild-type Drosophilid." [FBC:DOS]
is_a: FBcv:0000347 ! phenotypic class
disjoint_from: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000349
name: viable
namespace: phenotypic_class
def: "A phenotype that is survival to mature adulthood, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS]
comment: Note, this term should not be used with the qualifier 'partially'. Use semi-viable or semi-lethal instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000347 ! phenotypic class

[Term]
id: FBcv:0000350
name: partially lethal - majority live
namespace: phenotypic_class
def: "A phenotype of a population that is the death of some significant proportion of animals in that population, but less that half, prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS]
subset: lethal_phase
synonym: "semi-viable" EXACT []
is_a: FBcv:0000349 ! viable
is_a: FBcv:0002015 ! partially lethal

[Term]
id: FBcv:0000351
name: lethal
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS, FBC:KM]
comment: Note on usage: lethal is appropriate in cases where escaper adults are very rare. The lethal phase prior to becoming a mature adult may be further specified using children terms which specify stage.
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0000352
name: partially lethal - majority die
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a majority of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS, FBC:KM, FBC:NB]
comment: Stages during which there is significant death prior to mature adulthood can be indicated using one or more stage qualifiers.
subset: lethal_phase
synonym: "semi-lethal" EXACT []
is_a: FBcv:0002015 ! partially lethal

[Term]
id: FBcv:0000353
name: cell lethal
namespace: phenotypic_class
def: "A phenotype that is a failure of mutant cells to survive." [FBC:DOS]
comment: Typically, this phenotype is assayed in clones of cells.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000354
name: visible
namespace: phenotypic_class
def: "A post-embryonic, macroscopic, anatomical phenotype." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000355
name: abnormal eye color
namespace: phenotypic_class
def: "Phenotype that is any abnormality in eye color compared to wild-type." [FBC:DOS]
synonym: "eye color defective" EXACT []
synonym: "eye colour defective" EXACT []
is_a: FBcv:0000354 ! visible

[Term]
id: FBcv:0000356
name: abnormal body color
namespace: phenotypic_class
def: "A phenotype that is any abnormality in body color compared to wild-type." [FBC:DOS]
synonym: "body color defective" EXACT []
synonym: "body colour defective" EXACT []
is_a: FBcv:0000354 ! visible

[Term]
id: FBcv:0000357
name: abnormal size
namespace: phenotypic_class
def: "A phenotype that is any abnormality in the size of the whole body or some body part compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "size defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000358
name: decreased body size
namespace: phenotypic_class
def: "Phenotype that is a decrease in body size compared to identically raised wild-type controls." [FBC:DOS]
synonym: "reduced body size" EXACT []
synonym: "small body" EXACT []
is_a: FBcv:0000665 ! abnormal body size
is_a: FBcv:0007508 ! decreased size

[Term]
id: FBcv:0000359
name: decreased cell number
namespace: phenotypic_class
def: "Phenotype that is a decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth - there may be fewer cells in an otherwise normal volume of tissue." [FBC:DOS]
synonym: "reduced cell number" EXACT []
is_a: FBcv:0000709 ! abnormal cell number

[Term]
id: FBcv:0000360
name: decreased cell size
namespace: phenotypic_class
def: "Phenotype that is a decrease in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by decreased growth of a tissue - there may be more cells in an otherwise normal volume of tissue." [FBC:DOS]
comment: Note that defects in cell size are not necessarily the result of defects in cell growth. A change in the rate of cell division in the absence of any change in cell growth rate can result in smaller or larger cells.
synonym: "reduced cell size" EXACT []
is_a: FBcv:0000428 ! abnormal cell size

[Term]
id: FBcv:0000361
name: increased body size
namespace: phenotypic_class
def: "Phenotype that is an increase in body size compared to identically raised wild-type controls." [FBC:DOS]
synonym: "large body" EXACT []
is_a: FBcv:0000665 ! abnormal body size
is_a: FBcv:0007507 ! increased size

[Term]
id: FBcv:0000362
name: increased cell number
namespace: phenotypic_class
def: "Phenotype that is an increase in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type." [FBC:DOS]
comment: This phenotype is not necessarily accompanied by overgrowth of a tissue - there may be more cells in an otherwise normal volume of tissue. It is not necessarily due to an increase in cell growth -it may be the result of an increase in the division rate at normal growth rates. It may not even be due to an increase in the cell division rate - a reduced rate of cell death while the division rate is normal could also achieve it.
is_a: FBcv:0000709 ! abnormal cell number

[Term]
id: FBcv:0000363
name: increased cell size
namespace: phenotypic_class
def: "Phenotype that is an increase in the size of cells compared to wild-type." [FBC:DOS]
comment: May be due to an increase in the cell growth rate or to a reduced rate of cell division along with a normal rate of cell growth.
is_a: FBcv:0000428 ! abnormal cell size

[Term]
id: FBcv:0000364
name: sterile
namespace: phenotypic_class
def: "A phenotype that is the inability to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note, this term should not be used with the qualifier 'partially'. Use semi-sterile or semi-fertile instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000365
name: semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000366
name: female sterile
namespace: phenotypic_class
def: "A phenotype that is the inability of females to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note: this term should not be used with the qualifier 'partially' - use semi-sterile or semi-fertile instead.
is_a: FBcv:0000364 ! sterile

[Term]
id: FBcv:0000367
name: female semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of females to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000365 ! semi-sterile

[Term]
id: FBcv:0000368
name: female sterile germline-dependent
namespace: phenotypic_class
def: "A phenotype of female sterility due to defects in the female germline." [FBC:DOS]
synonym: "female sterile germ-line-dependent" EXACT []
is_a: FBcv:0000366 ! female sterile

[Term]
id: FBcv:0000369
name: female sterile soma-dependent
namespace: phenotypic_class
def: "A phenotype of female sterility due to defects in somatic cells of the ovary (FBbt:00006030), or of the products of these cells (such as eggshell)." [FBC:DOS]
is_a: FBcv:0000366 ! female sterile

[Term]
id: FBcv:0000370
name: male sterile
namespace: phenotypic_class
def: "A phenotype that is the inability of males to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: The cause of sterility may be physical or behavioral. Note - this term should not be used with the qualifier 'partially' - use semi-sterile or semi-fertile instead.
is_a: FBcv:0000364 ! sterile

[Term]
id: FBcv:0000371
name: male semi-sterile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability of males to produce fertilized eggs as a result of mating to below 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
is_a: FBcv:0000365 ! semi-sterile

[Term]
id: FBcv:0000372
name: male sterile germline-dependent
namespace: phenotypic_class
def: "A phenotype of male sterility due to defects in the male germline." [FBC:DOS]
synonym: "male sterile germ-line-dependent" EXACT []
is_a: FBcv:0000370 ! male sterile

[Term]
id: FBcv:0000373
name: male sterile soma-dependent
namespace: phenotypic_class
def: "A phenotype of male sterility due to defects in somatic cells of the testis (FBbt:00006031) or of the products of these cells." [FBC:DOS]
is_a: FBcv:0000370 ! male sterile

[Term]
id: FBcv:0000374
name: fertile
namespace: phenotypic_class
def: "A phenotype that is the ability to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note, this term should not be used with the qualifier 'partially'. Use semi-sterile or semi-fertile instead.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000347 ! phenotypic class

[Term]
id: FBcv:0000375
name: semi-fertile
namespace: phenotypic_class
def: "A phenotype that is a reduction in the ability to produce fertilized eggs as a result of mating, but only to > 50% of wild-type." [FBC:AO, FBC:CP, FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0000374 ! fertile
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000376
name: male fertile
namespace: phenotypic_class
def: "A phenotype that is the ability of males to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note - this term should not be used with the qualifier 'partially' - use male semi-sterile or male semi-fertile instead.
is_a: FBcv:0000374 ! fertile

[Term]
id: FBcv:0000377
name: female fertile
namespace: phenotypic_class
def: "A phenotype that is the ability of females to produce fertilized eggs as a result of mating." [FBC:AO, FBC:CP, FBC:DOS]
comment: Note - this term should not be used with the qualifier 'partially' - use female semi-sterile or female semi-fertile instead.
is_a: FBcv:0000374 ! fertile

[Term]
id: FBcv:0000378
name: grandchildless
namespace: phenotypic_class
def: "A phenotype in which all offspring are sterile. Typically, this is due to maternal effect sterility resulting from defects in pole cell development." [ISBN:978-0-87969-321-3]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000379
name: enhancer of variegation
namespace: phenotypic_class
def: "Genotype g1 is an enhancer of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is greater than that caused by g2 alone." [FBC:DOS]
comment: Typically, g2 is a chromosomal aberration or an insertion.
is_a: FBcv:0000008 ! modifier of variegation

[Term]
id: FBcv:0000380
name: non-enhancer of variegation
namespace: phenotypic_class
def: "Genotype g1 is a non-enhancer of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not greater than that caused by g2 alone." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000381
name: suppressor of variegation
namespace: phenotypic_class
def: "Genotype g1 is a suppressor of variegation if, and only if, some genotype g2 has a variegated phenotype and the degree of variegation caused by g1g2 is less than that caused by to g2 alone." [FBC:DOS]
comment: Typically, g2 is a chromosomal aberration or an insertion.
is_a: FBcv:0000008 ! modifier of variegation

[Term]
id: FBcv:0000382
name: non-suppressor of variegation
namespace: phenotypic_class
def: "Genotype g1 is a non-suppressor of variegation of the phenotype due to genotype g2 if, and only if, g2 has a variegated phenotype and the degree of variegation caused by g1g2 is not less than that caused by g2 alone." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000383
name: auxotroph
namespace: phenotypic_class
def: "A phenotype that is the inability to synthesize some organic compound that can be synthesized by wild-type animals, and that is required for normal growth and/or development." [http://en.wikipedia.org/wiki/Auxotrophic]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000384
name: abnormal aging
namespace: phenotypic_class
def: "Phenotype that is any abnormality in aging." [GOC:PO_curators]
subset: fbcvsubset_mgiribbons
synonym: "aging defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000385
name: short lived
namespace: phenotypic_class
def: "Phenotype that is a shorter adult life-span than wild-type." [FBC:DOS]
subset: lethal_phase
synonym: "increased adult mortality" EXACT []
is_a: FBcv:0002004 ! increased mortality

[Term]
id: FBcv:0000386
name: long lived
namespace: phenotypic_class
def: "Phenotype that is a longer adult life-span than wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000387
name: abnormal behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in behavior (GO:0007610). 'behavior' is defined as: 'The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.'" [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]
subset: fbcvsubset_mgiribbons
synonym: "behavior defective" EXACT []
synonym: "behavioral" RELATED []
synonym: "behaviour defective" EXACT []
synonym: "behavioural" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000388
name: abnormal gravitaxis
namespace: phenotypic_class
def: "Phenotype that is a change in the strong tendency, seen in wild-type Drosophila melanogaster, to climb - a behavior otherwise known as negative gravitaxis (GO:0048060 ; movement away from the source of gravity)." [FBC:DOS]
comment: Note, this term should not be used when flies have climbing defects purely as a consequence of locomotion defects, use 'locomotor behavior defective' instead.
subset: fbcvsubset_mgiribbons
synonym: "geotaxis behaviour defective" RELATED []
synonym: "gravitaxis behavior defective" RELATED []
synonym: "gravitaxis defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000389
name: paralytic
namespace: phenotypic_class
def: "Phenotype that is a disposition to paralysis under conditions that do not cause paralysis in a wild-type animal. Paralysis is defined as an inability to exhibit `multicellular organismal movement` (GO:0050879)" [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000390
name: decreased rate of movement
namespace: phenotypic_class
def: "A phenotype consisting of an decrease in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "hypoactive" EXACT []
synonym: "reduced rate of movement" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000391
name: bang sensitive
namespace: phenotypic_class
def: "A phenotype exhibited following mechanical shock and consisting of a brief period of intense, uncoordinated motor activity (legs and wings flailing, abdomen coiling) followed by a prolonged period of paralysis." [FlyBase:FBrf0022877]
synonym: "easily shocked" RELATED [FlyBase:FBrf0022877]
is_a: FBcv:0000389 ! paralytic

[Term]
id: FBcv:0000392
name: increased rate of movement
namespace: phenotypic_class
def: "A phenotype consisting of an increase in any kind of rate (e.g. speed, frequency) of `multicellular organismal movement` (GO:0050879) compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "hyperactive" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000393
name: abnormal pain response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to pain (GO:0048265). 'response to pain' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.'" [FBC:DOS, GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]
synonym: "pain response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000394
name: abnormal circadian rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in circadian rhythm (GO:0007623). 'circadian rhythm' is defined as: 'Any biological process in an organism that recurs with a regularity of approximately 24 hours.'" [FBC:DOS, GOC:bf, GOC:go_curators]
subset: fbcvsubset_mgiribbons
synonym: "circadian rhythm defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000395
name: abnormal locomotor rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in locomotor rhythm (GO:0045475). 'locomotor rhythm' is defined as: 'The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.'" [FBC:DOS, GOC:go_curators]
synonym: "locomotor rhythm defective" EXACT []
is_a: FBcv:0000414 ! abnormal locomotor behavior
is_a: FBcv:0000679 ! abnormal circadian behavior

[Term]
id: FBcv:0000396
name: abnormal eclosion rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in eclosion rhythm (GO:0008062). 'eclosion rhythm' is defined as: 'The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.'" [FBC:DOS, PMID:11715043]
synonym: "eclosion rhythm defective" EXACT []
is_a: FBcv:0000670 ! abnormal eclosion
is_a: FBcv:0000679 ! abnormal circadian behavior

[Term]
id: FBcv:0000397
name: abnormal learning
namespace: phenotypic_class
def: "Phenotype that is any abnormality in learning (GO:0007612). 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.'" [FBC:DOS, ISBN:0582227089, ISBN:0721662544]
synonym: "learning defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000398
name: abnormal memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in memory (GO:0007613). 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).'" [FBC:DOS, GOC:curators, ISBN:0582227089]
synonym: "memory defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000399
name: abnormal courtship behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'" [FBC:DOS, GOC:ai, GOC:dph]
synonym: "courtship behavior defective" EXACT []
is_a: FBcv:0000721 ! abnormal mating behavior

[Term]
id: FBcv:0000400
name: abnormal mating
namespace: phenotypic_class
def: "Phenotype that is any abnormality in mating (GO:0007618). 'mating' is defined as: 'The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.'" [FBC:DOS, GOC:jl, ISBN:0387520546]
subset: fbcvsubset_mgiribbons
synonym: "mating defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000401
name: abnormal mating rhythm
namespace: phenotypic_class
def: "Phenotype that is any abnormality in circadian mating behavior (GO:0035648). 'circadian mating behavior' is defined as: 'The fluctuation in mating behavior that occurs over an approximately 24 hour cycle.'" [FBC:DOS, GOC:bf, GOC:dos, PMID:11470898, PMID:17276917]
synonym: "mating rhythm defective" EXACT []
is_a: FBcv:0000679 ! abnormal circadian behavior
is_a: FBcv:0000721 ! abnormal mating behavior

[Term]
id: FBcv:0000402
name: abnormal song
namespace: phenotypic_class
def: "Phenotype that is any abnormality in male courtship behavior, veined wing generated song production (GO:0045433). This is defined as 'The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.'" [FBC:DOS, GOC:mtg_sensu, PMID:11092827]
synonym: "singing defective" EXACT [FBC:SM]
synonym: "song defective" EXACT []
synonym: "song production defective" EXACT [FBC:SM]
is_a: FBcv:0000399 ! abnormal courtship behavior

[Term]
id: FBcv:0000403
name: abnormal chemosensory behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'." [FBC:DOS, GOC:go_curators]
synonym: "abnormal chemosensitive behavior" EXACT []
synonym: "chemosensitive behavior defective" EXACT []
synonym: "chemosensitive behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000404
name: abnormal smell perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of smell (GO:0007608). 'sensory perception of smell' is defined as: 'The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.'" [FBC:DOS, GOC:ai]
synonym: "olfaction defective" EXACT []
synonym: "smell perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0000405
name: abnormal taste perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of taste (GO:0050909). 'sensory perception of taste' is defined as: 'The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.'" [FBC:DOS, GOC:ai]
synonym: "gustation defective" EXACT []
synonym: "taste defective" EXACT []
synonym: "taste perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0000406
name: abnormal tarsal response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in or absense of proboscis extension reflex in response to a sugar stimulus via taste sensilla on the tarsus." [FBC:DOS]
synonym: "tarsal response defective" EXACT []
is_a: FBcv:0000680 ! abnormal proboscis extension reflex

[Term]
id: FBcv:0000407
name: abnormal auditory perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of sound (GO:0007605). 'sensory perception of sound' is defined as: 'The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.'" [FBC:DOS, GOC:ai]
synonym: "auditory perception defective" EXACT []
synonym: "auditory system defective" RELATED []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0000408
name: abnormal stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to stress (GO:0006950). 'response to stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).'" [FBC:DOS, GOC:mah]
subset: fbcvsubset_mgiribbons
synonym: "environmental stress response defective" NARROW []
synonym: "stress response defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000409
name: abnormal osmotic stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to osmotic stress (GO:0006970). 'response to osmotic stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.'" [FBC:DOS, GOC:jl]
synonym: "osmotic stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000410
name: abnormal heat stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to heat (GO:0009408). 'response to heat' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.'" [FBC:DOS, GOC:lr]
synonym: "heat stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response
is_a: FBcv:0000683 ! abnormal temperature response

[Term]
id: FBcv:0000411
name: abnormal visual behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in visual behavior (GO:0007632). 'visual behavior' is defined as: 'The behavior of an organism in response to a visual stimulus.'" [FBC:DOS, GOC:jid, GOC:pr]
synonym: "visual behavior defective" EXACT []
synonym: "visual behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000412
name: abnormal optomotor response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in optomotor response: a motor response during flight or walking that serves to stabilize both image formation on the retina and locomotor course." [FBC:DOS]
synonym: "optomotor behaviour defective" EXACT []
synonym: "optomotor response defective" EXACT []
is_a: FBcv:0000411 ! abnormal visual behavior

[Term]
id: FBcv:0000413
name: abnormal phototaxis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.'" [FBC:DOS, GOC:jl, ISBN:0192800981]
subset: fbcvsubset_mgiribbons
synonym: "phototaxis behaviour defective" RELATED []
synonym: "phototaxis defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000414
name: abnormal locomotor behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'" [FBC:DOS, GOC:dph]
synonym: "locomotor behavior defective" EXACT []
synonym: "locomotor behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000415
name: abnormal jumping
namespace: phenotypic_class
def: "Phenotype that is a reduced ability to jump or a reduced jump response. This may be due to neurological or muscular defects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "jumping defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000416
name: uncoordinated
namespace: phenotypic_class
def: "Phenotype that is abnormal co-ordination of motor activity." [FBC:CP, FBC:DOS]
is_a: FBcv:0000414 ! abnormal locomotor behavior

[Term]
id: FBcv:0000417
name: abnormal flight
namespace: phenotypic_class
def: "Phenotype that is any abnormality in flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.'" [FBC:DOS, GOC:dph]
comment: This term is agnostic as to the causes of defects in flight. An animal's flight may be defective for mechanical, behavioral or sensory reasons.
subset: fbcvsubset_mgiribbons
synonym: "flight behaviour defective" NARROW []
synonym: "flight defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000418
name: flightless
namespace: phenotypic_class
def: "Phenotype that is the absence of flight (GO:0060361). 'flight' is defined as: 'Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.'" [FBC:DOS, GOC:dph]
comment: This term is agnostic as to the causes of flightlessness. An animal may be flightless for mechanical or behavioral reasons.
is_a: FBcv:0000417 ! abnormal flight

[Term]
id: FBcv:0000419
name: abnormal feeding behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in feeding behavior (GO:0007631). 'feeding behavior' is defined as: 'Behavior associated with the intake of food.'" [FBC:DOS, GOC:mah]
synonym: "feeding behavior defective" EXACT []
synonym: "feeding behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000420
name: abnormal grooming behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'" [FBC:DOS, GOC:jl, GOC:pr]
synonym: "grooming behavior defective" EXACT []
synonym: "grooming behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000421
name: abnormal touch response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in or loss of a stereotypical behavioral response to touch." [FlyBase:FBrf0073546]
comment: This phenotype is commonly assayed by scoring larval avoidance responses following stroking of the thoracic segments (see Kernan et al., 1994). On its own, this is not sufficient evidence for an abnormality in sensory perception of touch, as motor defects can also cause this phenotype.
synonym: "touch response defective" EXACT []
synonym: "touch sensitivity defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000422
name: photoperiod response variant
namespace: phenotypic_class
def: "Phenotype that is any abnormality in entrainment of circadian clock by photoperiod (GO:0043153), which is defined as: 'The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).'" [FBC:DOS, GOC:jl]
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000423
name: abnormal DNA repair
namespace: phenotypic_class
def: "Phenotype that is any abnormality in DNA repair (GO:0006281). 'DNA repair' is defined as: 'The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.'" [FBC:DOS, PMID:11563486]
synonym: "DNA repair defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000424
name: abnormal cell death
namespace: phenotypic_class
def: "Phenotype that is a change in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type. This may be due to effects on the regulation of cell death (GO:0010941) or in cell death (GO:0008219) pathways themselves." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "apoptosis defective" NARROW []
synonym: "cell death defective" EXACT []
synonym: "pcd defective" NARROW []
synonym: "programmed cell death defective" NARROW []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000425
name: increased cell death
namespace: phenotypic_class
def: "Phenotype that is an increase in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
synonym: "pcd increase" NARROW []
synonym: "programmed cell death increase" NARROW []
is_a: FBcv:0000424 ! abnormal cell death

[Term]
id: FBcv:0000426
name: decreased cell death
namespace: phenotypic_class
def: "Phenotype that is a decrease in the amount of cell death in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
synonym: "pcd decrease" NARROW []
synonym: "programmed cell death decrease" NARROW []
synonym: "reduced cell death" EXACT []
is_a: FBcv:0000424 ! abnormal cell death

[Term]
id: FBcv:0000427
name: abnormal cell growth
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell growth (GO:0016049). 'cell growth' is defined as: 'The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.'" [FBC:DOS, GOC:ai]
comment: Note that defects in cell size are not necessarily the result of defects in cell growth. A change in the rate of cell division in the absence of any change in cell growth rate can result in smaller or larger cells.
subset: fbcvsubset_mgiribbons
synonym: "cell growth defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000428
name: abnormal cell size
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the size of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell size defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000429
name: abnormal cell shape
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the shape (PATO:0000052) of some cell compared to wild-type." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell shape defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000430
name: abnormal cell polarity
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the asymmetric distribution of components within a cell. For example an epithelial cell is 'cell polarity defective' if it lacks the normal asymmetric distribution of proteins or cell components such as junctions or villi along its apical-basal axis." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell polarity defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000431
name: abnormal meiotic cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in meiotic cell cycle (GO:0051321). 'meiotic cell cycle' is defined as: 'Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.'" [FBC:DOS, GOC:ai]
synonym: "meiotic" RELATED []
synonym: "meiotic cell cycle defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle

[Term]
id: FBcv:0000432
name: abnormal mitotic cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in mitotic cell cycle (GO:0000278). 'mitotic cell cycle' is defined as: 'Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.'" [FBC:DOS, GOC:mah, ISBN:0815316194]
synonym: "mitotic" RELATED []
synonym: "mitotic cell cycle defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle

[Term]
id: FBcv:0000433
name: abnormal cytokinesis
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cytokinesis (GO:0000910). 'cytokinesis' is defined as: 'The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.'" [FBC:DOS, GOC:mtg_cell_cycle]
synonym: "cytokinesis defective" EXACT []
is_a: FBcv:0000671 ! abnormal cell cycle

[Term]
id: FBcv:0000434
name: abnormal neurophysiology
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the electrophysiological properties of some class of neurons, muscles or other anatomical structure of the nervous system. Examples of these phenotypes at the neuron class level include defects in spontaneous or evoked excitatory junction potential. Examples at a more gross anatomical level include abnormal retinal electrophysiology (e.g.- measured by an electroretinogram)." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "neurophysiology defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000435
name: abnormal neuroanatomy
namespace: phenotypic_class
def: "Phenotype that is any abnormality in the anatomy of the nervous system (FBbt:00005093). 'nervous system' is defined as: 'All the nerve centers and nerve fibers in the central, visceral and peripheral nervous systems.'" [FBC:DOS, FlyBase:FBrf0166419]
subset: fbcvsubset_mgiribbons
synonym: "neuroanatomy defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000436
name: abnormal sex-determination
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sex determination (GO:0007530). 'sex determination' is defined as: 'Any process that establishes and transmits the specification of sexual status of an individual organism.'" [FBC:DOS, ISBN:0198506732]
subset: fbcvsubset_mgiribbons
synonym: "sex-determination defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000437
name: obsolete dosage compensation defective
namespace: phenotypic_class
comment: This term was obsoleted because it was felt that the evidence provided in papers is not enough to annotate with this term. mc161014
is_obsolete: true
consider: FBcv:0000436

[Term]
id: FBcv:0000438
name: electrophoretic variant
namespace: phenotypic_class
def: "Phenotype that is a difference in electrophoretic migration of a gene product compared to wild-type." [FBC:DOS]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000439
name: chemical resistant
namespace: phenotypic_class
def: "Phenotype that is a decreased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000440
name: chemical sensitive
namespace: phenotypic_class
def: "Phenotype that is an increased sensitivity (compared to wild-type) to the toxic effects of some specified chemical. The phrase 'toxic effects' here refers to reversible effects such as inebriation and sedation as well as sustained damage, developmental defects and death." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000441
name: radiation resistant
namespace: phenotypic_class
def: "Phenotype that is a decreased tendency for radiation exposure to cause toxic effects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000442
name: radiation sensitive
namespace: phenotypic_class
def: "Phenotype that is an increased tendency for radiation exposure to cause toxic effects." [FBC:DOS]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000443
name: Minute
namespace: phenotypic_class
def: "Dominant phenotype consisting of short slender bristles and delayed development. Homozygotes are cell lethal." [FlyBase:FBrf0066905]
comment: The phenotype may be a general result of mutations in essential components of the protein synthesis pathway, as a number of Minutes encode ribosomal proteins. In an animal that is heterozygous for a Minute mutation, cells with two wild-type alleles of the affected gene have a growth advantage. Many developmental studies take advantage of this fact to give somatic clones a growth advantage. The term 'Minute' should not be used to annotate the resulting phenotypes.
is_a: FBcv:0000450 ! abnormal developmental rate

[Term]
id: FBcv:0000444
name: hyperplasia
namespace: phenotypic_class
def: "Phenotype that is an increase in the number of cells in a tissue or organ, usually associated with an increase in size, where the affected tissue or organ maintains its normal form." [ISBN:978-0-19-850673-7]
synonym: "hyperplastic" EXACT []
is_a: FBcv:0000362 ! increased cell number

[Term]
id: FBcv:0000445
name: obsolete tumorigenic
namespace: phenotypic_class
def: "Phenotype that is characterized by the formation of abnormal masses of tissue (tumors) as the result of neoplasia." [FBC:DOS]
comment: Obsoleted as this is the same phenotype as neoplasia.
is_obsolete: true
replaced_by: FBcv:0000723

[Term]
id: FBcv:0000446
name: melanotic mass phenotype
namespace: phenotypic_class
def: "Phenotype characterized by the formation of lumps of melanotic tissue inside the body in the absence of foreign bodies." [FlyBase:FBrf0094387, FlyBase:FBrf0194475]
comment: Melanotic capsules are formed around foreign bodies in wild-type animals as part of the immune response, for example as a protection against parasitoid wasps. Some, but not all melanotic mass phenotypes involve ectopic activation of this immune response. While melanotic masses are commonly referred to as melanotic tumors in the historical literature, this is a misnomer as they are rarely neoplastic.
synonym: "melanotic 'tumor'" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000447
name: melanotic necrosis
namespace: phenotypic_class
def: "Phenotype characterized by closely associated necrosis and melanization." [FlyBase:FBrf0155704]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000448
name: abnormal immune response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in immune response (GO:0006955). 'immune response' is defined as: 'Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.'" [FBC:DOS, GO_REF:0000022, GOC:add]
subset: fbcvsubset_mgiribbons
synonym: "immune response defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000449
name: abnormal planar polarity
namespace: phenotypic_class
def: "Phenotype that is any abnormality in establishment of planar polarity (GO:0001736). 'establishment of planar polarity' is defined as: 'Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.'" [GOC:dph]
comment: For apical-basal polarity phenotypes of epithelia, the appropriate term is 'cell polarity defective'.
subset: fbcvsubset_mgiribbons
synonym: "planar polarity defective" EXACT []
synonym: "tissue polarity defective" BROAD []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000450
name: abnormal developmental rate
namespace: phenotypic_class
def: "Phenotype that is a change in any kind of rate (e.g. speed, frequency) of any developmental process (GO:0032502) taking place prior to mature adulthood (defined as adult stage A3), compared to wild-type. Note, developmental processes include stages in development of the whole animal (e.g. larval development) as well as specific sub-processes, such as dorsal closure." [FBC:DOS]
comment: A more complete formalization would require a clause specifying stage. It might be possible to do this in OWL using the same system as we are using for lethal phase.
subset: fbcvsubset_mgiribbons
synonym: "developmental rate defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000451
name: abnormal wound healing
namespace: phenotypic_class
def: "Phenotype that is any abnormality in wound healing (GO:0042060). 'wound healing' is defined as: 'The series of events that restore integrity to a damaged tissue, following an injury.'" [GOC:bf, PMID:15269788]
synonym: "wound healing defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000452
name: origin of mutation
namespace: origin_of_mutation
def: "Describes the origin of the mutation that causes a phenotype." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000807 ! allele descriptor

[Term]
id: FBcv:0000453
name: obsolete piggyBac ammunition for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000454
name: obsolete synthetic
namespace: origin_of_mutation
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000455
name: in vitro construct
namespace: origin_of_mutation
def: "DNA change introduced by using an in vitro construct. The sequence of the in vitro construct determines the type of change." [FBC:MMC]
synonym: "change induced by in vitro construct" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000456
name: obsolete in vitro construct - regulatory fusion
namespace: origin_of_mutation
def: "Sequence change introduced by using an in vitro construct that contains a fusion of the regulatory region of one gene on to the coding region of another. Examples in FlyBase include heat shock constructs, FRT flip out constructs and reporter genes." [FBC:DOS]
comment: This term has been obsoleted because the nature of an in vitro construct (e.g. 'regulatory fusion') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information.
synonym: "change induced by an in vitro construct - regulatory fusion" EXACT []
synonym: "in vitro construct | regulatory fusion" RELATED []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000457
name: obsolete in vitro construct - coding region fusion
namespace: origin_of_mutation
def: "Sequence change introduced by using an in vitro construct that contains a in-frame fusion of the open reading frames from two or more genes. In FlyBase, the resulting genes may be classified as fusion genes or tagged genes." [FBC:DOS]
comment: This term has been obsoleted because the nature of an in vitro construct (e.g. 'coding region fusion') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information.
synonym: "change induced by an in vitro construct - coding region fusion" EXACT []
synonym: "in vitro construct | coding region fusion" RELATED []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000458
name: obsolete in vitro construct - site directed mutagenesis
namespace: origin_of_mutation
def: "Mutation induced by an in vitro construct that uses site directed mutagenesis to target a particular region of the gene." [FBC:DOS]
comment: This term has been obsoleted because the nature of an in vitro construct (e.g. 'site directed mutagenesis') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information.
synonym: "in vitro construct | site directed mutagenesis" RELATED []
synonym: "mutation induced by an in vitro construct - site directed mutagenesis" EXACT []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000459
name: obsolete in vitro construct - deletion
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct generated by internal deletion of some genomic sequence or cDNA." [FBC:DOS]
comment: This term has been obsoleted because the nature of an in vitro construct (e.g. 'deletion') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information.
synonym: "change induced by an in vitro construct - deletion" EXACT []
synonym: "in vitro construct | deletion" RELATED []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000460
name: obsolete in vitro construct - genomic fragment
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct containing a genomic fragment that partially or fully rescues loss of function mutations or deletions of the gene whose sequence it carries." [FBC:DOS]
comment: This term has been obsoleted because the nature of an in vitro construct (e.g. 'genomic fragment') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information.
synonym: "change induced by an in vitro construct - genomic fragment" EXACT []
synonym: "in vitro construct | genomic fragment" RELATED []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000461
name: obsolete in vitro construct - minigene
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct that contains the wild-type open reading frame of a gene (without introns), the expression of which is controlled by a wild-type promoter of the same gene. Such constructs are often generated by fusing a cDNA to a genomic region containing promoter sequences, or more rarely by deletion of introns and other non-essential sequences from a genomic region, leaving a wild type coding region and promoter intact." [FBC:DOS]
comment: This term has been obsoleted because the nature of an in vitro construct (e.g. 'minigene') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information.
synonym: "change induced by an in vitro construct - minigene" EXACT []
synonym: "in vitro construct | minigene" RELATED []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000462
name: obsolete in vitro construct - amino acid replacement
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct that uses site directed mutagenesis to target a particular region of the gene resulting in a change to the change to the amino acids sequence encodes.." [FBC:DOS]
comment: This term has been obsoleted because the nature of an in vitro construct (e.g. 'amino acid replacement') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information.
synonym: "change induced by an in vitro construct - amino acid replacement" EXACT []
synonym: "in vitro construct | amino acid replacement" RELATED []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000463
name: obsolete in vitro construct - RNAi
namespace: origin_of_mutation
def: "Sequence change introduced by an in vitro construct designed to generate dsRNA for RNA interference (RNAi) experiments." [FBC:DOS]
comment: This term has been obsoleted because the nature of an in vitro construct (e.g. 'RNAi') is now captured in FlyBase using SO terms instead and the parent term (in vitro construct) is used to capture the origin_of_mutation information.
synonym: "change induced by an in vitro construct - RNAi" EXACT []
synonym: "in vitro construct | RNAi" RELATED []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000464
name: obsolete in vitro construct - other
namespace: origin_of_mutation
synonym: "in vitro construct | other" EXACT []
is_obsolete: true
consider: FBcv:0000455

[Term]
id: FBcv:0000465
name: natural population
namespace: origin_of_mutation
def: "Mutation found in a natural population." [FBC:MMC]
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000466
name: temperature
namespace: origin_of_mutation
def: "Mutation caused by exposure to a temperature that is higher or lower than 25 degrees Celsius." [FBC:MMC]
synonym: "environmental treatment" RELATED []
synonym: "mutation induced by temperature treatment" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000467
name: cold
namespace: origin_of_mutation
def: "Mutation induced by exposure to temperature that is lower than 25 degrees Celsius." [FBC:MMC]
synonym: "cold-treatment" RELATED []
synonym: "mutation induced by cold treatment" EXACT []
is_a: FBcv:0000466 ! temperature

[Term]
id: FBcv:0000468
name: heat
namespace: origin_of_mutation
def: "Mutation induced by exposure to a temperature that is higher than 25 degrees Celsius." [FBC:MMC]
synonym: "heat-treatment" RELATED []
synonym: "mutation induced by heat treatment" EXACT []
is_a: FBcv:0000466 ! temperature

[Term]
id: FBcv:0000469
name: spontaneous
namespace: origin_of_mutation
def: "Mutation caused by a spontaneous event." [FBC:MMC]
synonym: "mutation induced by spontaneous event" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000470
name: recombination
namespace: origin_of_mutation
def: "Sequence change induced by the genetic exchange that takes place between DNA sequences." [FBC:MC, ISBN:978-0-8153-3218-3]
synonym: "change induced by recombination" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000471
name: gene conversion
namespace: origin_of_mutation
def: "Sequence change caused by a DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor (GO:0035822)." [PMID:17846636]
comment: Strictly, gene conversion (GO:0035822) defines only the endogenous process, not its use for engineered gene targeting.
synonym: "change induced by gene conversion" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000472
name: intralocus exchange
namespace: origin_of_mutation
def: "Mutation caused by a recombination event that causes the unequal exchange of small intralocus regions, usually leading to the formation of duplication and deficiency products." [FBC:MC, FlyBase:FBrf0014117, FlyBase:FBrf0202435]
synonym: "mutation induced by intralocus exchange" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000473
name: unequal recombination
namespace: origin_of_mutation
def: "Sequence change caused by a recombination event that causes an unequal exchange of genetic material between homologous or non-homologous regions." [FlyBase:FBrf0202435]
synonym: "change induced by unequal recombination" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000474
name: mitotic recombination
namespace: origin_of_mutation
def: "Sequence change caused by the exchange of genetic material during mitosis that occurs at crossing over, and more frequently between homologous chromosomes." [FlyBase:FBrf0202435]
synonym: "change induced by mitotic recombination" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000475
name: magnification
namespace: origin_of_mutation
def: "Sequence change caused by a recombination event between tandem repeats of rRNA genes that causes unequal chromatid exchange at crossing over and an increase in the number of functional copies. It causes a reversion from mutant to wild-type phenotype." [FlyBase:FBrf0202435, FlyBase:FBrf0218934]
synonym: "mutation induced by magnification" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000476
name: detachment
namespace: origin_of_mutation
def: "Mutation that is caused by a recombination event that causes the breakdown of compound chromosome arms resulting in duplications or deletions in proximal regions." [FBC:MC, FlyBase:FBrf0202435]
synonym: "mutation induced by detachment" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000477
name: reduction
namespace: origin_of_mutation
def: "Mutation caused by a recombination event between tandem repeats of rRNA genes that causes unequal chromatid exchange at crossing over and a reduction in the number of functional copies. It leads to an aggravation of phenotype, in the case of a mutation causing a change from a wildtype to mutant phenotype or a change from a mutant to a more severe mutant phenotype." [FlyBase:FBrf0026874]
synonym: "mutation induced by reduction" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000478
name: site specific recombination
namespace: origin_of_mutation
def: "Sequence change induced by a recombination event catalyzed by a recombinase that occurs at specific nucleotide sequences." [FlyBase:FBrf0202435, ISBN:978-0-8153-3218-3]
synonym: "change induced by site specific recombination" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000479
name: FLPase
namespace: origin_of_mutation
def: "Sequence change caused by a site specific recombination event catalyzed by the tyrosine recombinase FLPase, that recognizes minimal FLP recombination target (FRT) sites of 34 base pairs. For site specific integration, the recombination site consists of 48 base pairs containing an additional isolated base pair and a third 13 base pair direct repeat." [FlyBase:FBrf0201927, UniProt:P03870]
synonym: "change induced by FLPase recombination" EXACT []
is_a: FBcv:0000478 ! site specific recombination

[Term]
id: FBcv:0000480
name: I-SceI
namespace: origin_of_mutation
def: "Sequence change caused by the cleavage of an 18 base pair DNA sequence by the I-SceI endonuclease." [FlyBase:FBrf0128625, UniProt:P03882]
synonym: "change induced by I-SceI endonuclease cleavage" EXACT []
synonym: "SCEI endonuclease" RELATED []
is_a: FBcv:0003007 ! site specific cleavage

[Term]
id: FBcv:0000481
name: cre recombinase
namespace: origin_of_mutation
def: "Sequence change induced by a site specific recombination event catalyzed by the tyrosine recombinase cre. Recombination is induced between two 34 base pairs loxP sites. These consist of two 13 base pair perfect inverted repeats flanking an 8 base pair asymmetric spacer that confers directionality." [FlyBase:FBrf0201927, PMID:6954485, UniProt:P06956]
synonym: "change induced by cre recombinase recombination" EXACT []
synonym: "Cre recombinase" RELATED []
is_a: FBcv:0000478 ! site specific recombination

[Term]
id: FBcv:0000482
name: segregation
namespace: origin_of_mutation
def: "Sequence change induced by chromosomal segregation." [FBC:MMC]
synonym: "change induced by segregation" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000483
name: transposable element activity
namespace: origin_of_mutation
def: "Mutation induced by the mobilization of a transposable element." [FBC:MC, FlyBase:FBrf0202435]
synonym: "mutation induced by transposable element activity" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000484
name: IR-hybrid dysgenesis
namespace: origin_of_mutation
def: "Mutation caused by hybrid dysgenesis that results from the mobilization of the I-element retrotransposon." [FlyBase:FBrf0202435]
synonym: "IR" RELATED []
synonym: "mutation induced by IR-hybrid dysgenesis" EXACT []
is_a: FBcv:0003019 ! I-element activity

[Term]
id: FBcv:0000485
name: Stalker-hybrid dysgenesis
namespace: origin_of_mutation
def: "Mutation induced by hybrid dysgenesis caused by the mobilization of the Stalker transposable element." [FlyBase:FBrf0202435]
synonym: "mutation induced by Stalker-hybrid dysgenesis" EXACT []
is_a: FBcv:0003020 ! Stalker element activity

[Term]
id: FBcv:0000486
name: P-element activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by a P-element, a DNA transposable element. The P-element is 2.9 kilobases in length with 31 base pairs inverted terminal repeats. Upon insertion it generates a flanking duplication of 8 base pairs at the target site upon insertion. Mobilization is induced by the activity of a P-element transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by P-element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000487
name: PM hybrid dysgenesis
namespace: origin_of_mutation
def: "Mutation caused by hybrid dysgenesis that results from the action of the P-element." [FlyBase:FBrf0202435]
synonym: "mutation induced by PM hybrid dysgenesis" EXACT []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000488
name: Delta2-3 transposase
namespace: origin_of_mutation
def: "Mutation induced by the mobilization of a P-element by the Delta2-3 transposase. The source of Delta2-3 is a stable genomic integration from which the third intron has been deleted." [FlyBase:FBrf0202435]
synonym: "mutation induced by P-element mobilization by Delta2-3 transposase" EXACT []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000489
name: jumpstarter activity
namespace: origin_of_mutation
def: "Mutation caused by a P-element that is inserted into the genome and that is used to create more insertions at other sites." [FlyBase:FBrf0202435]
synonym: "Js" RELATED []
synonym: "Jumpstarter" RELATED []
synonym: "mutation induced by jumpstarter mobilization" EXACT []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000490
name: p pi25.1 supplied transposase
namespace: origin_of_mutation
def: "Mutation caused by the mobilization of a P-element by the transposase produced from the helper plasmid p pi25.1. This plasmid is a P-element from which the 3' terminus has been deleted, making it unable to integrate into the host's DNA. It is missing a 23 base pairs deletion of the 3' terminus compared to p pi25.1wc." [FlyBase:FBrf0202435]
synonym: "mutation induced by P-element mobilization by p pi25.1 supplied transposase" EXACT []
synonym: "p pi25.1" RELATED []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000491
name: p pi25.7wc
namespace: origin_of_mutation
def: "Mutation caused by the mobilization of a P-element by the transposase produced from the helper plasmid p pi25.7wc. This plasmid is a P-element from which the 3' terminus has been deleted, making it unable to integrate into the host's DNA. It has an additional 23 base pairs deletion of the 3' terminus compared to p pi25.1." [FlyBase:FBrf0202435]
synonym: "mutation induced by P-element mobilization by p pi25.7wc supplied transposase" EXACT []
synonym: "p pi25.7wc" RELATED []
is_a: FBcv:0000486 ! P-element activity

[Term]
id: FBcv:0000492
name: male recombination induced by dysgenesis
namespace: origin_of_mutation
def: "Mutation caused by PM hybrid dysgenesis that is induced by the higher frequency of recombination in certain male chromosomes." [FlyBase:FBrf0202435]
synonym: "MR" RELATED []
synonym: "mutation induced by male recombination" EXACT []
is_a: FBcv:0000487 ! PM hybrid dysgenesis

[Term]
id: FBcv:0000493
name: MRh12 induced male recombination
namespace: origin_of_mutation
def: "Mutation caused by a male recombination event induced by a male recombination factor which is present in chromosomes extracted from a population in Haifa, Israel." [FlyBase:FBrf0202435]
synonym: "MRh12" RELATED []
synonym: "mutation induced by MRh12 male recombination" EXACT []
is_a: FBcv:0000492 ! male recombination induced by dysgenesis

[Term]
id: FBcv:0000494
name: MRT007 induced male recombination
namespace: origin_of_mutation
def: "Mutation caused by a male recombination event in the second and third chromosomes induced by a male recombination factor which is present in chromosomes extracted from a population in Harlingen, Texas." [FlyBase:FBrf0202435]
synonym: "MRT007" RELATED []
synonym: "mutation induced by MRT007 male recombination" EXACT []
is_a: FBcv:0000492 ! male recombination induced by dysgenesis

[Term]
id: FBcv:0000495
name: MRF23.5 induced male recombination
namespace: origin_of_mutation
def: "Mutation caused by a male recombination event induced by male recombination factor 23.5 MRF which is present in second chromosomes extracted from a population in Patras, Greece." [FlyBase:FBrf0039984, FlyBase:FBrf0202435]
synonym: "23.5 MRF" EXACT [FlyBase:FBrf0039984]
synonym: "MRF23.5" RELATED []
synonym: "mutation induced by MRF23.5 male recombination" EXACT []
is_a: FBcv:0000492 ! male recombination induced by dysgenesis

[Term]
id: FBcv:0000496
name: MRF31.1 induced male recombination
namespace: origin_of_mutation
def: "Mutation caused by a male recombination event induced by male recombination factor 31.1 MRF which is present in second chromosomes extracted from a population in Patras, Greece." [FlyBase:FBrf0030109, FlyBase:FBrf0202435]
synonym: "31.1 MRF" EXACT [FlyBase:FBrf0030109]
synonym: "MRF31.1" RELATED []
synonym: "mutation induced by MRF31.1 male recombination" EXACT []
is_a: FBcv:0000492 ! male recombination induced by dysgenesis

[Term]
id: FBcv:0000497
name: hobo activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by hobo, a DNA transposable element. The hobo element is 3.0 kilobases in length with 12 base pairs inverted terminal repeats. After mobilization by the hobo transposase and upon insertion it generates a flanking duplication of 8 base pairs at the target site upon insertion." [FlyBase:FBrf0202435]
synonym: "mutation induced by hobo element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000498
name: hobo dysgenesis
namespace: origin_of_mutation
def: "Mutation caused by hybrid dysgenesis that results from the mobilization of the hobo element." [FlyBase:FBrf0202435]
synonym: "mutation induced by hobo dysgenesis" EXACT []
is_a: FBcv:0000497 ! hobo activity

[Term]
id: FBcv:0000499
name: HBL1 supplied transposase
namespace: origin_of_mutation
def: "Mutation caused by the activity of the hobo element, mobilized by an hobo transposase which is produced from the supplied P-element helper plasmid HBL1." [FlyBase:FBrf0202435]
synonym: "Hobbled1" RELATED []
synonym: "Hobo transposase source" RELATED []
synonym: "mutation induced by Hobo transposase source HBL1" EXACT []
is_a: FBcv:0000497 ! hobo activity

[Term]
id: FBcv:0000500
name: mariner activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by mariner, a DNA transposable element. The mariner element is 1.3 kilobases in length with 28 base pairs inverted terminal repeats. It specifically targets TA dinucleotides and generates a flanking duplication of these two bases upon insertion. Mobilization is induced by the activity of the mariner transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by mariner activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000501
name: gypsy element activity
namespace: origin_of_mutation
def: "Mutation induced by transposable activity caused by the gypsy retrovirus. The gypsy element is a 7.5 kilobases in length with 482 base pairs terminal repeats. Mobilization is induced by the activity of the gypsy element transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by gypsy element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000502
name: piggyBac activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by piggyBac, a DNA transposable element. The piggyBac is 2.5 kilobases in length with 13 base pairs inverted terminal repeats. It specifically targets TTAA dinucleotides and generates a flanking duplication of these 4 base pairs upon insertion. Mobilization is induced by the activity of the piggyBac transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by piggyBac activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0000503
name: irradiation
namespace: origin_of_mutation
def: "Mutation induced by exposure to radiation." [FBC:MMC]
synonym: "mutation induced by irradiation" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000504
name: ionizing radiation
namespace: origin_of_mutation
def: "Mutation induced by exposure to ionizing radiation." [FBC:MMC]
synonym: "mutation induced by ionizing irradiation" EXACT []
is_a: FBcv:0000503 ! irradiation

[Term]
id: FBcv:0000505
name: alpha ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to alpha rays." [FBC:MMC]
synonym: "mutation induced by alpha ray irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000506
name: gamma ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to gamma rays." [FBC:MMC]
synonym: "mutation induced by gamma ray irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000507
name: 60Co gamma ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to 60Co gamma rays." [FBC:MMC]
synonym: "mutation induced by 60Co gamma ray irradiation" EXACT []
is_a: FBcv:0000506 ! gamma ray

[Term]
id: FBcv:0000508
name: 137Cs gamma ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to 137Cs gamma rays." [FBC:MMC]
synonym: "mutation induced by 137Cs gamma ray irradiation" EXACT []
is_a: FBcv:0000506 ! gamma ray

[Term]
id: FBcv:0000509
name: 226Ra alpha ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to 226Ra alpha rays." [FBC:MMC]
synonym: "mutation induced by 226Ra alpha ray irradiation" EXACT []
synonym: "radium" RELATED []
is_a: FBcv:0000505 ! alpha ray

[Term]
id: FBcv:0000510
name: 32P
namespace: origin_of_mutation
def: "The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days (from CHEBI)." [CHEBI:37972]
synonym: "32-phosphorous" EXACT []
synonym: "mutation induced by 32-P irradiation" EXACT []
synonym: "phosphorus-32 atom" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000511
name: 3H
namespace: origin_of_mutation
def: "The radioactive isotope of hydrogen with relative atomic mass 3.016049 and half-life of 12.33 years (from Greek taurhoiotatauomicronsigma, third) (from CHEBI)." [CHEBI:29238]
synonym: "hydrogen-3" EXACT []
synonym: "mutation induced by 3H irradiation" EXACT []
synonym: "tritium atom" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000512
name: 3H-deoxycytidine
namespace: origin_of_mutation
def: "Mutation induced by exposure to 3H-deoxycytidine radiation." [FBC:MMC]
synonym: "mutation induced by 3H-deoxycytidine irradiation" EXACT []
synonym: "tritiated 2'-deoxycytidine" EXACT []
synonym: "tritiated deoxycytidine" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000513
name: 3H-thymidine
namespace: origin_of_mutation
def: "Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis (from CHEBI)." [CHEBI:53526]
synonym: "mutation induced by 3H-thymidine irradiation" EXACT []
synonym: "tritiated thymidine" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000514
name: Bevatron
namespace: origin_of_mutation
def: "Mutation induced by treatment in a Bevatron." [FBC:MMC]
synonym: "mutation induced by Bevatron irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000515
name: deuteron
namespace: origin_of_mutation
def: "Mutation induced by exposure to deuteron radiation." [FBC:MMC]
synonym: "mutation induced by deuteron irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000516
name: neutron
namespace: origin_of_mutation
def: "Mutation induced by exposure to neutron radiation." [FBC:MMC]
synonym: "mutation induced by neutron irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000517
name: 252Cf fission neutron
namespace: origin_of_mutation
def: "Mutation induced by exposure to 252Cf fission neutron radiation." [FBC:MMC]
synonym: "mutation induced by 252Cf fission neutron irradiation" EXACT []
is_a: FBcv:0000516 ! neutron

[Term]
id: FBcv:0000518
name: X ray
namespace: origin_of_mutation
def: "Mutation induced by exposure to X rays." [FBC:MMC]
synonym: "mutation induced by X ray irradiation" EXACT []
is_a: FBcv:0000504 ! ionizing radiation

[Term]
id: FBcv:0000519
name: non-ionizing radiation
namespace: origin_of_mutation
def: "Mutation induced by exposure to non-ionizing radiation." [FBC:MMC]
synonym: "mutation induced by non-ionizing irradiation" EXACT []
is_a: FBcv:0000503 ! irradiation

[Term]
id: FBcv:0000520
name: magnetic field
namespace: origin_of_mutation
def: "Mutation induced by exposure to a magnetic field." [FBC:MMC]
synonym: "mutation induced by magnetic field irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000521
name: radio waves
namespace: origin_of_mutation
def: "Mutation induced by exposure to radio waves." [FBC:MMC]
synonym: "mutation induced by radio waves irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000522
name: stratosphere
namespace: origin_of_mutation
def: "Mutation induced by exposure to the stratosphere." [FBC:MMC]
synonym: "mutation induced by stratosphere irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000523
name: supersonic
namespace: origin_of_mutation
def: "Mutation induced by exposure to supersonic radiation." [FBC:MMC]
synonym: "mutation induced by supersonic irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000524
name: U.V.
namespace: origin_of_mutation
def: "Mutation induced by exposure to U.V. radiation." [FBC:MMC]
synonym: "mutation induced by U.V. irradiation" EXACT []
is_a: FBcv:0000519 ! non-ionizing radiation

[Term]
id: FBcv:0000525
name: chemical
namespace: origin_of_mutation
def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances (from CHEBI)." [CHEBI:24431]
synonym: "mutation induced by chemical exposure" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0000526
name: alkylating agent
namespace: origin_of_mutation
def: "Any chemical (FBcv:0000525) that has role some alkylating agent (CHEBI:22333)." [CHEBI:22333]
synonym: "mutation induced by alkylating agent exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000527
name: diethyl sulfate
namespace: origin_of_mutation
def: "The diethyl ester of sulfuric acid (from CHEBI)." [CHEBI:34699]
synonym: "DES" RELATED []
synonym: "mutation induced by diethyl sulfate exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000528
name: 2-chloroethyl methanesulfonate
namespace: origin_of_mutation
def: "No definition for CHEBI:19508." [CHEBI:19508]
synonym: "CB1506" RELATED []
synonym: "mutation induced by 2-chloroethyl methanesulfonate exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000529
name: 2-fluoroethyl methanesulfonate
namespace: origin_of_mutation
def: "No definition for CHEBI:19579." [CHEBI:19579]
synonym: "CB1522" RELATED []
synonym: "mutation induced by 2-fluoroethyl methanesulfonate exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000530
name: ethyl methanesulfonate
namespace: origin_of_mutation
def: "A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol (from CHEBI)." [CHEBI:23994]
synonym: "CB1528" RELATED []
synonym: "EMS" RELATED []
synonym: "mutation induced by EMS exposure" EXACT []
synonym: "mutation induced by ethyl methanesulfonate exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000531
name: ethyl nitrosourea
namespace: origin_of_mutation
def: "A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups (from CHEBI)." [CHEBI:23995]
synonym: "ENU" RELATED []
synonym: "mutation induced by ENU exposure" EXACT []
synonym: "mutation induced by ethyl nitrosourea exposure" EXACT []
synonym: "N-ethyl-N-nitrosourea" RELATED [CHEBI:23995]
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000532
name: hycanthon methanesulfonate
namespace: origin_of_mutation
def: "A methanesulfonate salt resulting from the reaction of equimolar amounts of hycanthone and methanesulfonic acid. It was formerly used as a schistosomicide for individual or mass treatement of infection with Schistosoma haematobium and S. mansoni, but due to its toxicity and concern about possible carcinogenicity, it has been replaced by other drugs such as praziquantel (from CHEBI)." [CHEBI:24624]
synonym: "HMS" RELATED []
synonym: "hycanthone mesylate" RELATED [CHEBI:24624]
synonym: "mutation induced by HMS exposure" EXACT []
synonym: "mutation induced by hycanthon methanesulfonate exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000533
name: methyl methanesulfonate
namespace: origin_of_mutation
def: "A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol (from CHEBI)." [CHEBI:25255]
synonym: "CB1540" RELATED []
synonym: "MMS" RELATED []
synonym: "mutation induced by methyl methanesulfonate exposure" EXACT []
synonym: "mutation induced by MMS exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000534
name: bis(2-chloroethyl) sulfide
namespace: origin_of_mutation
alt_id: FBcv:0000536
def: "An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention (from CHEBI)." [CHEBI:25434]
synonym: "1,1'-thiobis(2-chloroethane)" RELATED [CHEBI:25434]
synonym: "CB1735" RELATED []
synonym: "mustard gas" RELATED [CHEBI:25434]
synonym: "mutation induced by bis(2-chloroethyl) sulfide exposure" EXACT []
synonym: "mutation induced by mustard gas exposure" EXACT []
synonym: "mutation induced by sulfur gas exposure" EXACT []
synonym: "sulfur mustard" RELATED [CHEBI:25434]
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000535
name: N-methyl-N'-nitro-N-nitrosoguanidine
namespace: origin_of_mutation
def: "An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position (from CHEBI)." [CHEBI:21759]
synonym: "MNNG" RELATED []
synonym: "mutation induced by N-methyl-N'-nitro-N-nitrosoguanidine exposure" EXACT []
synonym: "NNG" RELATED []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000537
name: obsolete minos ammunition for transposable element mutagenesis
is_obsolete: true

[Term]
id: FBcv:0000538
name: carbamate
namespace: origin_of_mutation
def: "No definition for CHEBI:13941." [CHEBI:13941]
synonym: "mutation induced by carbamate exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000539
name: urethane
namespace: origin_of_mutation
def: "A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages (from CHEBI)." [CHEBI:17967]
synonym: "mutation induced by urethane exposure" EXACT []
is_a: FBcv:0000538 ! carbamate

[Term]
id: FBcv:0000540
name: vinyl carbamate
namespace: origin_of_mutation
def: "No definition for CHEBI:27292." [CHEBI:27292]
synonym: "mutation induced by vinyl carbamate exposure" EXACT []
is_a: FBcv:0000538 ! carbamate

[Term]
id: FBcv:0000541
name: intercalating agent
namespace: origin_of_mutation
def: "Any chemical (FBcv:0000525) that has role some intercalator (CHEBI:24853)." [CHEBI:24853]
synonym: "mutation induced by intercalating agent exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000542
name: mitomycin C
namespace: origin_of_mutation
def: "No definition for CHEBI:27504." [CHEBI:27504]
synonym: "mutation induced by mitomycin C exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000543
name: quinacrine mustard
namespace: origin_of_mutation
def: "No definition for CHEBI:37595." [CHEBI:37595]
comment: Mapped to CHEBI on basis of synonym - quinacrine mustard. Originally primary name, ICR 100 is now relegated to a synonym.
synonym: "2-methoxy-6-[3-(ethyl-2-chloroethyl)aminopropylamino]acridine" RELATED []
synonym: "ICR 100" RELATED [CHEBI:37595]
synonym: "mutation induced by quinacrine mustard exposure" EXACT []
is_a: FBcv:0000541 ! intercalating agent
is_a: FBcv:0000813 ! nitrogen mustard

[Term]
id: FBcv:0000544
name: ICR 170
namespace: origin_of_mutation
def: "No definition for CHEBI:21183." [CHEBI:21183]
synonym: "2-methoxy-6-dichloro-9-(3-ethyl-2-chloroethyl-aminopropylamino)acridine-dihydrochloride" RELATED []
synonym: "mutation induced by ICR 170 exposure" EXACT []
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000545
name: 1,2-dibromoethane
namespace: origin_of_mutation
def: "A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae (from CHEBI)." [CHEBI:28534]
synonym: "DBE" RELATED []
synonym: "mutation induced by 1,2-dibromoethane exposure" EXACT []
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000546
name: 1,2-dichloroethane
namespace: origin_of_mutation
def: "A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2 (from CHEBI)." [CHEBI:27789]
synonym: "DCE" RELATED []
synonym: "mutation induced by 1,2-dichloroethane exposure" EXACT []
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000547
name: 1-bromo-2-chloroethane
namespace: origin_of_mutation
def: "A haloalkane that is bromoethane substituted by chlorine at position 2 (from CHEBI)." [CHEBI:19032]
synonym: "BCE" RELATED []
synonym: "mutation induced by 1-bromo-2-chloroethane exposure" EXACT []
is_a: FBcv:0000541 ! intercalating agent

[Term]
id: FBcv:0000548
name: base analog
namespace: origin_of_mutation
def: "A molecule that can substitute for a normal nucleobase in nucleic acids (from CHEBI)." [CHEBI:67142]
synonym: "nucleobase analogue" RELATED [CHEBI:67142]
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000549
name: 5-bromouracil
namespace: origin_of_mutation
def: "A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen (from CHEBI)." [CHEBI:20552]
synonym: "mutation induced by 5-bromouracil exposure" EXACT []
is_a: FBcv:0000548 ! base analog

[Term]
id: FBcv:0000550
name: 5-bromouridine
namespace: origin_of_mutation
def: "A uridine having a bromo substituent at the 5-position (from CHEBI)." [CHEBI:20553]
synonym: "mutation induced by 5-bromouridine exposure" EXACT []
is_a: FBcv:0000548 ! base analog

[Term]
id: FBcv:0000551
name: enzyme inhibitor
namespace: origin_of_mutation
def: "Any chemical (FBcv:0000525) that has role some enzyme inhibitor (CHEBI:23924)." [CHEBI:23924]
synonym: "mutation induced by enzyme inhibitor exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000552
name: aminopterin
namespace: origin_of_mutation
def: "No definition for CHEBI:22526." [CHEBI:22526]
synonym: "mutation induced by aminopterin exposure" EXACT []
is_a: FBcv:0000551 ! enzyme inhibitor

[Term]
id: FBcv:0000553
name: inorganic compound
namespace: origin_of_mutation
def: "A molecular entity that contains no carbon (from CHEBI)." [CHEBI:24835]
synonym: "inorganic molecular entity" EXACT [CHEBI:24835]
synonym: "mutation induced by inorganic compound exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000554
name: cupric sulfate
namespace: origin_of_mutation
def: "A metal sulfate compound having copper(2+) as the metal ion (from CHEBI)." [CHEBI:23414]
synonym: "copper(2+) sulfate" RELATED [CHEBI:23414]
synonym: "mutation induced by cupric sulfate" EXACT []
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000555
name: H3BO3
namespace: origin_of_mutation
def: "No definition for CHEBI:33118." [CHEBI:33118]
synonym: "mutation induced by H3BO3 exposure" EXACT []
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000556
name: sodium bisulphite
namespace: origin_of_mutation
def: "An inorganic sodium salt having hydrogensulfite as the counterion (from CHEBI)." [CHEBI:26709]
synonym: "mutation induced by sodium bisulphite exposure" EXACT []
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000557
name: sodium fluoride
namespace: origin_of_mutation
def: "A metal fluoride salt with a Na(+) counterion (from CHEBI)." [CHEBI:28741]
synonym: "mutation induced by sodium fluoride exposure" EXACT []
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000558
name: epoxy hydrocarbon
namespace: origin_of_mutation
def: "Mutation induced by exposure to epoxy hydrocarbon." [FBC:MMC]
synonym: "mutation induced by epoxy hydrocarbon exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000559
name: diepoxybutane
namespace: origin_of_mutation
def: "No definition for CHEBI:23704." [CHEBI:23704]
synonym: "DEB" RELATED []
synonym: "erythritol anhydride" RELATED []
synonym: "mutation induced by diepoxybutane exposure" EXACT []
is_a: FBcv:0000558 ! epoxy hydrocarbon

[Term]
id: FBcv:0000560
name: diepoxyoctane
namespace: origin_of_mutation
def: "No definition for CHEBI:23705." [CHEBI:23705]
synonym: "1,2:7,8-diepoxyoctane" RELATED [CHEBI:23705]
synonym: "mutation induced by diepoxyoctane exposure" EXACT []
is_a: FBcv:0000558 ! epoxy hydrocarbon

[Term]
id: FBcv:0000561
name: obsolete unclassified chemical
namespace: origin_of_mutation
is_obsolete: true
consider: FBcv:0000525

[Term]
id: FBcv:0000562
name: 1,2:5,6-dibenzanthracene
namespace: origin_of_mutation
def: "No definition for CHEBI:35299." [CHEBI:35299]
synonym: "mutation induced by 1,2:5,6-dibenzanthracene exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000563
name: 1,4-dimethanesulfonoxy-1,4-dimethylbutane
namespace: origin_of_mutation
def: "A methanesulfonate ester that is hexane-2,5-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups (from CHEBI)." [CHEBI:67107]
synonym: "1,4-dimethanesulfonoxy-1:4-dimethylbutane" RELATED []
synonym: "CB2348" RELATED []
synonym: "dimethylmyleran" RELATED [CHEBI:67107]
synonym: "mutation induced by 1,4-dimethanesulfonoxy-1,4-dimethylbutane exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000564
name: 1,4-dimethanesulfonoxybut-2-yne
namespace: origin_of_mutation
def: "Mutation induced by exposure to 1,4-dimethanesulfonoxybut-2-yne." [FBC:MMC]
synonym: "CB2058" RELATED []
synonym: "mutation induced by 1,4-dimethanesulfonoxybut-2-yne exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000565
name: dominance relationship qualifier
namespace: dominance_qualifier
def: "Dominance relationships describe the dependence of the expression of a phenotypic attribute of an allele on the genotype at the locus in question. An allele might be recessive with respect to one phenotypic attribute, but dominant with respect to another." [FBC:rd]
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000566
name: 1,6-dimethylsulfonoxy D-mannitol
namespace: origin_of_mutation
def: "Mutation induced by exposure to 1,6-dimethylsulfonoxy D-mannitol." [FBC:MMC]
synonym: "CB2511" RELATED []
synonym: "mutation induced by 1,6-dimethylsulfonoxy D-mannitol exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000567
name: 1,6-dimethylsulfonoxy L-mannitol
namespace: origin_of_mutation
def: "Mutation induced by exposure to 1,6-dimethylsulfonoxy L-mannitol." [FBC:MMC]
synonym: "CB2628" RELATED []
synonym: "mutation induced by 1,6-dimethylsulfonoxy L-mannitol exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000568
name: 1-amino-2-naphthol-4-sulfonic acid
namespace: origin_of_mutation
def: "No definition for CHEBI:19024." [CHEBI:19024]
synonym: "mutation induced by 1-amino-2-naphthol-4-sulfonic acid exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000569
name: lucanthone
namespace: origin_of_mutation
def: "A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone (from CHEBI)." [CHEBI:51052]
synonym: "1-diethylaminoethylethylamino-4-methyl-thioxanthenone" RELATED []
synonym: "1-{[2-(diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one" RELATED [CHEBI:51052]
synonym: "lucanthone" RELATED [CHEBI:51052]
synonym: "mutation induced by lucanthone exposure" EXACT []
is_a: FBcv:0000551 ! enzyme inhibitor

[Term]
id: FBcv:0000570
name: 2-methoxyethanol
namespace: origin_of_mutation
def: "A hydroxyether that is ethanol substituted by a methoxy group at position 2 (from CHEBI)." [CHEBI:46790]
synonym: "mutation induced by 2-methoxyethanol exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000571
name: 2,5-bis(ethyleneimino)-1,4-benzoquinone
namespace: origin_of_mutation
def: "A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 5 are replaced by aziridin-1-yl groups (from CHEBI)." [CHEBI:19363]
synonym: "2,5,-bisethylene-imine-1,4-benzoquinone" RELATED []
synonym: "mutation induced by 2,5-bis(ethyleneimino)-1,4-benzoquinone exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000572
name: 7-bromomethyl-12-methylbenz[a]anthracene
namespace: origin_of_mutation
def: "A member of the class of tetraphenes that is tetraphene in which the hydrogens at positions 7 and 12 are replaced by bromomethyl and methyl groups, respectively (from CHEBI)." [CHEBI:20787]
synonym: "7-bromomethyl 12 methyl benzalpha anthracine" RELATED []
synonym: "7-bromomethyl-12-methyltetraphene" RELATED [CHEBI:20787]
synonym: "mutation induced by 7-bromomethyl-12-methylbenz[a]anthracene exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000573
name: actinomycin D
namespace: origin_of_mutation
def: "No definition for CHEBI:27666." [CHEBI:27666]
synonym: "mutation induced by actinomycin D exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000574
name: benzo(alpha)pyrene
namespace: origin_of_mutation
def: "An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings (from CHEBI)." [CHEBI:29865]
synonym: "benzo[a]pyrene" RELATED [CHEBI:29865]
synonym: "mutation induced by benzo(alpha)pyrene exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000575
name: caffeine
namespace: origin_of_mutation
def: "A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee (from CHEBI)." [CHEBI:27732]
synonym: "mutation induced by caffeine exposure" EXACT []
is_a: FBcv:0000551 ! enzyme inhibitor

[Term]
id: FBcv:0000576
name: cisplatin
namespace: origin_of_mutation
def: "A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups) (from CHEBI)." [CHEBI:27899]
synonym: "cis-dichlorodiammineplatinum(II)" RELATED []
synonym: "mutation induced by cisplatin exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000577
name: colchicine
namespace: origin_of_mutation
def: "An  alkaloid that is a carbotricyclic compound comprising 5,6,7,9-tetrahydrobenzo[a]heptalene having four methoxy substituents at the 1-, 2-, 3- and 10-positions as well as an oxo group at the 9-position and an acetamido group at the 7-position. It has been isolated from the plants belonging to genus Colchicum (from CHEBI)." [CHEBI:23359]
synonym: "mutation induced by colchicine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000578
name: dimethyl sulfoxide
namespace: origin_of_mutation
def: "A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents (from CHEBI)." [CHEBI:28262]
synonym: "mutation induced by dimethyl sulfoxide exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000579
name: DNA
namespace: origin_of_mutation
def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms (from CHEBI)." [CHEBI:16991]
synonym: "mutation induced by DNA treatment" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000580
name: ethyl ether
namespace: origin_of_mutation
def: "An ether in which the oxygen atom is linked to two ethyl groups (from CHEBI)." [CHEBI:35702]
synonym: "mutation induced by ethyl ether exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000581
name: ethylenimine
namespace: origin_of_mutation
def: "No definition for CHEBI:30969." [CHEBI:30969]
synonym: "EI" RELATED []
synonym: "mutation induced by ethylenimine exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000582
name: ethylene oxide
namespace: origin_of_mutation
def: "A  saturated organic heteromonocyclic parent that is a three-membered heterocycle of two carbon atoms and one oxygen atom (from CHEBI)." [CHEBI:27561]
synonym: "ethylene oxide" RELATED [CHEBI:27561]
synonym: "mutation induced by ethylene oxide exposure" EXACT []
synonym: "oxirane" RELATED [CHEBI:27561]
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000583
name: fagaronine
namespace: origin_of_mutation
def: "No definition for CHEBI:28954." [CHEBI:28954]
synonym: "mutation induced by fagaronine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000584
name: formaldehyde
namespace: origin_of_mutation
def: "An aldehyde resulting from the formal oxidation of methanol (from CHEBI)." [CHEBI:16842]
synonym: "mutation induced by formaldehyde exposure" EXACT []
is_a: FBcv:0000551 ! enzyme inhibitor

[Term]
id: FBcv:0000585
name: hesperidine
namespace: origin_of_mutation
def: "A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage (from CHEBI)." [CHEBI:28775]
synonym: "hesperidin" RELATED [CHEBI:28775]
synonym: "mutation induced by hesperidine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000586
name: hexamethylmelamine
namespace: origin_of_mutation
def: "No definition for CHEBI:24564." [CHEBI:24564]
synonym: "altretamine" RELATED []
synonym: "HMM" RELATED []
synonym: "mutation induced by hexamethylmelamine exposure" EXACT []
synonym: "mutation induced by HMM exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000587
name: hexamethylphosphoramide
namespace: origin_of_mutation
def: "No definition for CHEBI:24565." [CHEBI:24565]
synonym: "HMPA" RELATED []
synonym: "mutation induced by hexamethylphosphoramide exposure" EXACT []
synonym: "mutation induced by HMPA exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000588
name: iodine
namespace: origin_of_mutation
def: "Chemical element with atomic number 53 (from CHEBI)." [CHEBI:24859]
synonym: "mutation induced by iodine exposure" EXACT []
is_a: FBcv:0000553 ! inorganic compound

[Term]
id: FBcv:0000589
name: Janus green B
namespace: origin_of_mutation
def: "No definition for CHEBI:21184." [CHEBI:21184]
synonym: "Janus green B chloride" RELATED [CHEBI:21184]
synonym: "mutation induced by Janus green B exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000590
name: methoxy diethylnitrosamine
namespace: origin_of_mutation
def: "No definition for CHEBI:25234." [CHEBI:25234]
comment: Mapped to CHEBI:25234 (1-methoxy-N-nitrosodiethylamine) based on synonym of nitrosodiethylamine being diethylnitrosamine and CHEBI:25234 being classified as a mutagen.
synonym: "1-methoxy-N-nitrosodiethylamine" RELATED [CHEBI:25234]
synonym: "mutation induced by methoxy diethylnitrosamine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000591
name: natural gas
namespace: origin_of_mutation
def: "Mutation induced by exposure to natural gas." [FBC:MMC]
synonym: "mutation induced by natural gas exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000592
name: nitrosomethyl urea
namespace: origin_of_mutation
def: "A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups (from CHEBI)." [CHEBI:50102]
synonym: "MNU" RELATED []
synonym: "mutation induced by MNU exposure" EXACT []
synonym: "mutation induced by nitrosomethyl urea exposure" EXACT []
synonym: "N-methyl-N-nitrosourea" RELATED [CHEBI:50102]
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000593
name: N-nitrosodimethylamine
namespace: origin_of_mutation
def: "No definition for CHEBI:35807." [CHEBI:35807]
synonym: "DMN" RELATED []
synonym: "mutation induced by DMN exposure" EXACT []
synonym: "mutation induced by N-nitrosodimethylamine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000594
name: p-N,N-di(2-chloroethyl)aminophenylvaleric acid
namespace: origin_of_mutation
def: "No definition for CHEBI:25813." [CHEBI:25813]
synonym: "CB1356" RELATED []
synonym: "mutation induced by p-N,N-di(2-chloroethyl)aminophenylvaleric acid exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000595
name: p-N,N-di-(2-chloroethyl)amino-D-phenylalanine
namespace: origin_of_mutation
def: "No definition for CHEBI:25814." [CHEBI:25814]
synonym: "CB3026" RELATED []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)amino-D-phenylalanine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000596
name: p-N,N-di-(2-chloroethyl)amino-DL-phenylalanine
namespace: origin_of_mutation
def: "A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring (from CHEBI)." [CHEBI:28876]
synonym: "CB3007" RELATED []
synonym: "melphalan" RELATED [CHEBI:28876]
synonym: "mutation induced by melphalan exposure" EXACT []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)amino-DL-phenylalanine exposure" EXACT []
is_a: FBcv:0000813 ! nitrogen mustard

[Term]
id: FBcv:0000597
name: p-N,N-di-(2-chloroethyl)amino-L-phenylalanine
namespace: origin_of_mutation
def: "No definition for CHEBI:25816." [CHEBI:25816]
synonym: "CB3025" RELATED []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)amino-L-phenylalanine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000598
name: obsolete dominant temperature-sensitive lethal balancer
comment: Consider - FBsv:0001009.
is_obsolete: true

[Term]
id: FBcv:0000599
name: p-N,N-di-(2-chloroethyl)aminophenylethylamine
namespace: origin_of_mutation
def: "No definition for CHEBI:25818." [CHEBI:25818]
synonym: "CB3034" RELATED []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)aminophenylethylamine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000600
name: p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine
namespace: origin_of_mutation
def: "No definition for CHEBI:25829." [CHEBI:25829]
synonym: "CB305" RELATED []
synonym: "mutation induced by p-p'-N,N-di(2-chloroethyl)aminophenoxyphenylalanine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000601
name: quinhydrone
namespace: origin_of_mutation
def: "No definition for CHEBI:26491." [CHEBI:26491]
synonym: "mutation induced by quinhydrone exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000602
name: S-2-chloroethylcysteine
namespace: origin_of_mutation
def: "No definition for CHEBI:22025." [CHEBI:22025]
synonym: "CB1592" RELATED []
synonym: "mutation induced by S-2-chloroethylcysteine exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000603
name: styryl quinoline
namespace: origin_of_mutation
def: "No definition for CHEBI:26800." [CHEBI:26800]
synonym: "CB3086" RELATED []
synonym: "mutation induced by styryl quinoline exposure" EXACT []
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000604
name: triaziquone
namespace: origin_of_mutation
def: "A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups (from CHEBI)." [CHEBI:27090]
synonym: "mutation induced by triaziquone exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000605
name: triethylenemelamine
namespace: origin_of_mutation
def: "No definition for CHEBI:27919." [CHEBI:27919]
synonym: "CB1246" RELATED []
synonym: "mutation induced by triethylenemelamine exposure" EXACT []
synonym: "TEM" RELATED []
synonym: "tretamine" RELATED [CHEBI:27919]
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000606
name: obsolete allele assay method
namespace: mode_of_assay
def: "Assay method used to generate an allele." [FBC:MMC]
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000607
name: obsolete In transgenic Drosophila
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000608
name: obsolete Whole-organism transient assay
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000609
name: obsolete Drosophila cell culture
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000610
name: obsolete In transgenic Drosophila (allele of one drosophilid species in genome of another drosophilid)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000611
name: obsolete Whole-organism transient assay (allele from one drosophilid species assayed in another drosophilid)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000612
name: obsolete In transgenic Drosophila (allele of foreign species in genome of drosophilid)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000613
name: obsolete Whole-organism transient assay (allele of foreign species assayed in drosophilid)
namespace: mode_of_assay
comment: This term has been obsoleted because it is no longer used and relevant. mc151005
is_obsolete: true
consider: FBcv:0000807

[Term]
id: FBcv:0000614
name: obsolete stock descriptor
comment: Consider - FBsv:0000000.
is_obsolete: true

[Term]
id: FBcv:0000615
name: obsolete extracted wild-type chromosome
is_obsolete: true

[Term]
id: FBcv:0000616
name: obsolete laboratory stock
comment: I don't think this is a useful term.
is_obsolete: true

[Term]
id: FBcv:0000617
name: obsolete selected wild-type stock
is_obsolete: true

[Term]
id: FBcv:0000618
name: obsolete wild-type stock
comment: Consider - FBsv:0001005.
is_obsolete: true

[Term]
id: FBcv:0000619
name: obsolete isogenic stock
comment: Consider - FBsv:0001002.
is_obsolete: true

[Term]
id: FBcv:0000620
name: genetic interaction qualifier
namespace: genetic_interaction_type
def: "Qualifier that describes the relation between two phenotypes that are due to genotypes g1 and g2." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000621
name: suppressor
namespace: genetic_interaction_type
def: "The genotype g1 is a suppressor of genotype g2 if (and only if) the phenotype due to g2 is made less severe by g1." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
comment: Not used directly in curation, but automatically inferred from its inverse (suppressible).
subset: do_not_manually_annotate
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000622
name: suppressible
namespace: genetic_interaction_type
def: "A phenotype due to genotype g1 is suppressible by genotype g2 if the if the phenotype due to the genotype g1g2 is less severe than that due to g1 alone." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000623
name: enhancer
namespace: genetic_interaction_type
def: "Genotype g1 is enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
comment: Not used directly in curation, but automatically inferred from its inverse (enhanceable).
subset: do_not_manually_annotate
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000624
name: enhanceable
namespace: genetic_interaction_type
def: "A phenotype due to genotype g1 is enhanceable by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000625
name: non-enhancer
namespace: genetic_interaction_type
def: "Genotype g1 is a non-enhancer of genotype g2 if (and only if) the phenotype due to the genotype g1g2 is not more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." [FBC:MMC, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
comment: Not used directly in curation, but automatically inferred from its inverse (non-enhanceable).
subset: do_not_manually_annotate
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000626
name: non-enhanceable
namespace: genetic_interaction_type
def: "A phenotype due to genotype g1 is non-enhanceable by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is no more severe than the sum of phenotypes due to g1 and g2, where all comparisons are under identical environmental conditions." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000627
name: non-suppressor
namespace: genetic_interaction_type
def: "The genotype g1 is a non-suppressor of genotype g2 if (and only if) the phenotype due to g2 is not made less severe by g1." [FBC:MMC, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
comment: Not used directly in curation, but automatically inferred from its inverse (non-suppressible).
subset: do_not_manually_annotate
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000628
name: non-suppressible
namespace: genetic_interaction_type
def: "A phenotype due to genotype g1 is non-suppressible by genotype g2 if (and only if) the phenotype due to the genotype g1g2 is no less severe than the phenotype due to g1 alone." [FBC:DOS, FlyBase:FBrf0000957, ISBN:978-0-387-52054-4]
is_a: FBcv:0000620 ! genetic interaction qualifier

[Term]
id: FBcv:0000629
name: obsolete dominant temperature-sensitive lethal balancer for chromosome 2
is_obsolete: true

[Term]
id: FBcv:0000630
name: obsolete dominant temperature-sensitive lethal balancer for chromosome 3
is_obsolete: true

[Term]
id: FBcv:0000631
name: obsolete DrosDel Project deficiency core kit stock
is_obsolete: true

[Term]
id: FBcv:0000632
name: obsolete Bloomington Stock Center deficiency kit stock
comment: Consider - FBsv:0000601.
is_obsolete: true

[Term]
id: FBcv:0000633
name: obsolete Exelixis deficiency kit stock
is_obsolete: true

[Term]
id: FBcv:0000634
name: obsolete duplication kit stock
is_obsolete: true

[Term]
id: FBcv:0000635
name: obsolete Cambridge 2 duplication kit stock
comment: Consider - FBsv:0000603.
is_obsolete: true

[Term]
id: FBcv:0000636
name: obsolete Bloomington duplication kit stock
comment: Consider - FBsv:0000602.
is_obsolete: true

[Term]
id: FBcv:0000637
name: obsolete Gene Disruption Project stock
is_obsolete: true

[Term]
id: FBcv:0000638
name: obsolete sequenced strain
comment: Consider - FBsv:0001003.
is_obsolete: true

[Term]
id: FBcv:0000639
name: obsolete Golic gene replacement kit stock
comment: Consider - FBsv:0000604.
is_obsolete: true

[Term]
id: FBcv:0000640
name: obsolete Golic laboratory gene replacement kit stock
is_obsolete: true

[Term]
id: FBcv:0000641
name: obsolete stock by cytotype
is_obsolete: true

[Term]
id: FBcv:0000642
name: obsolete H cytotype stock
is_obsolete: true

[Term]
id: FBcv:0000643
name: obsolete hobo family transposable element insertions present
is_obsolete: true

[Term]
id: FBcv:0000644
name: obsolete hobo family transposable element insertions absent
is_obsolete: true

[Term]
id: FBcv:0000645
name: obsolete P cytotype stock
is_obsolete: true

[Term]
id: FBcv:0000646
name: obsolete P-element family transposable element insertions absent
is_obsolete: true

[Term]
id: FBcv:0000647
name: obsolete P-element family transposable element insertions present
is_obsolete: true

[Term]
id: FBcv:0000648
name: obsolete mapping stock
is_obsolete: true

[Term]
id: FBcv:0000649
name: obsolete visible allele recombination mapping stock
is_obsolete: true

[Term]
id: FBcv:0000650
name: editorial
namespace: pub_type
def: "Work consisting of a statement of the opinions, beliefs, and policy of the editor or publisher of a journal, usually on current matters of medical or scientific significance to the medical community or society at large." [MeSH:D016421]
xref: MeSH:D016421
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000651
name: obsolete meeting report
namespace: pub_type
comment: This term was obsoleted to conform with the MeSH terms used by PubMed. Please use 'FBcv:0000199
is_obsolete: true
replaced_by: FBcv:0000199

[Term]
id: FBcv:0000652
name: compendium
namespace: pub_type
def: "A publication containing a collection of separate articles written by distinct authors." [FBC:SM]
synonym: "multipub" EXACT [FBC:SM]
synonym: "multipublication" EXACT [FBC:SM]
synonym: "Parent publication" EXACT [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000653
name: subset
namespace: expression_qualifier
def: "Restricted to unknown subtype(s) of a specified type." [FBC:DS]
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000654
name: embryonic pattern qualifier
namespace: embryonic_pattern_qualifier
def: "Qualifier that describes the expression pattern of an embryo." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000052 ! spatial qualifier

[Term]
id: FBcv:0000655
name: obsolete Vienna Drosophila RNAi Center
comment: Consider - FBsv:0000107.
synonym: "VDRC" EXACT []
synonym: "Vienna" EXACT []
is_obsolete: true

[Term]
id: FBcv:0000656
name: obsolete frozen specimen
comment: Consider - FBsv:0000008.
is_obsolete: true

[Term]
id: FBcv:0000657
name: obsolete mutant stock
is_obsolete: true

[Term]
id: FBcv:0000658
name: obsolete DrosDel Project deficiency stock
is_obsolete: true

[Term]
id: FBcv:0000659
name: obsolete deficiency stock
is_obsolete: true

[Term]
id: FBcv:0000660
name: obsolete inbred line
comment: Consider - FBsv:0000501.
is_obsolete: true

[Term]
id: FBcv:0000661
name: obsolete isofemale line
comment: Consider - FBsv:0000502.
is_obsolete: true

[Term]
id: FBcv:0000662
name: obsolete recently collected stock
def: "A stock established from flies collected in the wild within the past 3 years." [FBC:KM]
comment: Consider - FBsv:0000504.
is_obsolete: true

[Term]
id: FBcv:0000663
name: obsolete transposable element-containing stock
is_obsolete: true

[Term]
id: FBcv:0000664
name: obsolete duplication stock
is_obsolete: true

[Term]
id: FBcv:0000665
name: abnormal body size
namespace: phenotypic_class
def: "Phenotype that is an abnormality in body size compared to wild-type animals raised under the same conditions as the animals exhibiting the phenotype." [FBC:DOS]
synonym: "body size defective" EXACT []
is_a: FBcv:0000354 ! visible
is_a: FBcv:0000357 ! abnormal size

[Term]
id: FBcv:0000666
name: obsolete conference proceedings
namespace: pub_type
comment: This term was obsoleted to conform with the MeSH terms used by PubMed. Please use 'FBcv:0000199
is_obsolete: true
replaced_by: FBcv:0000199

[Term]
id: FBcv:0000667
name: website
namespace: pub_type
def: "A set of related web pages containing content such as text, images, video, audio, etc., prepared and maintained as a collection of information on a particular subject." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000668
name: abnormal cell adhesion
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.'" [FBC:DOS, GOC:hb, GOC:pf]
subset: fbcvsubset_mgiribbons
synonym: "cell adhesion defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000669
name: abnormal hatching behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in hatching behavior (GO:0035187). 'hatching behavior' is defined as: 'The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell.'" [FBC:DOS, GOC:pr, PMID:10436051]
synonym: "hatching behavior defective" EXACT []
synonym: "hatching behaviour defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0000670
name: abnormal eclosion
namespace: phenotypic_class
def: "Phenotype that is any abnormality in eclosion (GO:0007562). 'eclosion' is defined as: 'The emergence of an adult insect from a pupa case.'" [FBC:DOS, GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461]
subset: fbcvsubset_mgiribbons
synonym: "eclosion defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000671
name: abnormal cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell cycle (GO:0007049). 'cell cycle' is defined as: 'The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.'" [FBC:DOS, GOC:go_curators, GOC:mtg_cell_cycle]
subset: fbcvsubset_mgiribbons
synonym: "cell cycle defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000672
name: abnormal endomitotic cell cycle
namespace: phenotypic_class
def: "Phenotype that is any abnormality in endomitotic cell cycle (GO:0007113). 'endomitotic cell cycle' is defined as: 'A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.'" [FBC:DOS, GOC:curators, GOC:dos, GOC:expert_vm]
synonym: "endocycle defective" EXACT []
synonym: "endomitotic cell cycle defective" EXACT []
is_a: FBcv:0000432 ! abnormal mitotic cell cycle

[Term]
id: FBcv:0000673
name: obsolete sequenced whole genome stock
comment: Consider - FBsv:0001003.
is_obsolete: true

[Term]
id: FBcv:0000674
name: obsolete phiC31 based integration system
is_obsolete: true

[Term]
id: FBcv:0000675
name: obsolete phiC31 docking site stock
is_obsolete: true

[Term]
id: FBcv:0000676
name: obsolete multi-female collection
comment: Consider - FBsv:0000503.
is_obsolete: true

[Term]
id: FBcv:0000677
name: 60-70% egg length
namespace: spatial_qualifier
def: "60-70% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000678
name: 80-100% egg length
namespace: spatial_qualifier
def: "80-100% of egg length from the posterior tip (0%) of the egg or pre-gastrula embryo." [FBC:DOS]
is_a: FBcv:0000074 ! egg length

[Term]
id: FBcv:0000679
name: abnormal circadian behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in circadian behavior (GO:0048512). 'circadian behavior' is defined as: 'The specific behavior of an organism that recurs with a regularity of approximately 24 hours.'" [FBC:DOS, GOC:bf, GOC:go_curators, GOC:pr]
synonym: "circadian behavior defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
is_a: FBcv:0000394 ! abnormal circadian rhythm

[Term]
id: FBcv:0000680
name: abnormal proboscis extension reflex
namespace: phenotypic_class
def: "Phenotype that is any abnormality in proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'" [FB:FBrf0044924, FBC:DOS, GOC:jid]
synonym: "proboscis extension reflex defective" EXACT []
is_a: FBcv:0000403 ! abnormal chemosensory behavior

[Term]
id: FBcv:0000681
name: abnormal sensory perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception (GO:0007600). 'sensory perception' is defined as: 'The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.'" [FBC:DOS, GOC:ai, GOC:dph]
subset: fbcvsubset_mgiribbons
synonym: "sensory perception defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000682
name: abnormal touch perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of touch (GO:0050975). 'sensory perception of touch' is defined as: 'The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).'" [FBC:DOS, GOC:ai]
synonym: "touch perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0000683
name: abnormal temperature response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to temperature stimulus (GO:0009266). 'response to temperature stimulus' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.'" [FBC:DOS, GOC:hb]
subset: fbcvsubset_mgiribbons
synonym: "temperature response defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000684
name: abnormal cold stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to cold (GO:0009409). 'response to cold' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.'" [FBC:DOS, GOC:lr]
synonym: "cold stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response
is_a: FBcv:0000683 ! abnormal temperature response

[Term]
id: FBcv:0000685
name: parental effect
namespace: genotype_to_phenotype_relation
def: "Parental effects describe the dependence of the expression of a phenotypic attribute of an allele on the parent from which that allele is inherited." [FBC:rd]
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000686
name: abnormal axis specification
namespace: phenotypic_class
def: "Phenotype that is any abnormality in axis specification (GO:0009798). 'axis specification' is defined as: 'The establishment, maintenance and elaboration of a pattern along a line or around a point.'" [FBC:DOS, GOC:dph, GOC:go_curators, GOC:isa_complete]
comment: This phenotypic class does not encompass planar polarity.
subset: fbcvsubset_mgiribbons
synonym: "axis specification defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000687
name: balancer descriptor
def: "Descriptor that relates to aspects of a balancer." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0000688
name: amorphic allele
namespace: allele_class
def: "An allele that completely lacks function, coding either for a completely inactive gene product or none at all." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "amorph" RELATED []
synonym: "null" RELATED []
is_a: FBcv:0000287 ! loss of function allele

[Term]
id: FBcv:0000689
name: amorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to completely lack function, producing either a completely inactive gene product or none at all." [FlyBase:FBrf0049147]
synonym: "molecular null" EXACT []
is_a: FBcv:0000688 ! amorphic allele

[Term]
id: FBcv:0000690
name: hypomorphic allele
namespace: allele_class
def: "Allele that makes a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "hypomorph" EXACT []
is_a: FBcv:0000287 ! loss of function allele

[Term]
id: FBcv:0000691
name: hypomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FlyBase:FBrf0049147]
is_a: FBcv:0000690 ! hypomorphic allele

[Term]
id: FBcv:0000692
name: neomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern compared to wild-type." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000697 ! neomorphic allele

[Term]
id: FBcv:0000693
name: hypermorphic allele - molecular evidence
namespace: allele_class
def: "Allele shown by molecular evidence to make either a functionally wild-type gene product at increased levels or a gene product with the same function as wild-type but with increased activity." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000696 ! hypermorphic allele

[Term]
id: FBcv:0000694
name: antimorphic allele - molecular evidence
namespace: allele_class
def: "An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product." [FlyBase:FBrf0049147]
synonym: "dominant negative" RELATED []
is_a: FBcv:0000695 ! antimorphic allele

[Term]
id: FBcv:0000695
name: antimorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is antagonistic to the function of the wild-type gene product." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "antimorph" RELATED []
is_a: FBcv:0000290 ! gain of function allele

[Term]
id: FBcv:0000696
name: hypermorphic allele
namespace: allele_class
def: "An allele that makes either increased amounts of a normal gene product or a gene product with normal function but increased activity compared to wild-type." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "hypermorph" RELATED []
is_a: FBcv:0000290 ! gain of function allele

[Term]
id: FBcv:0000697
name: neomorphic allele
namespace: allele_class
def: "An allele that makes a gene product with a novel function or expression pattern compared to wild-type." [FlyBase:FBrf0002371, FlyBase:FBrf0049147]
synonym: "neomorph" RELATED []
is_a: FBcv:0000290 ! gain of function allele

[Term]
id: FBcv:0000698
name: embryonic/larval segmentation phenotype
namespace: phenotypic_class
def: "A phenotype that is a disruption in the wild-type pattern of segments or parasegments of the embryo or larva." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000699
name: pair rule phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete or partial loss of alternate segments or parasegments." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000698 ! embryonic/larval segmentation phenotype

[Term]
id: FBcv:0000700
name: even pair-rule phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete or partial loss of even segments." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000699 ! pair rule phenotype

[Term]
id: FBcv:0000701
name: odd pair-rule phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete or partial loss of odd segments." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000699 ! pair rule phenotype

[Term]
id: FBcv:0000702
name: segment polarity phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype in which some fraction of each segment (along the anterior-posterior axis) is deleted and replaced by a mirror image duplication of the remaining part of the segment." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000698 ! embryonic/larval segmentation phenotype

[Term]
id: FBcv:0000703
name: gap phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete loss of a contiguous stretch of 2 or more segments." [FlyBase:FBrf0035438]
comment: Commonly assayed on the basis of phenotypic effects on segmentally repeated cuticular patterns.
is_a: FBcv:0000698 ! embryonic/larval segmentation phenotype

[Term]
id: FBcv:0000704
name: chemical conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence or absence of some specific chemical whose presence or absence does not induce the same defect in wild-type animals." [FBC:DOS]
is_a: FBcv:0000309 ! conditional

[Term]
id: FBcv:0000705
name: abnormal sleep
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sleep (GO:0030431). 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.'" [FBC:DOS, ISBN:0192800981]
subset: fbcvsubset_mgiribbons
synonym: "sleep defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000706
name: abnormal diapause
namespace: phenotypic_class
def: "Phenotype that is any abnormality in entry into diapause (GO:0055115). 'entry into diapause' is defined as: 'The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation.'" [FBC:DOS, GOC:ds, GOC:jid, GOC:mah]
synonym: "diapause defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000707
name: abnormal reproductive diapause
namespace: phenotypic_class
def: "Phenotype that is any abnormality in entry into reproductive diapause (GO:0055116). 'entry into reproductive diapause' is defined as: 'The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli.'" [FBC:DOS, GOC:ds, GOC:jid, GOC:mah]
synonym: "reproductive diapause defective" EXACT []
is_a: FBcv:0000706 ! abnormal diapause

[Term]
id: FBcv:0000708
name: abnormal starvation stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to starvation (GO:0042594). 'response to starvation' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.'" [FBC:DOS, GOC:go_curators]
synonym: "starvation stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000709
name: abnormal cell number
namespace: phenotypic_class
def: "Phenotype that is an increase or decrease in the number of cells in a whole animal or in some specific organ, tissue or clone of cells compared to wild-type. This phenotype is not necessarily accompanied by defects in cell growth - there may be a greater or lesser number of cells in an otherwise normal volume of tissue." [FBC:DOS]
subset: fbcvsubset_mgiribbons
synonym: "cell number defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000710
name: gene targeting by homologous recombination
namespace: origin_of_mutation
def: "Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double stranded break in an engineered donor construct that contains sequence homologous to the target gene." [FBC:MC, FlyBase:FBrf0202435]
comment: Strictly, homologous recombinational repair (GO:0000724) defines only the endogenous process, not its use for engineered gene targeting.
synonym: "change induced by gene targeting via homologous recombination" EXACT []
is_a: FBcv:0000470 ! recombination

[Term]
id: FBcv:0000711
name: ends-out gene targeting
namespace: origin_of_mutation
def: "Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break on both sides of the homologous region in an engineered donor sequence. This double-strand break is usually generated by cutting at a single site adjacent to the homologous region in a circularized donor sequence. This typically generates a simple targeted replacement of the target sequence by the donor sequence. However, more complicated outcomes are possible." [FBC:MC, FlyBase:FBrf0167363, FlyBase:FBrf0202435]
synonym: "change induced by ends-out gene targeting" EXACT []
is_a: FBcv:0000710 ! gene targeting by homologous recombination

[Term]
id: FBcv:0000712
name: ends-in gene targeting
namespace: origin_of_mutation
def: "Change of a genomic sequence via homologous recombinational repair (GO:0000724) that is induced by a double strand break within an engineered homologous donor sequence. This typically generates a tandem duplication of the homologous sequence from the donor, separated by the remainder of the incoming donor DNA. However, more complicated outcomes are possible." [FBC:MC, FlyBase:FBrf0167363, FlyBase:FBrf0202435]
synonym: "change induced by ends-in gene targeting" EXACT []
is_a: FBcv:0000710 ! gene targeting by homologous recombination

[Term]
id: FBcv:0000713
name: jumpless
namespace: phenotypic_class
def: "Phenotype that is a inability to jump. This may be due to neurological or muscular defects." [FBC:DOS]
is_a: FBcv:0000415 ! abnormal jumping

[Term]
id: FBcv:0000714
name: nutrition conditional
namespace: environmental_qualifier
def: "Phenotype only expressed under some specific nutritional regime." [FBC:DOS]
is_a: FBcv:0000309 ! conditional

[Term]
id: FBcv:0000715
name: calorie restriction conditional
namespace: environmental_qualifier
def: "Phenotype only expressed under conditions where calorie intake is restricted." [FBC:DOS]
is_a: FBcv:0000714 ! nutrition conditional

[Term]
id: FBcv:0000716
name: abnormal cell migration
namespace: phenotypic_class
def: "Phenotype that is any abnormality in cell migration (GO:0016477). 'cell migration' is defined as: 'The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.'" [FBC:DOS, GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
subset: fbcvsubset_mgiribbons
synonym: "cell migration defective" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0000717
name: increased cell growth rate
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of cell growth (GO:0016049) in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
is_a: FBcv:0000427 ! abnormal cell growth

[Term]
id: FBcv:0000718
name: decreased cell growth rate
namespace: phenotypic_class
def: "Phenotype that is an decrease in any kind of rate (e.g. speed, frequency) of cell growth (GO:0016049) in a whole animal or in some specific organ tissue or clone of cells compared to wild-type." [FBC:DOS]
synonym: "reduced cell growth rate" EXACT []
is_a: FBcv:0000427 ! abnormal cell growth

[Term]
id: FBcv:0000719
name: atrophy
namespace: phenotypic_class
def: "Phenotype that is a decrease in size of an initially normally sized organ or tissue due to wasting away of cells." [FBC:DOS]
is_a: FBcv:0007508 ! decreased size

[Term]
id: FBcv:0000720
name: abnormal jump response
namespace: phenotypic_class
def: "Phenotype that is any abnormality or in or absence of a jump response (GO:0007630). The jump response in Drosophila is a reflex escape response that can be triggered by a number of signals including odor and light. Standard assays are commonly used to test odor and light induced jump response." [FlyBase:FBrf0187887, FlyBase:FBrf0191819]
synonym: "jump response defective" EXACT []
is_a: FBcv:0000415 ! abnormal jumping
is_a: FBcv:0007529 ! abnormal adult locomotory behavior

[Term]
id: FBcv:0000721
name: abnormal mating behavior
namespace: phenotypic_class
def: "Phenotype that is any abnormality in mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'" [FBC:DOS, GOC:ai, GOC:dph]
synonym: "mating behavior defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior
is_a: FBcv:0000400 ! abnormal mating

[Term]
id: FBcv:0000722
name: somatic clone - Minute background
namespace: clone_qualifier
def: "A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that is part of and derived from an animal with a different genotype that includes being Minute +/-." [FBC:DOS]
is_a: FBcv:0000336 ! somatic clone

[Term]
id: FBcv:0000723
name: neoplasia
namespace: phenotypic_class
def: "Phenotype that consists of abnormal growth of a tissue or organ due to increased numbers of cells, but in which the affected tissue or organ does not maintain its normal form." [FBC:DOS]
synonym: "neoplasm" NARROW []
synonym: "neoplastic" NARROW []
synonym: "tumorigenesis" NARROW []
synonym: "tumorigenic" NARROW []
is_a: FBcv:0000357 ! abnormal size
is_a: FBcv:0000362 ! increased cell number

[Term]
id: FBcv:0000724
name: hypoplasia
namespace: phenotypic_class
def: "Phenotype that is a reduction in size of an organ or tissue compared to wild-type due to reduced numbers of cells being produced during its development or growth." [FBC:DOS]
comment: This term should not be used where an organ or tissue is reduced in size due to the wasting away of existing cells.
is_a: FBcv:0000359 ! decreased cell number

[Term]
id: FBcv:0000725
name: abnormal oxidative stress response
namespace: phenotypic_class
def: "Phenotype that is any abnormality in response to oxidative stress (GO:0006979). 'response to oxidative stress' is defined as: 'Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.'" [FBC:DOS, GOC:jl, PMID:12115731]
synonym: "oxidative stress response defective" EXACT []
is_a: FBcv:0000408 ! abnormal stress response

[Term]
id: FBcv:0000726
name: virgin female
namespace: sex_qualifier
def: "Expressed in virgin females." [FBC:DOS]
comment: May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in virgin females.
is_a: FBcv:0000334 ! female

[Term]
id: FBcv:0000727
name: mated female
namespace: sex_qualifier
def: "Expressed in mated females." [FBC:DOS]
comment: May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in mated females.
is_a: FBcv:0000334 ! female

[Term]
id: FBcv:0000728
name: virgin male
namespace: sex_qualifier
def: "Expressed in virgin males." [FBC:DOS]
comment: May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in virgin males.
is_a: FBcv:0000333 ! male

[Term]
id: FBcv:0000729
name: mated male
namespace: sex_qualifier
def: "Expressed in mated males." [FBC:DOS]
comment: May be used as a qualifier for gene or transgene expression or phenotype. Note - its use does not imply expression (of gene or phenotype) exclusively in mated females.
is_a: FBcv:0000333 ! male

[Term]
id: FBcv:0000730
name: virgin female limited
namespace: sex_qualifier
def: "Expression is limited to virgin females." [FBC:DOS]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000308 ! female limited

[Term]
id: FBcv:0000731
name: mated female limited
namespace: sex_qualifier
def: "Expression is limited to mated females." [FBC:DOS]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000308 ! female limited

[Term]
id: FBcv:0000732
name: mated male limited
namespace: sex_qualifier
def: "Expression is limited to mated males." [FBC:DOS]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000307 ! male limited

[Term]
id: FBcv:0000733
name: virgin male limited
namespace: sex_qualifier
def: "Expression is limited to virgin males." [FBC:DOS]
comment: May be used to qualify expression of phenotypes or of genes, transgenes etc.
is_a: FBcv:0000307 ! male limited

[Term]
id: FBcv:0000734
name: terminal phenotype
namespace: phenotypic_class
def: "Embryonic/larval segmentation phenotype that is the complete or partial loss of terminal regions of the embryo/larva: the acron, telson and immediately adjacent segments." [FBC:DOS]
is_a: FBcv:0000698 ! embryonic/larval segmentation phenotype

[Term]
id: FBcv:0000735
name: N-nitrosodiethylamine
namespace: origin_of_mutation
def: "A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom (from CHEBI)." [CHEBI:34873]
synonym: "mutation induced by N-nitrosodiethylamine exposure" EXACT []
synonym: "NDEA" RELATED [FlyBase:FBrf0139766]
is_a: FBcv:0000525 ! chemical

[Term]
id: FBcv:0000736
name: heat sensitive amorphic allele
namespace: allele_class
def: "An allele that completely lacks function (i.e. whose gene productive is completely inactive) at high temperatures, but that retains at least some function at lower temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000739 ! temperature conditional amorphic allele
is_a: FBcv:0000746 ! heat sensitive loss of function allele

[Term]
id: FBcv:0000737
name: temperature conditional amorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to completely lack function at some temperatures (restrictive temperatures) but not others (permissive temperatures) from the observation that addition of extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy)." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000288 ! amorphic allele - genetic evidence
is_a: FBcv:0000739 ! temperature conditional amorphic allele

[Term]
id: FBcv:0000738
name: edited book
namespace: pub_type
def: "A publication that is not issued on a regular, ongoing basis containing separate articles or chapters (typically reviews) written by different authors on a single subject or related subjects, overseen by one or more editors." [FBC:SM]
is_a: FBcv:0000652 ! compendium

[Term]
id: FBcv:0000739
name: temperature conditional amorphic allele
namespace: allele_class
def: "An allele that completely lacks function (i.e. whose gene productive is completely inactive) at some temperatures, but not others." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000688 ! amorphic allele
is_a: FBcv:0000745 ! temperature conditional loss of function allele

[Term]
id: FBcv:0000740
name: cold sensitive amorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to completely lack function at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures) from the observation that adding extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy)." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000737 ! temperature conditional amorphic allele - genetic evidence
is_a: FBcv:0001003 ! cold sensitive amorphic allele

[Term]
id: FBcv:0000741
name: heat sensitive amorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to completely lack function at high temperatures (restrictive temperatures) but not at low temperatures (permissive temperatures) from the observation that adding extra copies in the genome has no effect on the phenotype at the restrictive temperatures. Most commonly, evidence takes the form of the observation that the phenotype of homozygotes (2 copies) is identical to that seen when the allele is in trans to a deletion of the gene (1 copy)." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000736 ! heat sensitive amorphic allele
is_a: FBcv:0000737 ! temperature conditional amorphic allele - genetic evidence

[Term]
id: FBcv:0000742
name: cold sensitive amorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to completely lack function at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures)." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000744 ! temperature conditional amorphic allele - molecular evidence
is_a: FBcv:0001003 ! cold sensitive amorphic allele

[Term]
id: FBcv:0000743
name: heat sensitive amorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to completely lack function at high temperatures (restrictive temperatures) but not at low temperatures (permissive temperatures)." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000736 ! heat sensitive amorphic allele
is_a: FBcv:0000744 ! temperature conditional amorphic allele - molecular evidence

[Term]
id: FBcv:0000744
name: temperature conditional amorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to completely lack function at some temperatures (restrictive temperatures) but not at others (permissive temperatures)." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000689 ! amorphic allele - molecular evidence
is_a: FBcv:0000739 ! temperature conditional amorphic allele

[Term]
id: FBcv:0000745
name: temperature conditional loss of function allele
namespace: allele_class
def: "An allele that at some temperatures but not others either makes no functional gene product or makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000287 ! loss of function allele
relationship: conditionality FBcv:0000310 ! temperature conditional

[Term]
id: FBcv:0000746
name: heat sensitive loss of function allele
namespace: allele_class
def: "An allele that at high temperatures but not low temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000745 ! temperature conditional loss of function allele
relationship: conditionality FBcv:0000311 ! heat sensitive

[Term]
id: FBcv:0000747
name: cold sensitive loss of function allele
namespace: allele_class
def: "An allele that at low temperatures but not high temperatures, either makes no functional gene product, makes reduced levels of a normally functioning gene product or makes a gene product with reduced activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000745 ! temperature conditional loss of function allele
relationship: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0000748
name: temperature conditional gain of function allele
namespace: allele_class
def: "An allele that at some temperatures but not others, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000290 ! gain of function allele
relationship: conditionality FBcv:0000310 ! temperature conditional

[Term]
id: FBcv:0000749
name: heat sensitive gain of function allele
namespace: allele_class
def: "An allele that at high temperatures but not low temperatures, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000748 ! temperature conditional gain of function allele
relationship: conditionality FBcv:0000311 ! heat sensitive

[Term]
id: FBcv:0000750
name: cold sensitive gain of function allele
namespace: allele_class
def: "An allele that at low temperatures but not high temperatures, either makes a normally functioning gene product but at higher levels or in a different spatial or temporal pattern to wild-type, or a product with increased or novel activity compared to wild-type." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000748 ! temperature conditional gain of function allele
relationship: conditionality FBcv:0000312 ! cold sensitive

[Term]
id: FBcv:0000751
name: temperature conditional hypomorphic allele
namespace: allele_class
def: "An allele that, at some temperatures but not others, makes a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000690 ! hypomorphic allele
is_a: FBcv:0000745 ! temperature conditional loss of function allele

[Term]
id: FBcv:0000752
name: heat sensitive hypomorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is functionally equivalent to wild-type but which at high temperatures is present in a lesser amount or with lowered activity, and that retains normal levels of expression or activity at low temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000746 ! heat sensitive loss of function allele
is_a: FBcv:0000751 ! temperature conditional hypomorphic allele

[Term]
id: FBcv:0000753
name: cold sensitive hypomorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is functionally equivalent to wild-type but which at low temperatures is present in a lesser amount or with lowered activity, and that retains normal function at higher temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000747 ! cold sensitive loss of function allele
is_a: FBcv:0000751 ! temperature conditional hypomorphic allele

[Term]
id: FBcv:0000754
name: temperature conditional hypomorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to have normal activity at some temperatures (permissive temperatures) but at other temperatures to make a gene product with normal function but in a lesser amount or with lowered activity (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy))." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000289 ! hypomorphic allele - genetic evidence
is_a: FBcv:0000751 ! temperature conditional hypomorphic allele

[Term]
id: FBcv:0000755
name: cold sensitive hypomorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to have normal activity at high temperatures (permissive temperatures) but to make a gene product with normal function but in a lesser amount or with lowered activity at lower temperatures (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy))." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000753 ! cold sensitive hypomorphic allele
is_a: FBcv:0000754 ! temperature conditional hypomorphic allele - genetic evidence

[Term]
id: FBcv:0000756
name: heat sensitive hypomorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to have normal activity at low temperatures (permissive temperatures) but to make a gene product with normal function but in a lesser amount or with lowered activity at higher temperatures (non-permissive temperatures). The genetic evidence must consist of an observation extra copies in the genome decrease the expressivity and/or penetrance of the phenotype at non-permissive temperatures. Most commonly this evidence takes the form of experiments showing that the homozygote (2 copies) has a weaker phenotype at non-permissive temperatures than the allele in trans to a deletion of the gene (1 copy))." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000752 ! heat sensitive hypomorphic allele
is_a: FBcv:0000754 ! temperature conditional hypomorphic allele - genetic evidence

[Term]
id: FBcv:0000757
name: temperature conditional hypomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a normal gene product in normal amounts at some temperatures, but at other temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000691 ! hypomorphic allele - molecular evidence
is_a: FBcv:0000751 ! temperature conditional hypomorphic allele

[Term]
id: FBcv:0000758
name: cold sensitive hypomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a normal gene product in normal amounts at high temperatures, but at lower temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000753 ! cold sensitive hypomorphic allele
is_a: FBcv:0000757 ! temperature conditional hypomorphic allele - molecular evidence

[Term]
id: FBcv:0000759
name: heat sensitive hypomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a normal gene product in normal amounts at low temperatures, but at higher temperatures to make a gene product that is functionally equivalent to wild-type but in a lesser amount or with lowered activity." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000752 ! heat sensitive hypomorphic allele
is_a: FBcv:0000757 ! temperature conditional hypomorphic allele - molecular evidence

[Term]
id: FBcv:0000760
name: temperature conditional antimorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at some temperatures, but not others." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000695 ! antimorphic allele
is_a: FBcv:0000748 ! temperature conditional gain of function allele

[Term]
id: FBcv:0000761
name: heat sensitive antimorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at high temperatures, but not at lower temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000749 ! heat sensitive gain of function allele
is_a: FBcv:0000760 ! temperature conditional antimorphic allele

[Term]
id: FBcv:0000762
name: cold sensitive antimorphic allele
namespace: allele_class
def: "An allele that makes a gene product that is antagonistic to the function of the wild-type gene product at cold temperatures, but not at higher temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000750 ! cold sensitive gain of function allele
is_a: FBcv:0000760 ! temperature conditional antimorphic allele

[Term]
id: FBcv:0000763
name: temperature conditional antimorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to make a gene product that is antagonistic to the wild-type gene product at some temperatures (restrictive temperatures) but not at others (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000292 ! antimorphic allele - genetic evidence
is_a: FBcv:0000760 ! temperature conditional antimorphic allele

[Term]
id: FBcv:0000764
name: cold sensitive antimorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to make a gene product that is antagonistic to the wild-type gene product at low temperatures (restrictive temperatures) but not at high temperatures (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000762 ! cold sensitive antimorphic allele
is_a: FBcv:0000763 ! temperature conditional antimorphic allele - genetic evidence

[Term]
id: FBcv:0000765
name: heat sensitive antimorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred to make a gene product that is antagonistic to the wild-type gene product at high temperatures (restrictive temperatures) but not at lower temperatures (permissive temperatures) from the observation that, at the non-permissive temperatures, the phenotype over a deficiency is stronger than that over a wild-type allele, which in turn is stronger than that in the presence of a duplication of the wild-type locus." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000761 ! heat sensitive antimorphic allele
is_a: FBcv:0000763 ! temperature conditional antimorphic allele - genetic evidence

[Term]
id: FBcv:0000766
name: temperature conditional antimorphic allele - molecular evidence
namespace: allele_class
def: "An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at some temperatures but not others." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000694 ! antimorphic allele - molecular evidence
is_a: FBcv:0000760 ! temperature conditional antimorphic allele

[Term]
id: FBcv:0000767
name: cold sensitive antimorphic allele - molecular evidence
namespace: allele_class
def: "An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at low temperatures but not higher temperatures." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000762 ! cold sensitive antimorphic allele
is_a: FBcv:0000766 ! temperature conditional antimorphic allele - molecular evidence

[Term]
id: FBcv:0000768
name: heat sensitive antimorphic allele - molecular evidence
namespace: allele_class
def: "An allele that has been shown by molecular evidence to make a gene product that is antagonistic to the function of the wild-type gene product at high temperatures but not lower temperatures." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000761 ! heat sensitive antimorphic allele
is_a: FBcv:0000766 ! temperature conditional antimorphic allele - molecular evidence

[Term]
id: FBcv:0000769
name: temperature conditional neomorphic allele
namespace: allele_class
def: "An allele that, at some temperatures but not others, makes a gene product with a novel function or expression pattern compared to wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000697 ! neomorphic allele
is_a: FBcv:0000748 ! temperature conditional gain of function allele

[Term]
id: FBcv:0000770
name: heat sensitive neomorphic allele
namespace: allele_class
def: "An allele that, at some high temperatures but not lower temperatures, makes a gene product with a novel function or expression pattern compared to wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000749 ! heat sensitive gain of function allele
is_a: FBcv:0000769 ! temperature conditional neomorphic allele

[Term]
id: FBcv:0000771
name: cold sensitive neomorphic allele
namespace: allele_class
def: "An allele that, at some low temperatures but not higher temperatures, makes a gene product at with a novel function or expression pattern compared to wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000750 ! cold sensitive gain of function allele
is_a: FBcv:0000769 ! temperature conditional neomorphic allele

[Term]
id: FBcv:0000772
name: temperature conditional neomorphic allele - genetic evidence
namespace: allele_class
def: "An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some temperatures (non-permissive temperatures) but not others (permissive temperatures) based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000291 ! neomorphic allele - genetic evidence
is_a: FBcv:0000769 ! temperature conditional neomorphic allele

[Term]
id: FBcv:0000773
name: cold sensitive neomorphic allele - genetic evidence
namespace: allele_class
def: "An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some low temperatures (non-permissive temperatures) but not higher temperatures (permissive temperatures), based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000771 ! cold sensitive neomorphic allele
is_a: FBcv:0000772 ! temperature conditional neomorphic allele - genetic evidence

[Term]
id: FBcv:0000774
name: heat sensitive neomorphic allele - genetic evidence
namespace: allele_class
def: "An allele that, is inferred to make a gene product with a novel function or expression pattern compared to wild-type at some high temperatures (non-permissive temperatures) but not lower temperatures (permissive temperatures), based on the evidence that the phenotype at the non-permissive temperature is unaffected by extra or fewer doses of the wild-type gene." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000770 ! heat sensitive neomorphic allele
is_a: FBcv:0000772 ! temperature conditional neomorphic allele - genetic evidence

[Term]
id: FBcv:0000775
name: temperature conditional neomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at some temperatures but not others." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000692 ! neomorphic allele - molecular evidence
is_a: FBcv:0000769 ! temperature conditional neomorphic allele

[Term]
id: FBcv:0000776
name: cold sensitive neomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at low temperatures but not higher temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000771 ! cold sensitive neomorphic allele
is_a: FBcv:0000775 ! temperature conditional neomorphic allele - molecular evidence

[Term]
id: FBcv:0000777
name: heat sensitive neomorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to produce a gene product with a novel function or expression pattern (compared to wild-type) at high temperatures but not lower temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000770 ! heat sensitive neomorphic allele
is_a: FBcv:0000775 ! temperature conditional neomorphic allele - molecular evidence

[Term]
id: FBcv:0000778
name: temperature conditional hypermorphic allele
namespace: allele_class
def: "An allele that, at some temperatures but not others, makes a gene product with normal function but at higher levels or with higher activity than in wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000696 ! hypermorphic allele
is_a: FBcv:0000748 ! temperature conditional gain of function allele

[Term]
id: FBcv:0000779
name: heat sensitive hypermorphic allele
namespace: allele_class
def: "An allele that, at high temperatures but not lower temperatures, makes a gene product with normal function but at higher levels or with higher activity than in wild-type." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000749 ! heat sensitive gain of function allele
is_a: FBcv:0000778 ! temperature conditional hypermorphic allele

[Term]
id: FBcv:0000780
name: cold sensitive hypermorphic allele
namespace: allele_class
def: "An allele that, at low temperatures but not higher temperatures, makes a gene product with normal function but at higher levels or with higher activity than in wild-type.." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000750 ! cold sensitive gain of function allele
is_a: FBcv:0000778 ! temperature conditional hypermorphic allele

[Term]
id: FBcv:0000781
name: temperature conditional hypermorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at some temperatures (non-permissive temperatures) but not others (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000293 ! hypermorphic allele - genetic evidence
is_a: FBcv:0000778 ! temperature conditional hypermorphic allele

[Term]
id: FBcv:0000782
name: cold sensitive hypermorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at low temperatures (non-permissive temperatures) but not higher temperatures (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000780 ! cold sensitive hypermorphic allele
is_a: FBcv:0000781 ! temperature conditional hypermorphic allele - genetic evidence

[Term]
id: FBcv:0000783
name: heat sensitive hypermorphic allele - genetic evidence
namespace: allele_class
def: "An allele inferred from genetic evidence to make a normal gene product at increased levels or with increased activity compared to wild-type, where this increased amount or activity is present at high temperatures (non-permissive temperatures) but not lower temperatures (permissive temperatures), and where the genetic evidence consists of the observation that extra copies in the genome increase the expressivity and/or penetrance of the phenotype at the non-permissive temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000779 ! heat sensitive hypermorphic allele
is_a: FBcv:0000781 ! temperature conditional hypermorphic allele - genetic evidence

[Term]
id: FBcv:0000784
name: temperature conditional hypermorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at some temperatures but not others." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000693 ! hypermorphic allele - molecular evidence
is_a: FBcv:0000778 ! temperature conditional hypermorphic allele

[Term]
id: FBcv:0000785
name: cold sensitive hypermorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at low temperatures but not higher temperatures." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000780 ! cold sensitive hypermorphic allele
is_a: FBcv:0000784 ! temperature conditional hypermorphic allele - molecular evidence

[Term]
id: FBcv:0000786
name: heat sensitive hypermorphic allele - molecular evidence
namespace: allele_class
def: "An allele shown by molecular evidence to make a functionally wild-type gene product at increased levels or with increased activity where this increased expression or activity occurs at high temperatures but not lower temperatures." [FBC:DOS, FlyBase:FBrf0049147]
is_a: FBcv:0000779 ! heat sensitive hypermorphic allele
is_a: FBcv:0000784 ! temperature conditional hypermorphic allele - molecular evidence

[Term]
id: FBcv:0000787
name: journal
namespace: pub_type
def: "A publication issued on a regular, ongoing basis containing separate research articles and other writings such as reviews, comments and conference reports." [FBC:SM, MeSH:D020492]
synonym: "Periodicals" RELATED [MeSH:D020492]
xref: MeSH:D020492
is_a: FBcv:0000652 ! compendium

[Term]
id: FBcv:0000788
name: newspaper article
namespace: pub_type
def: "A work consisting of a news item appearing in a general-interest newspaper or other general news periodical, containing information of current and timely interest in the field of medicine or science." [FBC:SM, MeSH:D018431]
xref: MeSH:D018431
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000789
name: sequence record
namespace: pub_type
def: "A record of a nucleotide or protein sequence in some standard format." [FBC:SM]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000790
name: database
namespace: pub_type
def: "Work consisting of a structured file of information or a set of logically related data stored and retrieved using computer-based means." [FBC:SM, MeSH:D019991]
xref: MeSH:D019991
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0000791
name: decreased speed of aging
namespace: phenotypic_class
def: "A phenotype in which the aging process is slower than in wild-type." [FBC:DOC]
synonym: "delayed aging" RELATED []
synonym: "reduced speed of aging" EXACT []
is_a: FBcv:0000384 ! abnormal aging

[Term]
id: FBcv:0000792
name: increased speed of aging
namespace: phenotypic_class
def: "A phenotype in which the aging process is accelerated compared to wild-type." [FBC:DOC]
synonym: "premature aging" RELATED []
is_a: FBcv:0000384 ! abnormal aging

[Term]
id: FBcv:0000793
name: progressive
namespace: temporal_qualifier
def: "A phenotype that becomes more severe with age." [FBC:DOS]
is_a: FBcv:0000176 ! temporal qualifier

[Term]
id: FBcv:0000797
name: cell autonomy qualifier
namespace: genotype_to_phenotype_relation
def: "Cell autonomy statements describe the cellular focus of mutant phenotype, generally revealed by genetic mosaic analysis, in terms of whether the mutant has its phenotypic effect limited to, or not limited to, cells of the mutant genotype." [FBC:rd]
subset: do_not_annotate
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000799
name: obsolete gene descriptor
is_obsolete: true

[Term]
id: FBcv:0000801
name: obsolete polymorphism assay
is_obsolete: true

[Term]
id: FBcv:0000803
name: obsolete RFLP
synonym: "restriction fragment length polymorphism" RELATED []
is_obsolete: true

[Term]
id: FBcv:0000805
name: obsolete DNA sequence variant
is_obsolete: true

[Term]
id: FBcv:0000807
name: allele descriptor
def: "Descriptor that relates to aspects of an allele." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0000809
name: phenotype qualifier
def: "Qualifier that describes an observable phenotype." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0000811
name: qualitative qualifier
def: "Qualifier that describes a particular quality of an observable phenotype." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000812
name: clone of cells
namespace: clone_qualifier
def: "A clone of cells that share a genotype." [FBC:DOS]
synonym: "clone qualifier" RELATED []
is_a: FBcv:0000809 ! phenotype qualifier

[Term]
id: FBcv:0000813
name: nitrogen mustard
namespace: origin_of_mutation
def: "Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR (from CHEBI)." [CHEBI:37598]
synonym: "2-chloro-N-(2-chloroethyl)-N-methylethanamine" RELATED []
synonym: "CB1414" RELATED []
synonym: "HN2" RELATED []
synonym: "mechlorethamine" RELATED []
synonym: "mutation induced by nitrogen mustard exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000814
name: 1,4-dimethanesulfonoxybutane
namespace: origin_of_mutation
def: "A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant (from CHEBI)." [CHEBI:28901]
synonym: "busulfan" RELATED [CHEBI:28901]
synonym: "CB2041" RELATED []
synonym: "mutation induced by 1,4-dimethanesulfonoxybutane exposure" EXACT []
synonym: "mutation induced by busulfan exposure" EXACT []
is_a: FBcv:0000526 ! alkylating agent

[Term]
id: FBcv:0000815
name: p-N,N-di-(2-chloroethyl)aminophenylbutyric acid
namespace: origin_of_mutation
def: "A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia (from CHEBI)." [CHEBI:28830]
synonym: "CB1348" RELATED []
synonym: "chlorambucil" EXACT [CHEBI:28830]
synonym: "mutation induced by chlorambucil exposure" EXACT []
synonym: "mutation induced by p-N,N-di-(2-chloroethyl)aminophenylbutyric acid exposure" EXACT []
is_a: FBcv:0000813 ! nitrogen mustard

[Term]
id: FBcv:0001003
name: cold sensitive amorphic allele
def: "An allele that completely lacks function (i.e. whose gene productive is completely inactive) at low temperatures, but that retains at least some function at higher temperatures." [FBC:DOS, FlyBase:FBrf0002371, FlyBase:FBrf0049147]
is_a: FBcv:0000739 ! temperature conditional amorphic allele
is_a: FBcv:0000747 ! cold sensitive loss of function allele

[Term]
id: FBcv:0001315
name: beta-estradiol conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence of beta-estradiol (CHEBI:16469)." [FBC:DOS]
synonym: "conditional beta-estradiol" EXACT []
is_a: FBcv:0000313 ! drug conditional

[Term]
id: FBcv:0001324
name: obsolete endocytosis defective
namespace: phenotypic_class
def: "Phenotype that is a defect in endocytosis (GO:0006897). 'endocytosis' is defined as: 'A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.'" [FBC:DOS]
comment: Obsoleted as this is phenotype is too molecular to be captured by FlyBase phenotype curation and will be captured by GO curation [FBC:CP].
synonym: "abnormal endocytosis" EXACT []
is_obsolete: true

[Term]
id: FBcv:0001325
name: obsolete exocytosis defective
namespace: phenotypic_class
def: "Phenotype that is a defect in exocytosis (GO:0006887). 'exocytosis' is defined as: 'A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.'" []
comment: Obsoleted as this is phenotype is too molecular to be captured by FlyBase phenotype curation and will be captured by GO curation [FBC:CP].
synonym: "abnormal exocytosis" EXACT []
is_obsolete: true

[Term]
id: FBcv:0001347
name: phenotype
namespace: phenotypic_class
def: "Any abnormality in or loss of some anatomical structure or biological process compared to wild-type." [FBC:DOS]
comment: The subclasses of this term classify Drosophila phenotypes into different common categories. They have been chosen by FlyBase to reflect phenotype terms most often reported by Drosophila researchers in the published literature.
subset: do_not_annotate
synonym: "phenotypic class" EXACT []
is_a: FBcv:0000347 ! phenotypic class

[Term]
id: FBcv:0001500
name: minos activity
namespace: origin_of_mutation
def: "Mutation induced by the transposable activity caused by Minos, a DNA transposable element. The minos element is 1.4 kilobases in length with 254 base pairs inverted terminal repeats. It specifically targets TA dinucleotides and generates a flanking duplication of 2 base pairs upon insertion. Mobilization is induced by the activity of the minos transposase." [FBC:DOS, FlyBase:FBrf0202435]
synonym: "mutation induced by minos activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0002000
name: lethal - all die before end of P-stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages prior to eclosion from the pupal case (the end of the P-stage)." [FBC:DOS]
comment: As the P-Stage and the 'pharate adult stage' have the same end, there is no need for a separate term for 'lethal - all die before end of pharate adult stage.
subset: lethal_phase
synonym: "lethal - all die before end of pharate adult stage" EXACT []
synonym: "pupal lethal" BROAD []
is_a: FBcv:0000351 ! lethal

[Term]
id: FBcv:0002001
name: lethal - all die before end of first instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the first instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002003 ! lethal - all die before end of second instar larval stage

[Term]
id: FBcv:0002002
name: lethal - all die before end of larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the larval stage." [FBC:DOS]
comment: As the larval stage and third instar larval stage have the same end, there is no need for a separate term for 'lethal - all die before end of third instar larval stage'.
subset: lethal_phase
synonym: "larval lethal" BROAD []
synonym: "lethal - all die before end of third instar larval stage" EXACT []
is_a: FBcv:0002026 ! lethal - all die before end of prepupal stage

[Term]
id: FBcv:0002003
name: lethal - all die before end of second instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the second instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002002 ! lethal - all die before end of larval stage

[Term]
id: FBcv:0002004
name: increased mortality
namespace: phenotypic_class
def: "A phenotype that is an increase in the rate of death in a population at any stage of life (during development or adulthood), over the rate seen in a wild type control population." [FBC:DOS]
subset: fbcvsubset_mgiribbons
subset: lethal_phase
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0002005
name: lethal - all die during P-stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the P-stage." [FBC:DOS]
subset: lethal_phase
synonym: "pupal lethal" BROAD []
is_a: FBcv:0002000 ! lethal - all die before end of P-stage
is_a: FBcv:0002010 ! majority die during P-stage

[Term]
id: FBcv:0002006
name: lethal - all die during first instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the first instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002001 ! lethal - all die before end of first instar larval stage
is_a: FBcv:0002007 ! lethal - all die during larval stage
is_a: FBcv:0002011 ! majority die during first instar larval stage

[Term]
id: FBcv:0002007
name: lethal - all die during larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the larval stage." [FBC:DOS]
subset: lethal_phase
synonym: "larval lethal" BROAD []
is_a: FBcv:0002002 ! lethal - all die before end of larval stage
is_a: FBcv:0002012 ! majority die during larval stage

[Term]
id: FBcv:0002008
name: lethal - all die during second instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the second instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002003 ! lethal - all die before end of second instar larval stage
is_a: FBcv:0002007 ! lethal - all die during larval stage
is_a: FBcv:0002013 ! majority die during second instar larval stage

[Term]
id: FBcv:0002009
name: lethal - all die during third instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the third instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002007 ! lethal - all die during larval stage
is_a: FBcv:0002014 ! majority die during third instar larval stage

[Term]
id: FBcv:0002010
name: majority die during P-stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the P-stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002020 ! some die during P-stage

[Term]
id: FBcv:0002011
name: majority die during first instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the first instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002012 ! majority die during larval stage
is_a: FBcv:0002021 ! some die during first instar larval stage

[Term]
id: FBcv:0002012
name: majority die during larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002023 ! some die during larval stage

[Term]
id: FBcv:0002013
name: majority die during second instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the second instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002012 ! majority die during larval stage
is_a: FBcv:0002022 ! some die during second instar larval stage

[Term]
id: FBcv:0002014
name: majority die during third instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the third instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002012 ! majority die during larval stage
is_a: FBcv:0002024 ! some die during third instar larval stage

[Term]
id: FBcv:0002015
name: partially lethal
namespace: phenotypic_class
def: "A phenotype of a population that is the death of some significant proportion of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS, FBC:KM]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0002019
name: increased mortality during development
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population prior to becoming a mature adult, where mature is defined as after adult stage A3 (FBdv:00006012)." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002004 ! increased mortality

[Term]
id: FBcv:0002020
name: some die during P-stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the P-stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0002021
name: some die during first instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the first instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002023 ! some die during larval stage

[Term]
id: FBcv:0002022
name: some die during second instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the second instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002023 ! some die during larval stage

[Term]
id: FBcv:0002023
name: some die during larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0002024
name: some die during third instar larval stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the third instar larval stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002023 ! some die during larval stage

[Term]
id: FBcv:0002025
name: lethal - all die during pharate adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the pharate adult stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002005 ! lethal - all die during P-stage
is_a: FBcv:0002036 ! majority die during pharate adult stage

[Term]
id: FBcv:0002026
name: lethal - all die before end of prepupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the prepupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002027 ! lethal - all die before end of pupal stage

[Term]
id: FBcv:0002027
name: lethal - all die before end of pupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the pupal stage." [FBC:DOS]
subset: lethal_phase
synonym: "pupal lethal" BROAD []
is_a: FBcv:0002000 ! lethal - all die before end of P-stage

[Term]
id: FBcv:0002030
name: lethal - all die during pupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the pupal stage." [FBC:DOS]
subset: lethal_phase
synonym: "pupal lethal" BROAD []
is_a: FBcv:0002005 ! lethal - all die during P-stage
is_a: FBcv:0002027 ! lethal - all die before end of pupal stage
is_a: FBcv:0002034 ! majority die during pupal stage

[Term]
id: FBcv:0002031
name: lethal - all die during prepupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the prepupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002005 ! lethal - all die during P-stage
is_a: FBcv:0002026 ! lethal - all die before end of prepupal stage
is_a: FBcv:0002035 ! majority die during prepupal stage

[Term]
id: FBcv:0002032
name: obsolete lethal - all die before end of embryonic stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population at some stage or stages before the end of the embryonic stage." [FBC:DOS]
comment: Obsoleted due to equivalence with FBcv:0002033 'lethal - all die during embryonic stage'.
is_obsolete: true
replaced_by: FBcv:0002033

[Term]
id: FBcv:0002033
name: lethal - all die during embryonic stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population during the embryonic stage." [FBC:DOS]
subset: lethal_phase
synonym: "embryonic lethal" EXACT []
is_a: FBcv:0002001 ! lethal - all die before end of first instar larval stage
is_a: FBcv:0002037 ! majority die during embryonic stage

[Term]
id: FBcv:0002034
name: majority die during pupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the pupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002010 ! majority die during P-stage
is_a: FBcv:0002039 ! some die during pupal stage

[Term]
id: FBcv:0002035
name: majority die during prepupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the prepupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002010 ! majority die during P-stage
is_a: FBcv:0002040 ! some die during prepupal stage

[Term]
id: FBcv:0002036
name: majority die during pharate adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the pharate adult stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002010 ! majority die during P-stage
is_a: FBcv:0002038 ! some die during pharate adult stage

[Term]
id: FBcv:0002037
name: majority die during embryonic stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population during the embryonic stage." [FBC:DOS]
comment: This term is agnostic about whether any survive to adulthood.
subset: lethal_phase
is_a: FBcv:0002041 ! some die during embryonic stage

[Term]
id: FBcv:0002038
name: some die during pharate adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the pharate adult stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002020 ! some die during P-stage

[Term]
id: FBcv:0002039
name: some die during pupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the pupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002020 ! some die during P-stage

[Term]
id: FBcv:0002040
name: some die during prepupal stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the prepupal stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002020 ! some die during P-stage

[Term]
id: FBcv:0002041
name: some die during embryonic stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of a significant proportion of animals in that population during the embryonic stage." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0002042
name: lethal - all die during immature adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of all animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012))." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0000351 ! lethal
is_a: FBcv:0002050 ! majority die during immature adult stage

[Term]
id: FBcv:0002050
name: majority die during immature adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of the majority of animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012))." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002051 ! some die during immature adult stage

[Term]
id: FBcv:0002051
name: some die during immature adult stage
namespace: phenotypic_class
def: "A phenotype of a population that is the death of some significant number of animals in that population as immature adults (after eclosion but before the end of adult stage A3 (FBdv:00006012))." [FBC:DOS]
subset: lethal_phase
is_a: FBcv:0002019 ! increased mortality during development

[Term]
id: FBcv:0003000
name: disease qualifier
namespace: disease_qualifier
def: "Qualifier that describes aspects of genetic models of disease." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000005 ! qualifier

[Term]
id: FBcv:0003001
name: ameliorates
namespace: disease_qualifier
def: "Makes a condition better." [FBC:ST]
comment: The 'ameliorates' term is used in FlyBase disease annotation when an allele interacts to remove or reduce the severity of the disease phenotype associated with a given disease model (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier

[Term]
id: FBcv:0003002
name: DOES NOT ameliorate
namespace: disease_qualifier
def: "Contrary to expectation, does not make a condition better." [FBC:ST]
comment: The 'DOES NOT ameliorate' term is used in FlyBase disease annotation when an allele is expected to remove or reduce the severity of the disease phenotype associated with a given disease model but fails to do so.
is_a: FBcv:0003000 ! disease qualifier

[Term]
id: FBcv:0003003
name: DOES NOT exacerbate
namespace: disease_qualifier
def: "Contrary to expectation, does not make a condition worse." [FBC:ST]
comment: The 'DOES NOT exacerbate' term is used in FlyBase disease annotation when an allele is expected to makes the disease phenotype associated with a given disease model more severe but fails to do so (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier

[Term]
id: FBcv:0003004
name: DOES NOT model
namespace: disease_qualifier
def: "Contrary to expectation, characteristics associated with a given condition are not recapitulated in a different system." [FBC:ST]
comment: The 'DOES NOT model' term is used in FlyBase disease annotation when an allele is expected to recapitulate one or more aspects of a particular human disease phenotype in Drosophila but fails to do so (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier

[Term]
id: FBcv:0003005
name: exacerbates
namespace: disease_qualifier
def: "Makes a condition worse." [FBC:ST]
comment: The 'exacerbates' term is used in FlyBase disease annotation when an allele interacts to make the disease phenotype associated with a given disease model more severe (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier

[Term]
id: FBcv:0003006
name: model of
namespace: disease_qualifier
def: "Characteristics associated with a given condition recapitulated in a different system." [FBC:ST]
comment: The 'model of' term is used in FlyBase disease annotation when alleles (typically of fly or human genes) recapitulate one or more aspect of a human disease phenotype in Drosophila (FBC:ST).
is_a: FBcv:0003000 ! disease qualifier

[Term]
id: FBcv:0003007
name: site specific cleavage
namespace: origin_of_mutation
def: "Sequence change induced by a cleavage event that is caused by an endonuclease that recognizes and cleaves specific sequences in double stranded DNA causing double-strand breaks (DSB)." [FlyBase:FBrf0202435]
synonym: "change induced by site specific cleavage" EXACT []
is_a: FBcv:0000452 ! origin of mutation

[Term]
id: FBcv:0003008
name: CRISPR/Cas9
namespace: origin_of_mutation
def: "Sequence change caused by a cleavage of a specific DNA sequence induced by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 nuclease system. This system relies on the transcription of a chimeric guide RNA (gRNA) which directs the Cas9 endonuclease to a specified DNA sequence through basepairing to 20 nucleotide CRISPR target sites. These sites are located next to a 3 nucleotide protospacer adjacent motif (PAM) required for DNA cleavage." [FlyBase:FBrf0222128, FlyBase:FBrf0222292, FlyBase:FBrf0222617, UniProt:Q99ZW2]
synonym: "change induced by CRISPR/Cas9 endonuclease cleavage" EXACT []
synonym: "CRISPR/Cas9 endonuclease" RELATED []
is_a: FBcv:0003007 ! site specific cleavage

[Term]
id: FBcv:0003009
name: TALEN
namespace: origin_of_mutation
def: "Sequence change caused by the cleavage of specific DNA sequences by transcription activator-like effector nucleases (TALENs). TALEN proteins comprise a DNA binding domain fused to the catalytic domain of the FokI endonuclease. The DNA binding domain contains a repetitive region within the middle of the protein, consisting of tandem repeats of 34 amino acid segments, with each of these segments recognizing a single base pair. The specificity of the binding is determined by two hypervariable amino acids in positions 12 and 13 (repeat-variable diresidues). Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of TALENs which bind to adjacent sequences separated by a spacer region, allowing dimerization and promoting cleavage." [PMID:10954606, PMID:20660643]
synonym: "change induced by TALE endonuclease cleavage" EXACT []
synonym: "TALE endonuclease" RELATED []
is_a: FBcv:0003007 ! site specific cleavage

[Term]
id: FBcv:0003010
name: phiC31 integrase
namespace: origin_of_mutation
def: "Sequence change caused by a site specific recombination catalyzed by the serine recombinase phiC31 integrase that recognizes a minimal high-efficiency attP recognition site of 39 base pairs and a minimal high-efficiency attB recognition site of 34 base pairs. The attP and attB sites contain imperfect inverted repeats flanking a short recombination core (TTG) that provides directionality." [FlyBase:FBrf0174693, FlyBase:FBrf0201927, UniProt:Q9T221]
synonym: "change induced by phiC31 integrase recombination" EXACT []
is_a: FBcv:0000478 ! site specific recombination

[Term]
id: FBcv:0003011
name: group descriptor
namespace: group_descriptor
def: "Descriptor that relates aspects of the grouping of genes or gene products." [FBC:MMC]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0003012
name: gene or gene product group
namespace: group_descriptor
def: "Genes or gene products that are acknowledged to form a natural biological group." [FBC:SM]
is_a: FBcv:0003011 ! group descriptor

[Term]
id: FBcv:0003013
name: gene array group
namespace: group_descriptor
def: "Two or more genes contiguously arranged where the individual genes are either identical in sequence, or essentially so (SO:0005851)." [FBC:SM, SO:ma]
is_a: FBcv:0003012 ! gene or gene product group

[Term]
id: FBcv:0003014
name: functional group
namespace: group_descriptor
def: "Genes whose products share a common biological and/or molecular function." [FBC:SM]
is_a: FBcv:0003012 ! gene or gene product group

[Term]
id: FBcv:0003015
name: gene complex group
namespace: group_descriptor
def: "Genes with the same location on the chromosome and whose products have a similar function." [FBC:SM, http://www.sdbonline.org/fly/aignfam/ensplitc.htm]
is_a: FBcv:0003014 ! functional group

[Term]
id: FBcv:0003016
name: protein complex group
namespace: group_descriptor
def: "Genes whose protein products form a macromolecular complex (GO:0043234)." [FBC:SM, GOC:go_curators]
is_a: FBcv:0003014 ! functional group

[Term]
id: FBcv:0003017
name: pathway group
namespace: group_descriptor
def: "Genes whose products act in a specified signal transduction or metabolic pathway." [FBC:SM]
is_a: FBcv:0003014 ! functional group

[Term]
id: FBcv:0003018
name: process group
namespace: group_descriptor
def: "Genes whose products act in a specified biological process." [FBC:SM]
is_a: FBcv:0003014 ! functional group

[Term]
id: FBcv:0003019
name: I-element activity
namespace: origin_of_mutation
def: "Mutation caused by the transposable activity caused by the I-element, a non-LTR retrotransposon. The I-element is 5371 base pairs long. Mobilization is induced by the activity of the I-element transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by I-element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0003020
name: Stalker element activity
namespace: origin_of_mutation
def: "Mutation caused by the transposable activity caused by the Stalker element, a LTR retrotransposon. Mobilization is induced by the activity of the stalker element transposase." [FlyBase:FBrf0202435]
synonym: "mutation induced by Stalker element activity" EXACT []
is_a: FBcv:0000483 ! transposable element activity

[Term]
id: FBcv:0003021
name: dataset descriptor
def: "Term that describes a dataset." [FBC:GD]
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0003022
name: dataset entity type
namespace: dataset_entity_type
def: "Term that specifies the dataset component type." [FBC:GD]
is_a: FBcv:0003021 ! dataset descriptor

[Term]
id: FBcv:0003023
name: project
namespace: dataset_entity_type
def: "A set of biological data from a single study. Corresponds to the NCBI bioproject, GEO series or SRA study." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type

[Term]
id: FBcv:0003024
name: biosample
namespace: dataset_entity_type
def: "Biological source material characterized by an experiment." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type

[Term]
id: FBcv:0003025
name: assay
namespace: dataset_entity_type
def: "Quantitative or qualitative assessment of biological source material to measure some attribute." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type

[Term]
id: FBcv:0003026
name: result
namespace: dataset_entity_type
def: "Analysis of raw data generated by an assay(s) that makes some conclusion." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type

[Term]
id: FBcv:0003027
name: reagent collection
namespace: dataset_entity_type
def: "A collection of material reagents." [FBC:GD]
is_a: FBcv:0003022 ! dataset entity type

[Term]
id: FBcv:0003028
name: dataset data type
def: "The data type content of a dataset." [FBC:GD]
is_a: FBcv:0003021 ! dataset descriptor

[Term]
id: FBcv:0003029
name: project type
namespace: project_type
def: "The type of project as characterized its data content." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type

[Term]
id: FBcv:0003030
name: umbrella project
namespace: project_type
def: "A project that groups together related sub-projects." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003031
name: genome
namespace: project_type
def: "A project that characterizes an organism's genome sequence." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003032
name: genome variation
namespace: project_type
def: "A project that characterizes the intraspecific variation of an organism's genome." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003033
name: genome binding
namespace: project_type
def: "A project that characterizes the occupancy profile of a factor that binds directly or indirectly to the genome." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003034
name: transcriptome
namespace: project_type
def: "A project that characterizes the set of transcribed RNA sequences expressed by the genome." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003035
name: proteome
namespace: project_type
def: "A project that characterizes the set of proteins expressed in an organism." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003036
name: interactome
namespace: project_type
def: "A project that characterizes the set of inter-molecular interactions in an organism." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003037
name: metabolome
namespace: project_type
def: "A project that characterizes the set of small molecules in an organism." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003038
name: phenotypic screen
namespace: project_type
def: "A project that searches for the genes responsible for a particular observable trait." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003039
name: chemical screen
namespace: project_type
def: "A project that searches for chemicals, natural or synthetic, that elicit some biological effect." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003040
name: gene model annotation
namespace: project_type
def: "A project that constructs models describing the set of transcripts and polypeptides encoded by some group of genes." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003041
name: phylogenetic analysis
namespace: project_type
def: "A project that reconstructs the evolutionary history of a group of genes or organisms." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003042
name: reagent
namespace: project_type
def: "A project that describes a large material resource that is accessible to the community." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003043
name: other
namespace: project_type
def: "A project type that is not described by other more specific terms." [FBC:GD]
is_a: FBcv:0003029 ! project type

[Term]
id: FBcv:0003044
name: biosample type
namespace: biosample_type
def: "The type of biosample as characterized by its biological source material." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type

[Term]
id: FBcv:0003045
name: whole organism
namespace: biosample_type
def: "A biosample that comprises the whole animal." [FBC:GD]
is_a: FBcv:0003044 ! biosample type

[Term]
id: FBcv:0003046
name: tissue
namespace: biosample_type
def: "A biosample derived from a multicellular structure comprising similar cells with some specific function, typically isolated by dissection." [FBC:GD]
is_a: FBcv:0003044 ! biosample type

[Term]
id: FBcv:0003047
name: isolated cells
namespace: biosample_type
def: "A biosample containing dissociated cells isolated from the organism, typically isolated by affinity capture or sorting methods." [FBC:GD]
is_a: FBcv:0003044 ! biosample type

[Term]
id: FBcv:0003048
name: primary cell line
namespace: biosample_type
def: "A biosample consisting of cells that were isolated from animal tissue and cultured in vitro for a limited amount of time." [FBC:GD]
is_a: FBcv:0003044 ! biosample type

[Term]
id: FBcv:0003049
name: immortalized cell line
namespace: biosample_type
def: "A biosample consisting of cells isolated from animal tissue that have acquired the ability to proliferate indefinitely." [FBC:GD]
is_a: FBcv:0003044 ! biosample type

[Term]
id: FBcv:0003050
name: assay type
namespace: assay_type
def: "The type of assay as characterized by its data content." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type

[Term]
id: FBcv:0003051
name: CAGE-Seq
namespace: assay_type
def: "An assay of 5' capped transcripts, using CAGE to biotinylate and isolate the 7-methylguanosine cap, with subsequent characterization by high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003052
name: ChIP-chip
namespace: assay_type
def: "A genome binding assay of some factor as characterized by chromatin immunoprecipitation (ChIP) of that factor and analysis of co-purifying DNA fragments using genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003053
name: ChIP-Seq
namespace: assay_type
def: "A genome binding assay of some factor as characterized by chromatin immunoprecipitation (ChIP) of that factor and high-throughput sequencing of co-purifying DNA fragments." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003054
name: CLiP-Seq
namespace: assay_type
def: "An RNA binding assay of some protein as characterized by cross-linking immunoprecipitation (CLiP) and high-throughput sequencing of co-purifying RNA fragments." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003055
name: DamID-chip
namespace: assay_type
def: "A genome binding assay of some protein as characterized by creating a fusion to DNA adenine methyltransferase and analysis of methylated DNA sequences by genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003056
name: DamID-Seq
namespace: assay_type
def: "A genome binding assay of some protein as characterized by creating a fusion to DNA adenine methyltransferase and analysis of methylated DNA sequences by high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003057
name: DNase-chip
namespace: assay_type
def: "An assay that characterizes the genome's DNase hypersensitivity using genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003058
name: DNase-Seq
namespace: assay_type
def: "An assay that characterizes the genome's DNase hypersensitivity using high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003059
name: FAIRE-Seq
namespace: assay_type
def: "An assay that characterizes transcriptional regulatory elements using formaldehyde-assisted isolation of regulatory elements (FAIRE) and high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003060
name: GRO-Seq
namespace: assay_type
def: "An assay that maps the genome-wide position, orientation and amount of transcriptionally engaged RNA polymerase by global run-on sequencing." [PMID:19056941]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003061
name: MNase-chip
namespace: assay_type
def: "An assay that maps nucleosome positions by using micrococcal nuclease to cleave linker DNA with the subsequent isolation of mononucleosomal DNA fragments that are characterized by genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003062
name: MNase-Seq
namespace: assay_type
def: "An assay that maps nucleosome positions by using micrococcal nuclease to cleave linker DNA with the subsequent isolation of mononucleosomal DNA fragments that are characterized by high-throughput sequencing." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003063
name: RAMPAGE-Seq
namespace: assay_type
def: "An assay of 5'-capped transcripts using the orthogonal approaches of reverse transcriptase template-switching and cap-trapping, with subsequent characterization by high-throughput sequencing." [PMID:22936248]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003064
name: Repli-Seq
namespace: assay_type
def: "An assay mapping genomic replication patterns by labeling newly synthesized DNA in vivo with 5-bromo-2-deoxyuridine (BrdU), with subsequent affinity purification and characterization by high-throughput sequencing." [PMID:19966280]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003065
name: Ribo-Seq
namespace: assay_type
def: "Ribosome profiling, an assay in which mRNA fragments protected by ribosomes are isolated and characterized by high-throughput sequencing." [PMID:22056041]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003066
name: RIP-Seq
namespace: assay_type
def: "An assay in which a factor is immunoprecipitated and the associated RNA sequences are characterized by high-throughput sequencing." [PMID:21051541]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003067
name: RNA expression microarray
namespace: assay_type
def: "Measurement of global transcript abundance by hybridization of cDNA to an oligonucleotide array, in which the array contains a set of probes designed with complementarity to each annotated transcript." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003068
name: RNA-Seq
namespace: assay_type
def: "A quantitative method for mapping transcribed regions, in which complementary DNA fragments are subjected to high-throughput sequencing." [PMID:18451266]
xref: EFO:0008896
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003069
name: RNA tiling array
namespace: assay_type
def: "Measurement of transcribed regions across the genome by hybridization of cDNA to an oligonucleotide array, in which the genome is represented by oligonucleotides at regularly spaced intervals." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003070
name: short RNA-Seq
namespace: assay_type
def: "An assay characterizing of small RNA species 17-35 nt in size by high-throughput sequencing." [FBC:GD]
xref: EFO:0008947
is_a: FBcv:0003068 ! RNA-Seq

[Term]
id: FBcv:0003071
name: protein mass spectrometry
namespace: assay_type
def: "An assay that identifies and characterizes of proteins and their post-translational modifications by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003072
name: lipid mass spectrometry
namespace: assay_type
def: "An assay that identifies and characterizes lipids by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003073
name: carbohydrate mass spectrometry
namespace: assay_type
def: "An assay that identifies and characterizes complex carbohydrates by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003074
name: metabolite mass spectrometry
namespace: assay_type
def: "An assay that identifies and characterizes small metabolites by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003075
name: affinity purification and mass spectrometry
namespace: assay_type
def: "An assay that identifies the molecules that interact with a particular bait factor by mass spectrometry." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003076
name: two hybrid screen
namespace: assay_type
def: "An assay that tests proteins pairwise for interaction by fusing each to separate, complementary domains of some protein, usually a transcription factor. Upon interaction, the proximity of the complementary domains generates reporter activity." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003077
name: RNAi screen
namespace: assay_type
def: "An assay that uses a panel of RNA interference (RNAi) reagents to systematically knockdown a large set of genes, one at a time, to identify those that are involved in some biological process." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003078
name: deficiency screen
namespace: assay_type
def: "An assay that uses a panel of deficiencies to systematically delete large segments of the genome to identify those segments that are involved in some biological process." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003079
name: genetic screen
namespace: assay_type
def: "An assay that uses a large set of mutations to identify genes that are involved in some biological process." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003080
name: comparative genomic hybridization by array
namespace: assay_type
def: "An assay that characterizes copy number variation of the genome in a sample using genome tiling array." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003081
name: whole genome shotgun sequencing
namespace: assay_type
def: "An assay of genomic sequence that generates a large number of random genomic sequences, typically derived from paired-end sequencing of genomic fragments, that together give a complete (albeit scrambled) representation of the entire genome." [FBC:GD]
is_a: FBcv:0003050 ! assay type

[Term]
id: FBcv:0003082
name: result type
namespace: result_type
def: "The type of result as characterized by its data content." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type

[Term]
id: FBcv:0003083
name: genetic map
namespace: result_type
def: "A result that maps the relative position of genetic markers, where distances are measured by recombination frequency." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003084
name: physical map
namespace: result_type
def: "A result that maps the relative position of genes and other sequence landmarks." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003085
name: whole genome shotgun assembly
namespace: result_type
def: "A result in which a collection of whole genome shotgun sequences is combined to build successively larger contigs." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003086
name: genome assembly
namespace: result_type
def: "The result of reconstruction of the genome achieved by aligning and merging smaller fragments." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003087
name: reference genome assembly
namespace: result_type
def: "The result of extensive sequence alignment and merging to produce a genome assembly that serves as the current reference for a particular organism." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003088
name: gene expression profile
namespace: result_type
def: "A result that provides the expression values for all (or some subset) of genes in a given biological sample." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003089
name: RNA-seq profile
namespace: result_type
def: "A result that profiles expressed RNA-seq sequences along genome." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003090
name: genome binding profile
namespace: result_type
def: "A result that profiles the genome occupancy for some factor." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003091
name: mRNA translation profile
namespace: result_type
def: "A result of Ribo-seq analysis that profiles ribosome protected sequences along the genome." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003092
name: TSS identification
namespace: result_type
def: "An analysis that results in the identification of discrete transcription start site regions." [FBC:GD]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0003093
name: poly(A) site identification
namespace: result_type
def: "An analysis that results in the identification of discrete polyadenylation sites." [FBC:GD]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0003094
name: exon junction identification
namespace: result_type
def: "An analysis that results in the identification of discrete exon junctions." [FBC:GD]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0003095
name: editing site identification
namespace: result_type
def: "An analysis that results in the identification of discrete A-to-I RNA editing sites." [FBC:GD]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0003096
name: binding site identification
namespace: result_type
def: "An analysis that results in the identification of discrete DNA or RNA binding sites." [FBC:GD]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0003097
name: differential gene expression analysis
namespace: result_type
def: "An analysis that results from the comparison of expression profiles for different conditions to identify genes that are regulated by those conditions." [FBC:GD]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0003098
name: expression clustering
namespace: result_type
def: "The analysis of a gene expression profiles to define sets of genes that share similar expression characteristics." [FBC:GD]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0003099
name: expression cluster
namespace: result_type
def: "A result that represents a set of genes that share similar expression characteristics across some set of conditions." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003100
name: gene list
namespace: result_type
def: "A result that represents a set of genes that have some shared characteristic." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003101
name: protein-protein interaction
namespace: result_type
def: "A result that represents a set of protein-protein interactions for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003102
name: RNA-protein interaction
namespace: result_type
def: "A result that represents a set of RNA-protein interactions for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003103
name: RNA-RNA interaction
namespace: result_type
def: "A result that represents a set of RNA-RNA interactions for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003104
name: metabolite profile
namespace: result_type
def: "A result that represents a set of small molecules identified for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003105
name: phenotypic profile
namespace: result_type
def: "A result that represents the range of phenotypes obtained for a set of genetic perturbations." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003106
name: genomic copy number profile
namespace: result_type
def: "A result that represents the copy number variation across the genome for a given sample." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003107
name: liftover file
namespace: result_type
def: "A result that represents the mapping of coordinates between two different genome assemblies for a given species." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003108
name: analysis
namespace: result_type
def: "A result that is produced from the detailed examination of data to come to some conclusion." [FBC:GD]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0003109
name: reagent collection type
namespace: reagent_collection_type
def: "The type of reagent collection as characterized by the material resources comprised by the collection." [FBC:GD]
is_a: FBcv:0003028 ! dataset data type

[Term]
id: FBcv:0003110
name: aberration stock collection
namespace: reagent_collection_type
def: "A collection of large chromosomal aberrations, available as fly stocks, which may include duplications, deletions, inversions or translocations." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003111
name: allele collection
namespace: reagent_collection_type
def: "A collection of alleles that are available as fly stocks." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003112
name: cDNA library
namespace: reagent_collection_type
def: "A collection of cDNAs available as plasmids." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003113
name: construct collection
namespace: reagent_collection_type
def: "A collection of transgenic constructs that are available as fly stocks." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003114
name: dsRNA amplicon collection
namespace: reagent_collection_type
def: "A collection of PCR products used for the synthesis of double-stranded RNA to induce RNA-interference." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003115
name: RNAi construct collection
namespace: reagent_collection_type
def: "A collection of transgenic constructs, available as fly stocks, designed to target gene knockdown by RNA-interference." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003116
name: genomic clone collection
namespace: reagent_collection_type
def: "A collection of genomic DNA clones available as plasmids. This may include BAC, YAC, fosmid, cosmid and P1 clone collections." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003117
name: fly strain collection
namespace: reagent_collection_type
def: "A collection of wild-type fly strains." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003118
name: transgenic insertion collection
namespace: reagent_collection_type
def: "A collection of transgenic construct insertions available as fly stocks." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003119
name: TE insertion stock collection
namespace: reagent_collection_type
def: "A collection of transposable element insertions available as fly stocks." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003120
name: microarray library
namespace: reagent_collection_type
def: "A collection of hybridization targets on a microarray." [FBC:GD]
is_a: FBcv:0003109 ! reagent collection type

[Term]
id: FBcv:0003121
name: dataset attribute
def: "A descriptor that describes some aspect of a dataset." [FBC:GD]
is_a: FBcv:0003021 ! dataset descriptor

[Term]
id: FBcv:0003122
name: project attribute
namespace: project_attribute
def: "A descriptor that describes some aspect of a project." [FBC:GD]
is_a: FBcv:0003121 ! dataset attribute

[Term]
id: FBcv:0003123
name: study design
namespace: project_attribute
def: "The aim of the project investigation, as defined by the key variables in the set of experiments." [FBC:GD]
is_a: FBcv:0003122 ! project attribute

[Term]
id: FBcv:0003124
name: species study
namespace: project_attribute
def: "A project study design that aims to compare different species." [FBC:GD]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003125
name: strain study
namespace: project_attribute
def: "A project study design that aims to compare different wild-type strains for a given species." [FBC:GD]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003126
name: sex study
namespace: project_attribute
def: "A project study design that aims to characterize the biological mechanisms responsible for the development or maintenance of the sex-related properties of an organism." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003127
name: developmental stage study
namespace: project_attribute
def: "A project study design investigating the biological mechanisms responsible for the control or maintenance of development." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003128
name: circadian rhythm study
namespace: project_attribute
def: "A project study design investigating the biological mechanisms responsible for the control or maintenance of circadian rhythm." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003129
name: cell cycle study
namespace: project_attribute
def: "A project study design investigating the biological mechanisms of the cell responsible for maintaining or controlling aspects of the cell cycle." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003130
name: tissue type study
namespace: project_attribute
def: "A project study design investigating the biological mechanisms of intact or dissected tissues in order to understand their form or function." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003131
name: cell type study
namespace: project_attribute
def: "A project study design involving the use of cultured or extracted cells with an investigative focus of studying a cellular property." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003132
name: subcellular component study
namespace: project_attribute
def: "A project study design examining subcellular components of cells including organelles, the nucleus, or any other grouping of intra- or extracellular material." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003133
name: gene study
namespace: project_attribute
def: "A project study design in which the goal of the study is to examine properties of a specific gene or set of genes." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003134
name: biotic stimulus study
namespace: project_attribute
def: "A project study design investigating the effects of a biotic stimulus on some aspect of an organism." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003135
name: chemical stimulus study
namespace: project_attribute
def: "A project study design investigating the effects of a chemical stimulus on some aspect of an organism." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003136
name: physical stimulus study
namespace: project_attribute
def: "A project study design investigating the effects of a physical stimulus on some aspect of an organism." [FBC:CT]
is_a: FBcv:0003123 ! study design

[Term]
id: FBcv:0003137
name: biosample attribute
namespace: biosample_attribute
def: "Characteristics pertaining to the growth conditions, treatments and tissue isolation methods used to generate and obtain a biosample." [FBC:GD]
is_a: FBcv:0003121 ! dataset attribute

[Term]
id: FBcv:0003138
name: biosample scope
namespace: biosample_attribute
def: "The scope and purity of a biosample, ranging from single cell to environmental sample." [http://www.ncbi.nlm.nih.gov/books/NBK54364/]
is_a: FBcv:0003137 ! biosample attribute

[Term]
id: FBcv:0003139
name: single cell sample
namespace: biosample_attribute
def: "A biosample that is derived from only a single cell." [FBC:CT]
is_a: FBcv:0003138 ! biosample scope

[Term]
id: FBcv:0003140
name: single individual sample
namespace: biosample_attribute
def: "A biosample that is derived from one individual." [FBC:CT]
is_a: FBcv:0003138 ! biosample scope

[Term]
id: FBcv:0003141
name: multi-individual sample
namespace: biosample_attribute
def: "A biosample that is derived from multiple individuals." [FBC:CT]
is_a: FBcv:0003138 ! biosample scope

[Term]
id: FBcv:0003142
name: multispecies sample
namespace: biosample_attribute
def: "A biosample that is derived from multiple species." [FBC:CT]
is_a: FBcv:0003138 ! biosample scope

[Term]
id: FBcv:0003143
name: environmental
namespace: biosample_attribute
def: "A biosample derived from an environmental sample for which the species content is unknown." [http://www.ncbi.nlm.nih.gov/books/NBK54364/]
is_a: FBcv:0003138 ! biosample scope

[Term]
id: FBcv:0003144
name: artificial
namespace: biosample_attribute
def: "A biosample that was synthesized in a laboratory." [http://www.ncbi.nlm.nih.gov/books/NBK54364/]
is_a: FBcv:0003138 ! biosample scope

[Term]
id: FBcv:0003145
name: wild caught
namespace: biosample_attribute
def: "A sample that originated from a wild caught population and is considered true wild type." [FBC:CT]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003146
name: growth condition
namespace: biosample_attribute
def: "Growth conditions and treatments used to culture the organism prior to biosample isolation." [FBC:GD]
is_a: FBcv:0003137 ! biosample attribute

[Term]
id: FBcv:0003147
name: trait selection
namespace: biosample_attribute
def: "An inbred strain is subjected to artificial laboratory selection of some trait over the course of several generations." [FBC:GD]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003148
name: interspecific hybrid
namespace: biosample_attribute
def: "A sample that is derived from a controlled mating between individuals of two specific species." [FBC:CT]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003149
name: mated
namespace: biosample_attribute
def: "A sample in which the individuals have undergone mating." [FBC:CT]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003150
name: virgin
namespace: biosample_attribute
def: "A sample in which the individuals have not undergone mating." [FBC:CT]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003151
name: constant dark
namespace: biosample_attribute
def: "A sample that is maintained in conditions comparable to constant darkness." [FBC:CT]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003152
name: constant light
namespace: biosample_attribute
def: "A sample that is maintained in conditions comparable to constant light." [FBC:CT]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003153
name: light-dark cycle
namespace: biosample_attribute
def: "A sample that is maintained in conditions with a specific cycle that included exposure to both light and darkness." [FBC:CT]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003154
name: primary cell culture
namespace: biosample_attribute
def: "A sample that is derived from a primary cell culture." [FBC:CT]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0003155
name: cell culture property
namespace: biosample_attribute
def: "Characteristics pertaining to the cell culture conditions used to generate the biosample." [FBC:GD]
is_a: FBcv:0003137 ! biosample attribute

[Term]
id: FBcv:0003156
name: transiently transfected cell line
namespace: biosample_attribute
def: "A sample that contains a transfected agent which is not incorporated into the genome." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property

[Term]
id: FBcv:0003157
name: stably transfected cell line
namespace: biosample_attribute
def: "A sample that contains a transfected agent which has been stably incorporated into the genome." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property

[Term]
id: FBcv:0003158
name: log phase cells
namespace: biosample_attribute
def: "A sample that is derived from a population of cells undergoing a log phase of division." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property

[Term]
id: FBcv:0003159
name: stationary phase cells
namespace: biosample_attribute
def: "A sample that is derived from a population of cells undergoing a stationary phase of division." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property

[Term]
id: FBcv:0003160
name: cell cycle synchronized cells
namespace: biosample_attribute
def: "A sample that is derived from a population of cells undergoing cell cycle division in a synchronized manner." [FBC:CT]
is_a: FBcv:0003155 ! cell culture property

[Term]
id: FBcv:0003161
name: suspension culture
namespace: biosample_attribute
def: "The cells that are grown in liquid culture." [FBC:GD]
is_a: FBcv:0003155 ! cell culture property

[Term]
id: FBcv:0003162
name: adherent culture
namespace: biosample_attribute
def: "The cells that are grown on plates." [FBC:GD]
is_a: FBcv:0003155 ! cell culture property

[Term]
id: FBcv:0003163
name: culture supernatant
namespace: biosample_attribute
def: "The conditioned medium containing factors secreted by cultured cells that has been isolated." [FBC:GD]
is_a: FBcv:0003155 ! cell culture property

[Term]
id: FBcv:0003164
name: biosample method
namespace: biosample_attribute
def: "Methods pertaining to the experimental treatment or isolation of a biosample." [FBC:GD]
is_a: FBcv:0003137 ! biosample attribute

[Term]
id: FBcv:0003165
name: gene perturbation
namespace: biosample_attribute
def: "A sample that has undergone a disruption to the activity of one of its genes." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method

[Term]
id: FBcv:0003166
name: biotic treatment
namespace: biosample_attribute
def: "Treatment of an organism with a biological stimulus, such as an infectious or parasitic agent." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method

[Term]
id: FBcv:0003167
name: chemical treatment
namespace: biosample_attribute
def: "A sample that has been exposed to one or more forms of chemical agent." [FBC:CT]
is_a: FBcv:0009014 ! biosample treatment method

[Term]
id: FBcv:0003168
name: physical treatment
namespace: biosample_attribute
def: "A sample that has been exposed to changes in the physical environment including temperature, pressure and radiation." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method

[Term]
id: FBcv:0003169
name: tissue dissection
namespace: biosample_attribute
def: "A sample that has been dissected from the tissue of a more complete organism." [FBC:CT]
is_a: FBcv:0009015 ! biosample preparation method

[Term]
id: FBcv:0003170
name: cell isolation
namespace: biosample_attribute
def: "A single cell type that has been isolated by affinity purification or fluorescent cell sorting." [FBC:GD]
is_a: FBcv:0009015 ! biosample preparation method

[Term]
id: FBcv:0003171
name: subcellular fractionation
namespace: biosample_attribute
def: "A sample that has undergone fractionation in order to isolate specific subcellular components for study." [FBC:CT]
is_a: FBcv:0009015 ! biosample preparation method

[Term]
id: FBcv:0003172
name: cell ablation
namespace: biosample_attribute
def: "A sample in which specific cells within a tissue have been ablated by some method, such as targeted expression of a cell toxin, or laser ablation of fluorescently marked cells." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method

[Term]
id: FBcv:0003173
name: targeted cell labeling
namespace: biosample_attribute
def: "A sample that has been labelled in a targeted, cell-specific manner." [FBC:CT]
is_a: FBcv:0009014 ! biosample treatment method

[Term]
id: FBcv:0003174
name: neuronal activity perturbation
namespace: biosample_attribute
def: "Neuronal activity that has been perturbed using genetically controlled agents to activate or depress membrane potential." [FBC:GD]
is_a: FBcv:0009014 ! biosample treatment method

[Term]
id: FBcv:0003175
name: assay attribute
namespace: assay_attribute
def: "Some characteristic of an assay pertaining to the methods involved in processing the biological source material or generating the raw output data of the assay." [FBC:GD]
is_a: FBcv:0003121 ! dataset attribute

[Term]
id: FBcv:0003176
name: assay material
namespace: assay_attribute
def: "A type of biomolecule that is isolated from a biosample and characterized by downstream steps in an assay." [FBC:GD]
is_a: FBcv:0003175 ! assay attribute

[Term]
id: FBcv:0003177
name: genomic DNA isolation
namespace: assay_attribute
def: "Material that is derived from isolation of genomic DNA." [FBC:CT]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003178
name: total RNA isolation
namespace: assay_attribute
def: "Material that is derived from isolation of the total RNA." [FBC:CT]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003179
name: poly(A) RNA isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of RNA containing a poly(A) tail." [FBC:CT]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003180
name: short RNA isolation
namespace: assay_attribute
def: "The isolation of small RNA species 17-35 nt in size." [FBC:GD]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003181
name: translated mRNA isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of translated messenger RNA." [FBC:CT]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003182
name: protein isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of proteins." [FBC:CT]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003183
name: chromatin isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of chromatin and its subcellular components and/or binding partners." [FBC:CT]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003184
name: RNA-protein isolation
namespace: assay_attribute
def: "Isolation of RNA-protein complexes." [FBC:GD]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003185
name: metabolite isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of metabolites." [FBC:CT]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0003186
name: assay material depletion
namespace: assay_attribute
def: "The biosample that is depleted of specific biomolecule types before further processing." [FBC:GD]
is_a: FBcv:0003175 ! assay attribute

[Term]
id: FBcv:0003187
name: rRNA depletion
namespace: assay_attribute
def: "Material that has undergone the depletion of ribosomal RNA." [FBC:CT]
is_a: FBcv:0003186 ! assay material depletion

[Term]
id: FBcv:0003188
name: ssRNA depletion
namespace: assay_attribute
def: "Material that has undergone the depletion of single-stranded RNA." [FBC:CT]
is_a: FBcv:0003186 ! assay material depletion

[Term]
id: FBcv:0003189
name: dsRNA depletion
namespace: assay_attribute
def: "Material that has undergone the depletion of double-stranded RNA." [FBC:CT]
is_a: FBcv:0003186 ! assay material depletion

[Term]
id: FBcv:0003190
name: unbound RNA depletion
namespace: assay_attribute
def: "Material that has undergone the depletion of unbound RNA." [FBC:CT]
is_a: FBcv:0003186 ! assay material depletion

[Term]
id: FBcv:0003191
name: assay material selection
namespace: assay_attribute
def: "The biosample that is enriched for a specific biomolecule type for further processing." [FBC:GD]
is_a: FBcv:0003175 ! assay attribute

[Term]
id: FBcv:0003192
name: ChIP
namespace: assay_attribute
def: "Material that has been selected using Chromatin Immunoprecipitation, or ChIP." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003193
name: DamID
namespace: assay_attribute
def: "Material that has been selected using DNA Adenine Methyltransferase Identification, or DamID." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003194
name: FAIRE
namespace: assay_attribute
def: "Material that has been selected using formaldehyde-assisted isolation of Regulatory Elements or FAIRE." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003195
name: CAGE
namespace: assay_attribute
def: "Material that has been selected using Cap Analysis Gene Expression, in which the 7-methylguanosine cap at 5' transcript ends is biotinylated and affinity purified." [PMID:16489339]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003196
name: MNase
namespace: assay_attribute
def: "Chromatin that has been cleaved using micrococcal nuclease to cleave at linker DNA between nucleosomes." [FBC:GD]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003197
name: DNase
namespace: assay_attribute
def: "Material that has been selected from a sample treated by deoxyribonuclease." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003198
name: low salt chromatin extraction
namespace: assay_attribute
def: "Material that has been selected using a low salt chromatin extraction, typically 80mM." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003199
name: high salt chromatin extraction
namespace: assay_attribute
def: "Material that has been selected using a high salt chromatin extraction, typically 600mM." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003200
name: mononucleosomal DNA isolation
namespace: assay_attribute
def: "Mononucleosomal fragments, generated by micrococcal nuclease cleavage at linker DNA between nucleosomes, that have been isolated by gel electrophoresis." [FBC:GD]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003201
name: affinity purification
namespace: assay_attribute
def: "Material that has been selected using affinity purification." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003202
name: size fractionation
namespace: assay_attribute
def: "Material that has been selected using size fractionation." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003203
name: oligo-dT selection
namespace: assay_attribute
def: "Material that has been selected using short sequences of deoxy-thymine nucleotides to affinity purify RNA containing long polyA stretches." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003204
name: oligo-dT priming
namespace: assay_attribute
def: "Material that has been selected using short sequences of deoxy-thymine nucleotides to prime first strand cDNA synthesis by reverse transcriptase at long polyA stretches." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003205
name: random priming
namespace: assay_attribute
def: "Random oligomers that have been used to prime first strand cDNA synthesis by reverse transcriptase at random positions along transcripts." [FBC:GD]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003206
name: density sedimentation
namespace: assay_attribute
def: "Material that has been selected based on density via density sedimentation." [FBC:CT]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003207
name: nuclear run-on
namespace: assay_attribute
def: "Nucleotide analogs that are used to map the position and orientation of the RNA polymerase active site." [FBC:GD]
is_a: FBcv:0003191 ! assay material selection

[Term]
id: FBcv:0003208
name: assay method
namespace: assay_attribute
def: "A method used to characterize the biological molecules isolated from a biosample." [FBC:GD]
is_a: FBcv:0003175 ! assay attribute

[Term]
id: FBcv:0003209
name: Sanger sequencing
namespace: assay_attribute
def: "A method that uses Sanger sequencing for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003210
name: single molecule real time sequencing
namespace: assay_attribute
def: "A method that uses single molecule sequencing, by highly processive DNA polymerase to generate an extremely long single read on the order of several kilobases, for this assay." [FBC:GD]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003211
name: high-throughput sequencing
namespace: assay_attribute
def: "A method that uses high-throughput sequencing for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003212
name: 454 sequencing
namespace: assay_attribute
def: "A method that uses 454 sequencing, a form of high-throughput sequencing with 400-500 nt read length, for this assay." [FBC:CT]
is_a: FBcv:0003211 ! high-throughput sequencing

[Term]
id: FBcv:0003213
name: Illumina sequencing
namespace: assay_attribute
def: "A method that uses Illumina sequencing, a form of high-throughput sequencing, for this assay." [FBC:CT]
is_a: FBcv:0003211 ! high-throughput sequencing

[Term]
id: FBcv:0003214
name: Affymetrix Gene Expression Array 1
namespace: assay_attribute
def: "A method that uses an Affymetrix Gene Expression Array, version 1, for this assay." [FBC:CT, FBC:GD]
is_a: FBcv:0003240 ! expression array

[Term]
id: FBcv:0003215
name: Affymetrix Gene Expression Array 2
namespace: assay_attribute
def: "A method that uses an Affymetrix Gene Expression Array, version 2, for this assay." [FBC:CT]
is_a: FBcv:0003240 ! expression array

[Term]
id: FBcv:0003216
name: genomic tiling array
namespace: assay_attribute
def: "A method that uses a genomic tiling array, a subtype of microarray chip in which the genome is represented by oligonucleotides at regularly spaced intervals, for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003217
name: peptide array
namespace: assay_attribute
def: "A method that uses a peptide array, a subtype of microarray chip, for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003218
name: mass spectrometry
namespace: assay_attribute
def: "A method that uses mass spectrometry, an analytical technique for sorting ions based on mass, for this assay." [FBC:CT]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003219
name: two channel scanning
namespace: assay_attribute
def: "A method that uses two samples, one a control and the other an experimental sample, for this assay. The samples are labeled in different colors and hybridized to the same oligonucleotide array. Each sample is scanned using different excitation and emission parameters." [FBC:GD]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003220
name: single-end layout
namespace: assay_attribute
def: "A method that uses an RNA-seq assay in which only one end of the library fragment is sequenced." [FBC:GD]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003221
name: paired-end layout
namespace: assay_attribute
def: "A method that uses an RNA-seq assay in which both ends of the library fragment are sequenced to provide additional mapping constraints." [FBC:GD]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0003222
name: result attribute
namespace: result_attribute
def: "Some characteristic of a result pertaining to the methods involved in analyzing the input data, or the content or format of the output data." [FBC:GD]
is_a: FBcv:0003121 ! dataset attribute

[Term]
id: FBcv:0003223
name: stranded profile
namespace: result_attribute
def: "A genomic mapping profile that distinguishes forward and reverse strand distributions." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003224
name: unstranded profile
namespace: result_attribute
def: "A genomic mapping profile that does not distinguish between forward and reverse strand mapping." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003225
name: uniquely mapping read alignment
namespace: result_attribute
def: "An alignment of high-throughput sequences that includes only those reads mapping uniquely to the genome." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003226
name: multiply mapping read alignment
namespace: result_attribute
def: "An alignment of high-throughput sequences that includes reads mapping to multiple sites in the genome. Coverage values for a given sequence weighted equally across the multiple sites to which it maps." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003227
name: RPKM calculation
namespace: result_attribute
def: "A unit of expression (reads per kilobase per million reads) in which high-throughput sequencing reads mapping to a given feature are normalized both to the size of that feature and to the total number of reads in the sample." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003228
name: RPMM calculation
namespace: result_attribute
def: "A unit of expression (reads per million miRNA reads) in which high-throughput sequencing reads for a given miRNA are normalized against all reads mapping to all miRNA." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003229
name: RPM calculation
namespace: result_attribute
def: "A unit of expression (reads per million reads) in which high-throughput sequencing reads for a given type of feature are normalized against all reads mapping to all features of the same type." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003230
name: clone-based finishing
namespace: result_attribute
def: "Sequencing the full extent of selected large clones, typically by sub-cloning large inserts as smaller fragments, to improve the accuracy and completeness of an assembly." [FlyBase:FBrf0155823]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003231
name: restriction fingerprinting
namespace: result_attribute
def: "Mapping of restriction enzyme recognition sites to develop a physical map of a genome." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003232
name: sequence tagged site mapping
namespace: result_attribute
def: "Mapping of short (200-500 bp) sequence-tagged sites (STS) landmarks to develop a physical map of a genome." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003233
name: tiling path
namespace: result_attribute
def: "An ordered list of a minimal set of overlapping clones that provides complete coverage across an assembly." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003234
name: cytogenetic mapping
namespace: result_attribute
def: "Sequences that have been mapped to mitotic or polytene chromosomes to guide genome assembly." [FBC:GD]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003235
name: assembly level - chromosome
namespace: result_attribute
def: "There is sequence for one or more chromosomes. This could be a completely sequenced chromosome without gaps or a chromosome containing scaffolds or contigs with gaps between them. There may also be unplaced or unlocalized scaffolds." [http://www.ncbi.nlm.nih.gov/assembly/help/]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003236
name: assembly level - scaffold
namespace: result_attribute
def: "Some sequence contigs have been connected across gaps to create scaffolds, but no scaffolds have been placed on chromosomes." [http://www.ncbi.nlm.nih.gov/assembly/help/]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003237
name: genome representation - full
namespace: result_attribute
def: "The assembly represents the whole genome, though there may still be gaps." [http://www.ncbi.nlm.nih.gov/assembly/help/]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003238
name: genome representation - partial
namespace: result_attribute
def: "The assembly represents only part of the organism's genome, because only a single chromosome was targeted, coverage is <1, or total length is less than half the average for other assemblies of the same species." [http://www.ncbi.nlm.nih.gov/assembly/help/]
is_a: FBcv:0003222 ! result attribute

[Term]
id: FBcv:0003239
name: ZFN
namespace: origin_of_mutation
def: "Sequence change caused by the cleavage of specific DNA sequences by zinc finger nucleases (ZFNs). ZFN proteins comprise a DNA binding domain linked to the DNA cleavage domain of FokI endonuclease. The DNA binding domain is composed of three Cys2His2 zinc fingers, with each zinc finger contacting three consecutive base pairs of DNA. The specificity of the binding is determined by the sequence of the three-zinc finger DNA binding domain, which recognizes a 9 base pair sequence. Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of ZFNs which bind to sequences in close proximity, allowing dimerization and promoting cleavage." [PMID:10954606, PMID:12730594, PMID:8577732]
subset: camcur
synonym: "change induced by zinc finger nuclease-mediated cleavage" EXACT []
synonym: "zinc finger nuclease" RELATED []
is_a: FBcv:0003007 ! site specific cleavage

[Term]
id: FBcv:0003240
name: expression array
namespace: assay_attribute
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0004000
name: abnormal visual perception
namespace: phenotypic_class
def: "Phenotype that is any abnormality in sensory perception of light stimulus (GO:0050953). 'sensory perception of light stimulus' is defined as: 'The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.'" [FBC:MMC, GOC:ai]
synonym: "visual perception defective" EXACT []
is_a: FBcv:0000681 ! abnormal sensory perception

[Term]
id: FBcv:0005000
name: Bxb1 integrase
namespace: origin_of_mutation
def: "Sequence change caused by a site specific recombination catalyzed by the serine recombinase Bxb1 integrase that recognizes a minimal high-efficiency attPX recognition site of 48 base pairs and a minimal high-efficiency attBX recognition site of 38 base pairs. The attPX and attBX sites share an 8bp common core flanked by imperfect inverted repeats (19bp in attPX and 8bp in attBX). A non-palindromic central dinucleotide (5'-GT) determines the directionality of integration." [PMID:14636570]
synonym: "change induced by Bxb1 integrase recombination" EXACT []
is_a: FBcv:0000478 ! site specific recombination

[Term]
id: FBcv:0005001
name: experimental tool descriptor
def: "Term that describes the use of an experimental tool." [FBC:GM]
subset: do_not_annotate
is_a: FBcv:0000013 ! descriptor

[Term]
id: FBcv:0005002
name: gene product detection tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that gene product by an experimental method." [FBC:GM]
synonym: "gene product detection tag" RELATED [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005003
name: RNA detection tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the RNA product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that RNA product by an experimental method." [FBC:GM]
synonym: "RNA detection tag" RELATED [FBC:TJ]
is_a: FBcv:0005002 ! gene product detection tool

[Term]
id: FBcv:0005004
name: protein detection tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of that protein product by an experimental method." [FBC:GM]
synonym: "protein detection tag" RELATED [FBC:TJ]
is_a: FBcv:0005002 ! gene product detection tool

[Term]
id: FBcv:0005005
name: reporter enzyme
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity can be used to detect the presence of that protein product." [FBC:GM]
subset: common_tool_use
xref: MI:0365
is_a: FBcv:0005004 ! protein detection tool

[Term]
id: FBcv:0005006
name: fluorescent protein
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that exhibits the property of fluorescence, that can be used to detect the presence of that protein product. A fluorescent protein emits light following the absorption of radiation, with the wavelength of the emitted light being longer than the excitation wavelength of the absorbed radiation." [FBC:GM]
subset: common_tool_use
xref: MI:0687
is_a: FBcv:0005004 ! protein detection tool

[Term]
id: FBcv:0005007
name: green fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 499-519nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005008
name: blue fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 424-467nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005009
name: cyan fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 474-492nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
xref: MI:0733
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005010
name: yellow fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 524-538nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
xref: MI:0368
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005011
name: orange fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 559-572nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005012
name: red fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 574-610nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
xref: MI:0732
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005013
name: far-red fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak within the wavelength range of 625-659nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005014
name: infra-red fluorescent protein
namespace: experimental_tool_descriptor
def: "Protein having well characterized fluorescence excitation and emission spectra, with an emission peak equal or greater than 670nm." [FBC:GM, http://blog.addgene.org/which-fluorescent-protein-should-i-use]
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005015
name: modulatable fluorescent protein
namespace: experimental_tool_descriptor
def: "A fluorescent protein whose spectral properties are changeable, resulting from a reversible or irreversible change in fluorophore conformation. Changes in fluorophore conformation may occur either as a function of time (in the case of fluorescent timer proteins), or in response to an external trigger such as irradiation with a specific wavelength of light (in the case of photomodulatable fluorescent proteins)." [FBC:TEMJ]
is_a: FBcv:0005006 ! fluorescent protein

[Term]
id: FBcv:0005016
name: photomodulatable fluorescent protein
namespace: experimental_tool_descriptor
def: "A fluorescent protein whose spectral properties can be modulated by exposure to light of a specific wavelength, triggering a conformational change of the fluorophore and subsequent change in fluorescent state." [FBC:TEMJ, PMID:20539741]
is_a: FBcv:0005015 ! modulatable fluorescent protein

[Term]
id: FBcv:0005017
name: photoactivatable fluorescent protein
namespace: experimental_tool_descriptor
def: "A protein that can be switched from an essentially non-fluorescent state to a fluorescent state by irradiation with a pulse of light of a specific wavelength. This activation is irreversible." [FBC:GM, http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/]
is_a: FBcv:0005016 ! photomodulatable fluorescent protein

[Term]
id: FBcv:0005018
name: photoconvertible fluorescent protein
namespace: experimental_tool_descriptor
def: "A protein that can be converted from one fluorescent state to another fluorescent state (with a changed emission spectrum peak) by irradiation with a pulse of light of a specific wavelength. This conversion is irreversible." [FBC:GM, http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/]
is_a: FBcv:0005016 ! photomodulatable fluorescent protein

[Term]
id: FBcv:0005019
name: photoswitchable fluorescent protein
namespace: experimental_tool_descriptor
def: "A protein that can be reversibly switched between a non-fluorescent state and a fluorescent state, or between two different fluorescent states. The switch from one state to the other is triggered by irradiation with a pulse of light of a specific wavelength, and the switch back to the original state is triggered with a pulse of light of another specific wavelength." [FBC:GM, FBC:TEMJ, http://www.leica-microsystems.com/science-lab/photoactivatable-photoconvertable-and-photoswitchable-fluorescent-proteins/]
is_a: FBcv:0005016 ! photomodulatable fluorescent protein

[Term]
id: FBcv:0005020
name: fluorescent timer protein
namespace: experimental_tool_descriptor
def: "A protein that converts from one fluorescent state to another fluorescent state (with a changed emission spectrum peak) over time." [FBC:GM]
is_a: FBcv:0005015 ! modulatable fluorescent protein

[Term]
id: FBcv:0005021
name: epitope tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an epitope that can be used to detect the presence of the tagged protein product. An epitope (SO:0001018) is defined as 'A binding site that, in the molecule, interacts selectively and non-covalently with antibodies, B cells or T cells.'" [FBC:GM]
is_a: FBcv:0005004 ! protein detection tool
is_a: FBcv:0007029 ! specific binding tool

[Term]
id: FBcv:0005022
name: gene product localization tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged gene product either to a specific subcellular location within the cell or for secretion to the extracellular space." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005023
name: protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein either to a specific subcellular location within the cell or for secretion to the extracellular space." [FBC:GM, http://en.wikipedia.org/wiki/Target_peptide]
xref: SO:0001527
is_a: FBcv:0005022 ! gene product localization tag

[Term]
id: FBcv:0005024
name: nuclear protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the nucleus." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005025
name: mitochondrial protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the mitochondrion." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005026
name: peroxisomal protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the peroxisome." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005027
name: centrosome protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the centrosome." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005028
name: microtubule protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the microtubule." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005029
name: endoplasmic reticulum protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the endoplasmic reticulum." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005030
name: Golgi protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the Golgi apparatus." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005031
name: membrane protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to a cellular membrane. The membrane targeting sequence may be an intrinsic component of the membrane (GO:0031224), having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane; or may be an extrinsic component of the membrane (GO:0019898), being loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [FBC:GM, GOC:dos, GOC:jl, GOC:mah]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005032
name: plasma membrane protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the plasma membrane." [FBC:GM]
is_a: FBcv:0005031 ! membrane protein localization tag

[Term]
id: FBcv:0005033
name: vesicle protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to a vesicle." [FBC:GM]
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005034
name: signal sequence
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the secretory pathway. This results in the protein either being secreted or inserted into a cellular membrane, depending on the presence of other specific sequences in the tagged protein. The signal sequence must be fused to the N-terminal end of the tagged protein." [FBC:GM, http://en.wikipedia.org/wiki/Signal_peptide]
xref: SO:0000418
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005035
name: nuclear export signal
namespace: experimental_tool_descriptor
def: "A peptide sequence used to target a tagged protein for export from the nucleus to the cytoplasm." [FBC:GM, http://en.wikipedia.org/wiki/Nuclear_export_signal, SO:0001531]
synonym: "NES" EXACT []
xref: SO:0001531
is_a: FBcv:0005023 ! protein localization tag

[Term]
id: FBcv:0005036
name: purification tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific, novel property that facilitates purification of the gene product and/or any associated macromolecular complex by an experimental method." [FBC:GM]
synonym: "isolation tag" EXACT []
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005037
name: gene product activity regulation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which is used to regulate the activity of the tagged gene product." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005038
name: conditional activity regulation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the activity of the tagged gene product being regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0005037 ! gene product activity regulation tag

[Term]
id: FBcv:0005039
name: light-regulated activity regulation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the activity of the tagged gene product being regulated in response to irradiation with a pulse of light." [FBC:GM]
synonym: "light-dependent activity regulation tag" EXACT []
is_a: FBcv:0005038 ! conditional activity regulation tag

[Term]
id: FBcv:0005040
name: small molecule-regulated activity regulation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
synonym: "small molecule-dependent activity regulation tag" EXACT []
is_a: FBcv:0005038 ! conditional activity regulation tag

[Term]
id: FBcv:0005041
name: chromophore-assisted light inactivation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein encoded by a transgenic locus or modified endogenous locus and which allows a protein to be inactivated by the chromophore-assisted light inactivation (CALI) technique. The tag consists of a peptide sequence that specifically binds a membrane-permeable, chromophore-containing molecule. When activated using a pulse of high-intensity light that is absorbed by the chromophore but not by cellular components, the membrane-permeable molecule generates short-lived reactive oxygen species which inactivate the tagged protein to which the molecule is bound via the chromophore-assisted light inactivation tag." [FBC:GM, PMID:14625562, PMID:16605242, PMID:21226520, PMID:3399501]
synonym: "CALI tag" EXACT []
is_a: FBcv:0005039 ! light-regulated activity regulation tag

[Term]
id: FBcv:0005042
name: degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation." [FBC:GM]
synonym: "gene product degradation tag" EXACT []
is_a: FBcv:0007068 ! gene product degradation tool

[Term]
id: FBcv:0005043
name: cell cycle-regulated degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by the cell cycle." [FBC:GM]
synonym: "cell cycle-regulated gene product degradation tag" EXACT []
is_a: FBcv:0009016 ! conditional degradation tag

[Term]
id: FBcv:0005044
name: genetically encoded sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of a biologically relevant property that is not part of or directly encoded by the genome, for example pH, redox state, membrane potential, a change in concentration of a particular molecule. For experimental tools that are used to detect a gene product directly encoded by the genome, see instead 'gene product detection tag'." [FBC:GM, PMID:20664080]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005045
name: small molecule sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and confers a specific property that facilitates detection of a molecule that is not part of or directly encoded by the genome." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor

[Term]
id: FBcv:0005046
name: calcium ion sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of calcium ion concentration." [FBC:GM]
is_a: FBcv:0005045 ! small molecule sensor

[Term]
id: FBcv:0005047
name: pH sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of pH." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor

[Term]
id: FBcv:0005048
name: voltage sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of voltage." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor

[Term]
id: FBcv:0005049
name: redox state sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the redox state of a cell/tissue." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor

[Term]
id: FBcv:0005050
name: mechanical force sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of changes in the mechanical force the gene product is subjected to." [FBC:GM]
is_a: FBcv:0005044 ! genetically encoded sensor

[Term]
id: FBcv:0005051
name: split system component
namespace: experimental_tool_descriptor
def: "Component that forms part of a 'split system'. A split system component corresponds to a non-functional fragment of a functional experimental tool. When combined with another appropriate split system component in vivo, a functional experimental tool is produced. The fragments of a split system can be brought together in vivo in a number of different ways; for example, by fusing fragments to peptides that physically interact in vivo." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005052
name: split fluorescent protein
namespace: experimental_tool_descriptor
def: "Non-fluorescent fragment of a fluorescent protein. A functional fluorophore can be reconstituted if a split fluorescent protein fragment is expressed with a complementary split fluorescent protein fragment and the fragments are brought together in vivo, permitting the study of biological interactions. Protein-protein interactions can be studied using the bimolecular fluorescence complementation (BiFC) technique, where a fluorescent protein is reconstituted if the two complementary split fluorescent protein fragments are fused to interacting proteins or protein domains that bring the split halves together into the same macromolecular complex. Associations between closely apposed cells can be studied if the two complementary split fluorescent protein fragments are tethered to the surface of these cells, for example to study connectivity in the nervous system using the GFP Reconstitution Across Synaptic Partners (GRASP) technique." [FBC:GM, PMID:11983170, PMID:18255029]
is_a: FBcv:0009048 ! split protein detection tool

[Term]
id: FBcv:0005053
name: split reporter enzyme
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes a catalytically inactive fragment of an enzyme whose activity can be used to detect the presence of that protein product when complementary split reporter enzyme fragments are brought together in vivo. Fragments may be brought together when fused to peptides that physically interact, permitting the study of protein-protein interactions." [FBC:GM, http://orcid.org/0000-0002-1373-1705, PMID:9237989]
is_a: FBcv:0009048 ! split protein detection tool

[Term]
id: FBcv:0005054
name: split driver - DNA-binding fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that includes a DNA-binding domain and which can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment that encodes a transcription activation domain, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments." [FBC:GM]
is_a: FBcv:0009027 ! split driver fragment

[Term]
id: FBcv:0005055
name: split driver - transcription activation fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that includes a transcription activation domain and which can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment that encodes a DNA-binding domain, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments." [FBC:GM]
subset: common_tool_use
is_a: FBcv:0009027 ! split driver fragment

[Term]
id: FBcv:0005056
name: gene product cleavage tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which allows the tagged gene product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process." [FBC:GM]
is_a: FBcv:0009022 ! gene product engineering tool

[Term]
id: FBcv:0005057
name: protein cleavage tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which allows the tagged protein product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process. Examples of protein cleavage tags include sequences recognized and cleaved by proteases such as the human rhinovirus (HRV) 3C protease (often produced with the tradename PreScission Protease) and the tobacco etch virus (TEV) protease. Protein product cleavage can be used for a number of different purposes, including release of a protein after purification, or removal of a detection tag to assess that the tag does not interfere with protein function." [FBC:GM, FBC:TEMJ]
is_a: FBcv:0005056 ! gene product cleavage tag

[Term]
id: FBcv:0005058
name: binary expression system component
namespace: experimental_tool_descriptor
def: "Component that forms part of a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder." [FBC:GM, FlyBase:FBrf0216478]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005059
name: binary expression system - driver
namespace: experimental_tool_descriptor
def: "Transactivator ('driver') that is encoded by a transgenic locus or modified endogenous locus and which forms part of a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder." [FBC:GM, FlyBase:FBrf0216478]
subset: common_tool_use
is_a: FBcv:0005058 ! binary expression system component

[Term]
id: FBcv:0005060
name: binary expression system - regulatory region
namespace: experimental_tool_descriptor
def: "Specific DNA sequence that is used as the effector in a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder." [FBC:GM, FlyBase:FBrf0216478]
synonym: "binary expression system - effector" EXACT []
is_a: FBcv:0005058 ! binary expression system component
is_a: FBcv:0005082 ! engineered transcription regulatory region

[Term]
id: FBcv:0005061
name: binary expression system - repressor
namespace: experimental_tool_descriptor
def: "Repressor that can be used to regulate expression in a binary expression system. This system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder." [FBC:GM, FlyBase:FBrf0216478]
subset: common_tool_use
is_a: FBcv:0005058 ! binary expression system component

[Term]
id: FBcv:0005062
name: recombinase
namespace: experimental_tool_descriptor
def: "An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site. The recognition site for a particular site-specific recombinase is defined by the enzyme itself. The recognition site contains perfect inverted repeats flanking an asymmetric spacer. Under normal conditions, the two recognition sites are identical and are reformed during the recombination event, and thus the reaction is bidirectional: recombination can occur in both 'forward' and 'reverse' directions. However, recognition sites can be mutated to drive the directionality of the reaction: different classes of site may be combined so that recombination can occur in one direction, but produces reformed sites that are no longer compatible. In addition, mutually exclusive sites have been engineered for some recombinases. Recombinases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE)." [FlyBase:FBrf0231034]
subset: common_tool_use
synonym: "site-specific recombinase" EXACT []
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0005063
name: recombinase target site
namespace: experimental_tool_descriptor
def: "The recognition site for a particular site-specific recombinase, an enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a copy of the recognition site. The recognition site contains perfect inverted repeats flanking an asymmetric spacer. Under normal conditions, the two recognition sites are identical and are reformed during the recombination event, and thus the reaction is bidirectional: recombination can occur in both 'forward' and 'reverse' directions. However, recognition sites can be mutated to drive the directionality of the reaction: different classes of site may be combined so that recombination can occur in one direction, but produces reformed sites that are no longer compatible. In addition, mutually exclusive sites have been engineered for some recombinases. Recombinases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE)." [FlyBase:FBrf0231034]
synonym: "site-specific recombination target region" EXACT []
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0005064
name: binary expression system - conditional driver
namespace: experimental_tool_descriptor
def: "Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a conditional driver permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005059 ! binary expression system - driver

[Term]
id: FBcv:0005065
name: binary expression system - small molecule-regulated driver
namespace: experimental_tool_descriptor
def: "Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated by binding to a small molecule, such as an ion or ligand. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a small molecule-regulated driver permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005064 ! binary expression system - conditional driver

[Term]
id: FBcv:0005066
name: binary expression system - conditional repressor
namespace: experimental_tool_descriptor
def: "Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated in response to a particular stimulus. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a conditional repressor permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005061 ! binary expression system - repressor

[Term]
id: FBcv:0005067
name: binary expression system - temperature conditional repressor
namespace: experimental_tool_descriptor
def: "Repressor that can be used to regulate expression in a binary expression system and whose activity is regulated by temperature. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. In addition, a specific repressor protein may be available which prevents the transactivator from driving expression, allowing further refinement of the expression pattern of the responder. Use of a temperature conditional repressor permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005066 ! binary expression system - conditional repressor

[Term]
id: FBcv:0005068
name: insertional mutagenesis tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of a transgenic locus or modified endogenous locus and which is designed to impact or assess any proximate gene(s) when integrated into the genome." [FBC:GM, FBC:LC]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005069
name: enhancer trap
namespace: experimental_tool_descriptor
def: "An enhancer trap cassette is designed to report or utilize the expression of endogenous enhancer elements upon integration of the cassette into the genome. The basic components of an enhancer trap cassette are a minimal promoter element fused upstream of a gene. Upon integration into the genome, a neighboring genomic enhancer may activate expression of the gene encoded by the enhancer trap cassette. Depending on the nature of this gene, the insertion may directly report the expression pattern of the 'trapped' enhancer (e.g. if the gene encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encodes a driver that forms part of a binary expression system). An enhancer trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. An enhancer trap insertion can be mutagenic, disrupting the function of an endogenous locus, depending on the particular insertion site." [FBC:GM, FlyBase:FBrf0128252, FlyBase:FBrf0216478, PMID:10899970]
synonym: "enhancer detection tool" RELATED [FBC:GM]
xref: SO:0001479
is_a: FBcv:0005068 ! insertional mutagenesis tool

[Term]
id: FBcv:0005070
name: protein trap
namespace: experimental_tool_descriptor
def: "A protein trap cassette is designed to tag protein(s) encoded by an endogenous locus upon integration of the cassette into the genome. The basic structure of a protein trap cassette is an artificial exon composed of a splice acceptor site, an open reading frame without initiation and stop codons, and a splice donor site. No promoter sequences are present. Upon integration into a coding intron of an endogenous locus, the open reading frame (ORF) encoded by the artificial exon can be incorporated into ('tag') the protein encoded by the locus. This only occurs if the insertion is in the correct orientation and when the frame of the artificial exon corresponds to that of the preceeding exon. Thus, only one out of six insertions in a coding intron will function as a protein trap. To account for each reading frame, three versions of a given protein trap element, differing only in the splice phase, are typically produced for use in an insertional mutagenesis screen. Depending on the nature of the ORF encoded by the artificial exon, the tag may be used to detect the expression pattern and/or subcellular localization of the protein (e.g. if the tag is an epitope tag or fluorescent protein), to drive expression of a gene of interest (e.g. if the tag is a driver that forms part of a binary expression system), or may modify the properties of the endogenous protein (e.g. if the tag affects protein localization or stability). A protein trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. The presence of the splice acceptor and donor sites mean that a protein trap cassette is not inherently mutagenic, since it is designed to insert in frame into a protein. However, an insertion into an intron that splits a critical functional or localization domain may alter the activity of the encoded protein, and the protein trap tag sequence itself may be designed to alter function (for example targeting the protein to a new location within the cell or altering its stability)." [FBC:GM, FlyBase:FBrf0216478, FlyBase:FBrf0236840]
is_a: FBcv:0005068 ! insertional mutagenesis tool

[Term]
id: FBcv:0005071
name: gene trap
namespace: experimental_tool_descriptor
def: "A gene trap cassette is designed to interrupt transcription of an endogenous locus upon integration of the cassette into the genome. The basic components of a gene trap cassette are a promoterless gene with an upstream splice acceptor site. Upon integration into an intron, splicing from the genomic splice donor site to the splice acceptor site in the cassette results in a transcriptional fusion containing the endogenous exon(s) upstream of the insertion fused to the gene sequence encoded by the cassette. Any open reading frame (ORF) encoded by the trap cassette gene may be translated from this transcriptional fusion either as a translational fusion with any ORF sequence encoded by the upstream exons, or if an internal ribosome entry site (IRES) or viral 2A-like peptide sequence (which promotes ribosome skipping) is present upstream of the gene trap ORF, it may be produced as a separate protein expressed under the control of the regulatory sequences of the endogenous locus. Gene trap insertions are usually mutagenic, disrupting the locus into which they have inserted, since termination sequences are usually present at the 3' end of the cassette, truncating the endogenous transcript. Depending on the nature of the gene encoded by the gene trap cassette, a gene trap insertion may directly report the expression pattern of the disrupted locus (e.g. if it encodes a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest in the pattern of the trapped locus (e.g. if it is a driver that forms part of a binary expression system). A gene trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR." [FBC:GM, http://www.genetrap.org/tutorials/overview.html#vector, PMID:10899970]
xref: SO:0001477
is_a: FBcv:0005068 ! insertional mutagenesis tool

[Term]
id: FBcv:0005072
name: polyA trap
namespace: experimental_tool_descriptor
def: "The basic components of a polyA trap cassette are a promoter fused to a gene sequence that lacks a polyadenylation (polyA) sequence but is followed by a splice donor sequence. If the cassette is integrated into the genome outside a gene, the mRNA produced by the polyA trap is not polyadenylated and is expected to be rapidly degraded. However, if the cassette is integrated into an intron, the promoter in the polyA trap will drive expression of a transcriptional fusion containing the polyA gene trap fused to any downstream exons. The downstream terminal exon can provide a polyA signal, allowing stable expression of the gene encoded by the polyA trap. polyA trap cassettes can be used to report the expression of genes that are not normally expressed, or are expressed at very low levels, or may be used as a marker of successful integration of an insertion into a transcription unit. A polyA trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR." [FBC:GM, FlyBase:FBrf0132344, FlyBase:FBrf0206814, http://www.genetrap.org/tutorials/overview.html#vector, PMID:9560157]
is_a: FBcv:0005068 ! insertional mutagenesis tool

[Term]
id: FBcv:0005073
name: promoter trap
namespace: experimental_tool_descriptor
def: "The basic component of a promoter trap cassette is a promoterless gene. This gene is not flanked by splice acceptor or donor sites, and thus the gene within a promoter trap can only be expressed if the cassette integrates into the genome within an exon, resulting in a transcriptional fusion. If the promoter trap gene encodes an open reading frame (ORF) and the insertion is in the correct frame, the trap ORF may be translated from this transcriptional fusion either as a translational fusion with ORF sequence of the disrupted endogenous locus, or if an internal ribosome entry site (IRES) or viral 2A-like peptide sequence (which promotes ribosome skipping) is present upstream of the promoter trap ORF, it may be produced as a separate protein expressed under the control of the regulatory sequences of the endogenous locus. Depending on the nature of the gene encoded by the promoter trap cassette, the insertion may directly report the expression pattern of the 'trapped' locus (e.g. if the gene encoded by the cassette is a reporter enzyme or fluorescent protein), or it may be used to drive expression of any gene of interest (e.g. if the gene encoded by the cassette is a driver that form part of a binary expression system). A promoter trap cassette may be inserted into a genome as part of a transgenic construct via transposable-element-mediated transgenesis, or may be inserted directly into a modified endogenous locus via a genome engineering method such as homologous recombination or CRISPR. Promoter trap insertions are usually mutagenic, disrupting the locus into which they have inserted, since termination sequences are usually present at the 3' end of the cassette, truncating the endogenous transcript." [FBC:GM, PMID:10899970]
is_a: FBcv:0005068 ! insertional mutagenesis tool

[Term]
id: FBcv:0005074
name: misexpression element
namespace: experimental_tool_descriptor
def: "The basic components of a misexpression element are an enhancer sequence plus a minimal promoter. Upon integration into the genome, this element can activate expression of nearby endogenous loci. Typically, constructs containing misexpression elements are designed to insert at or near the 5' end of a gene, such that expression from the promoter within the misexpression element drives overexpression of the endogenous locus and causes a gain-of-function phenotype. However, if the insertion is within a locus, a truncated product may be produced, while an insertion in the opposite orientation to that of the direction of transcription of the endogenous locus can result in the production of an antisense transcript. If the enhancer present in the misexpression element forms part of a binary expression system, the misexpression pattern of the endogenous gene is controlled by combining the misexpression element insertion with a driver expressed in the desired temporal and spatial pattern." [FBC:GM, FlyBase:FBrf0090768]
is_a: FBcv:0005068 ! insertional mutagenesis tool

[Term]
id: FBcv:0005075
name: genome engineering tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to an modify an organism's genetic material in a defined manner. Genome engineering can occur on many levels, ranging from targeting of an individual gene with a small modification through to the engineering of chromosomal rearrangements. In addition to the manipulation of endogenous loci, genome engineering can also be used to introduce exogenous material into the genome, and to manipulate such exogenous material already introduced the genome." [FlyBase:FBrf0231034]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005076
name: integrase
namespace: experimental_tool_descriptor
def: "An enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE)." [FlyBase:FBrf0231034]
subset: common_tool_use
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0005077
name: nuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome." [FBC:GM, FlyBase:FBrf0231034]
subset: common_tool_use
synonym: "site-specific DNA nuclease" RELATED [FBC:GM]
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0005078
name: RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, and in which the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest, rather than being an inherent property of the nuclease itself." [FBC:GM, FlyBase:FBrf0231034]
subset: common_tool_use
is_a: FBcv:0005077 ! nuclease

[Term]
id: FBcv:0005079
name: integrase target site
namespace: experimental_tool_descriptor
def: "A recognition site for an integrase, an enzyme that mediates an exchange reaction between two DNA templates, resulting in integration of DNA from one of the templates into the other. An integrase binds a pair of compatible recognition sites (typically called attP and attB) which each contain a short integration core flanked by imperfect inverted repeats that are not identical. Exchange between the attP/attB pair results in the formation of hybrid sites (typically called attL and attR) that are no longer a substrate of the integrase. Thus the exchange reaction driven by an integrase is unidirectional. Mutually exclusive pairs of recognition site have been engineered for some integrases. Integrases can be used to generate many different types of genetic modification, with the outcome being influenced by the relative orientation (direct or inverted), relative location and composition of the two recognition sites. The types of possible modification include deletion of DNA, generation of chromosomal rearrangements, integration of DNA into the genome, and replacement of genetic material with that from a donor plasmid using recombination-mediated cassette exchange (RMCE)." [FlyBase:FBrf0231034]
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0005080
name: nuclease target site
namespace: experimental_tool_descriptor
def: "A recognition site for a site-specific DNA nuclease, an enzyme that catalyzes hydrolysis of DNA in a site-specific manner. The DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome." [FBC:GM, FlyBase:FBrf0231034]
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0005081
name: engineered regulatory region
namespace: experimental_tool_descriptor
def: "Engineered sequence that forms all or part of a transgenic locus or modified endogenous locus and that has the property of a 'regulatory_region' (SO:0005836). 'regulatory_region' is defined as 'A region of sequence that is involved in the control of a biological process." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0005082
name: engineered transcription regulatory region
namespace: experimental_tool_descriptor
def: "Engineered sequence that forms all or part of a transgenic locus or modified endogenous locus and that has the property of a 'transcription_regulatory_region' (SO:0001679). 'transcription_regulatory_region' is defined as 'A regulatory region that is involved in the control of the process of transcription.'." [FBC:GM]
is_a: FBcv:0005081 ! engineered regulatory region

[Term]
id: FBcv:0005083
name: small molecule-regulated degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by a small molecule." [FBC:GM]
synonym: "small molecule-dependent gene product degradation tag" EXACT []
synonym: "small molecule-regulated gene product degradation tag" EXACT []
is_a: FBcv:0009016 ! conditional degradation tag

[Term]
id: FBcv:0006000
name: abnormal copulation
namespace: phenotypic_class
def: "Phenotype that is any abnormality in copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'" [FBC:TEMJ, ISBN:0721662544]
synonym: "copulation defective" EXACT []
is_a: FBcv:0000721 ! abnormal mating behavior

[Term]
id: FBcv:0006001
name: increased fecundity
namespace: phenotypic_class
def: "Phenotype that is an increase in the number of gametes produced." [FBC:TEMJ]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0006002
name: decreased fecundity
namespace: phenotypic_class
def: "Phenotype that is a decrease in the number of gametes produced." [FBC:TEMJ]
synonym: "reduced fecundity" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0006003
name: population of Drosophila

[Term]
id: FBcv:0006004
name: abnormal oviposition
namespace: phenotypic_class
def: "Phenotype that is any abnormality in oviposition (GO:0018991) despite production of eggs. 'oviposition' is defined as: 'A reproductive behavior that results in the deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.'." [FBC:TEMJ, GOC:ems, PMID:18050396, PMID:31164023]
comment: This term should only be used to report defects specifically in oviposition, as opposed to an overall loss of fertility. It is not possible to observe an oviposition abnormality if eggs are not being produced. If a difference in "oviposition rate" is measured by authors as a proxy for sterility/fertility, it would be better to use the terms "sterile", "semi-sterile", or "semi-fertile", as appropriate.
synonym: "oviposition defective" EXACT []
is_a: FBcv:0000387 ! abnormal behavior

[Term]
id: FBcv:0006005
name: increased occurrence of cell division
namespace: phenotypic_class
def: "A phenotype that is an increased occurrence of cell division (GO:0051301). 'cell division' is defined as 'The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.'." [FBC:TEMJ, GOC:di, GOC:go_curators, GOC:pr]
subset: fbcvsubset_mgiribbons
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0006006
name: decreased occurrence of cell division
namespace: phenotypic_class
def: "A phenotype that is a decreased occurrence of cell division (GO:0051301). 'cell division' is defined as 'The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.'." [FBC:TEMJ, GOC:di, GOC:go_curators, GOC:pr]
subset: fbcvsubset_mgiribbons
synonym: "reduced occurrence of cell division" EXACT []
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0006007
name: population of cells

[Term]
id: FBcv:0007000
name: obsolete micropublication
namespace: pub_type
def: "A short report describing a single stand-alone research finding that is peer-reviewed and published." [FBC:SM, http://www.micropublication.org]
comment: Obsoleted, as 'paper' publication type will now be used for micropublications.
is_obsolete: true
replaced_by: FBcv:0000212

[Term]
id: FBcv:0007001
name: preprint
namespace: pub_type
def: "A version of a scientific manuscript that is shared publicly on the web without peer review. In most cases, work posted as a preprint will be submitted for peer review at a journal." [FBC:SM, http://www.asapbio.org/preprint-info]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0007002
name: neuron activity regulation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to regulate the activity of a neuron. This is often achieved by manipulation of membrane potential or synaptic transmission dynamics." [FBC:GM]
subset: common_tool_use
synonym: "electrically signalling cell activity regulation tool" EXACT []
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0007003
name: neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron. This is often achieved by inducing membrane hyperpolarization (GO:0060081)." [FBC:GM]
synonym: "electrically signalling cell inhibition tool" EXACT []
is_a: FBcv:0007002 ! neuron activity regulation tool

[Term]
id: FBcv:0007004
name: conditional neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007003 ! neuron inhibition tool

[Term]
id: FBcv:0007005
name: light-regulated neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
synonym: "optogenetic neuron inhibition tool" EXACT []
is_a: FBcv:0007004 ! conditional neuron inhibition tool

[Term]
id: FBcv:0007006
name: small molecule-regulated neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007004 ! conditional neuron inhibition tool

[Term]
id: FBcv:0007007
name: temperature-regulated neuron inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to inhibit the activity of a neuron, where this property can be regulated by temperature." [FBC:GM]
synonym: "thermogenetic neuron inhibition tool" EXACT []
is_a: FBcv:0007004 ! conditional neuron inhibition tool

[Term]
id: FBcv:0007008
name: neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron. This is often achieved by inducing membrane depolarization (GO:0051899)." [FBC:GM]
synonym: "electrically signalling cell activation tool" EXACT []
is_a: FBcv:0007002 ! neuron activity regulation tool

[Term]
id: FBcv:0007009
name: conditional neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007008 ! neuron activation tool

[Term]
id: FBcv:0007010
name: temperature-regulated neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by temperature." [FBC:GM]
synonym: "thermogenetic neuron activation tool" EXACT []
is_a: FBcv:0007009 ! conditional neuron activation tool

[Term]
id: FBcv:0007011
name: light-regulated neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
synonym: "optogenetic neuron activation tool" EXACT []
is_a: FBcv:0007009 ! conditional neuron activation tool

[Term]
id: FBcv:0007012
name: small molecule-regulated neuron activation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to stimulate the activity of a neuron, where this property can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007009 ! conditional neuron activation tool

[Term]
id: FBcv:0007013
name: cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure." [FBC:GM]
subset: common_tool_use
is_a: FBcv:0009043 ! cell viability regulation tool

[Term]
id: FBcv:0007014
name: conditional cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007013 ! cell ablation tool

[Term]
id: FBcv:0007015
name: temperature-regulated cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by temperature." [FBC:GM]
is_a: FBcv:0007014 ! conditional cell ablation tool

[Term]
id: FBcv:0007016
name: light-regulated cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0007014 ! conditional cell ablation tool

[Term]
id: FBcv:0007017
name: small molecule-regulated cell ablation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to ablate a specific cell or anatomical structure, where this property can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007014 ! conditional cell ablation tool

[Term]
id: FBcv:0007018
name: biological process activity sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activity of a specific biological process." [FBC:GM]
synonym: "reporter of biological process pathway activity" EXACT []
is_a: FBcv:0005044 ! genetically encoded sensor

[Term]
id: FBcv:0007019
name: signal transduction pathway activity sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activity of a specific signal transduction pathway." [FBC:GM]
synonym: "reporter of signal transduction pathway activity" EXACT []
is_a: FBcv:0007018 ! biological process activity sensor

[Term]
id: FBcv:0007020
name: gene product activity sensor
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that is used to provide a readout of the activation state of a specific gene product." [FBC:GM]
synonym: "gene product activation state detection tool" EXACT []
is_a: FBcv:0005044 ! genetically encoded sensor

[Term]
id: FBcv:0007021
name: proximity labeling tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring macromolecules, facilitating the subsequent purification or detection of the tagged macromolecules by an experimental method." [FBC:GM, PMID:30774936]
subset: common_tool_use
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0007022
name: proximity labeling tool (protein)
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring proteins, facilitating the subsequent purification or detection of the tagged proteins by an experimental method." [FBC:GM, PMID:29125959, PMID:30774936]
is_a: FBcv:0007021 ! proximity labeling tool

[Term]
id: FBcv:0007023
name: proximity labeling tool (RNA)
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring RNA, facilitating the subsequent purification or detection of the tagged RNA by an experimental method." [FBC:GM, PMID:30774936]
is_a: FBcv:0007021 ! proximity labeling tool

[Term]
id: FBcv:0007024
name: proximity labeling tool (DNA)
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme which covalently tags neighboring DNA, facilitating the subsequent purification or detection of the tagged DNA by an experimental method." [FBC:GM, PMID:30774936]
is_a: FBcv:0007021 ! proximity labeling tool

[Term]
id: FBcv:0007025
name: cell labeling tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property that can be used to facilitate the detection of a specific cell population by an experimental method." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0007026
name: multicolor cell labeling tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and confers a specific property that can be used to stochastically label cells in the same sample with different colors of fluorescent protein. This property can be exploited to study cell morphology and to track lineages of clonally related cells." [FBC:GM, PMID:25491327]
is_a: FBcv:0007025 ! cell labeling tool

[Term]
id: FBcv:0007027
name: small molecule-regulated protein cleavage tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which allows the tagged protein product to be cleaved (broken into smaller molecules by the rupture of a covalent bond) by a specific process that can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0005057 ! protein cleavage tag

[Term]
id: FBcv:0007028
name: split recombinase
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a recombinase. A functional recombinase can be reconstituted when complementary split recombinase fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0009045 ! split genome engineering tool

[Term]
id: FBcv:0007029
name: specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule." [FBC:GM]
subset: common_tool_use
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0007030
name: conditional specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007029 ! specific binding tool

[Term]
id: FBcv:0007031
name: light-regulated specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0007030 ! conditional specific binding tool

[Term]
id: FBcv:0007032
name: temperature-regulated specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by temperature." [FBC:GM]
is_a: FBcv:0007030 ! conditional specific binding tool

[Term]
id: FBcv:0007033
name: small molecule-regulated specific binding tool
namespace: experimental_tool_descriptor
def: "Sequence that has a property that allows specific binding to another macromolecule, where this property can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007030 ! conditional specific binding tool

[Term]
id: FBcv:0007034
name: signaling pathway group
namespace: group_descriptor
def: "Genes whose products act in a specified signal transduction pathway." [FBC:SM]
is_a: FBcv:0003017 ! pathway group

[Term]
id: FBcv:0007035
name: meganuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, having a cognate recognition site of 20-30bp. When used in vivo, the DNA cutting stimulates cellular repair mechanisms, which can be exploited to produce genome modifications. For example, repair by homologous recombination in the presence of an exogenous template can be used to introduce targeted changes into the genome." [FBC:GM, FlyBase:FBrf0231034]
is_a: FBcv:0005077 ! nuclease

[Term]
id: FBcv:0007036
name: lecture
namespace: pub_type
def: "Work consisting of speeches read or delivered before an audience or class, especially for instruction or to set forth some subject." [MeSH:D019531]
is_a: FBcv:0000189 ! publication class

[Term]
id: FBcv:0007037
name: antibody
namespace: experimental_tool_descriptor
def: "An immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact with the antigen that induced its synthesis and with molecules containing structures similar to that antigen. An antigen is any substance capable of inducing a specific immune response, including but not limited to toxins, bacterial proteins and viruses." [XCO:0000194]
subset: common_tool_use
xref: XCO:0000194
is_a: FBcv:0007029 ! specific binding tool

[Term]
id: FBcv:0007038
name: light conditional
namespace: environmental_qualifier
def: "Phenotype expressed only in the presence or absence of light, which may be white light or particular wavelength(s)." [FBC:CP]
is_a: FBcv:0000309 ! conditional

[Term]
id: FBcv:0007039
name: engineered antibody
namespace: experimental_tool_descriptor
def: "An antibody whose domain architecture has been engineered in vitro. An engineered antibody typically contains only a subset of the domains found in a naturally occurring antibody. In some cases, domains that are normally found in different chains of a naturally occurring antibody are synthesized as a single fusion protein." [FBC:GM]
is_a: FBcv:0007037 ! antibody

[Term]
id: FBcv:0007040
name: nanobody
namespace: experimental_tool_descriptor
def: "An engineered antibody consisting of the antigen-binding variable domain (VHH domain) of a camelid single-domain heavy chain antibody (HCab)." [FBC:GM, PMID:22886243, PMID:8502296, PMID:9323027]
is_a: FBcv:0007039 ! engineered antibody

[Term]
id: FBcv:0007041
name: single-chain variable fragment antibody
namespace: experimental_tool_descriptor
def: "An engineered antibody consisting of the heavy (VH) and light (VL) chains of an immunoglobulin, separated by a short flexible linker peptide and expressed as a single fusion protein." [FBC:GM, PMID:3045807]
synonym: "scFv antibody" EXACT [FBC:GM]
synonym: "sFv antibody" EXACT [PMID:3045807]
synonym: "single-chain variable region fragment antibody" EXACT [PMID:3045807]
is_a: FBcv:0007039 ! engineered antibody

[Term]
id: FBcv:0007042
name: RMCE target element
namespace: experimental_tool_descriptor
def: "An RMCE target element contains a region of DNA sequence flanked by a pair of target sites for a recombinase or an integrase, which are arranged such that this target sequence cassette can be replaced with donor sequence from a compatible RMCE donor element via recombination-mediated cassette exchange (RMCE). For RMCE mediated by a recombinase, the target cassette is flanked by two non-identical recombinase target sites that each carry a different mutation in the spacer sequence of the target site; this renders the two sites incompatible with each other. A compatible RMCE donor cassette is flanked by the same pair of non-identical sites; in the presence of recombinase, a double recombination event between the identical sites on the donor and target sequences results in replacement of the target cassette with the donor cassette. In the case of RMCE mediated by an integrase, the RMCE cassette is flanked by identical integrase target sites, while a compatible RMCE donor cassette is flanked by copies of the orthogonal integrase target site; in the presence of integrase, a double recombination event results in the target cassette being replaced with that of the donor cassette. In this case, if the flanking sites are in inverted orientation, replacement of the target cassette can occur in either direction." [FBC:GM, FlyBase:FBrf0231034, PMID:21445009, PMID:7947678]
synonym: "recombination-mediated cassette exchange target element" EXACT []
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0007043
name: RMCE donor element
namespace: experimental_tool_descriptor
def: "An RMCE donor element contains a region of DNA sequence flanked by a pair of target sites for a recombinase or an integrase, which are arranged such that this donor sequence cassette can be used to replace target sequence of a compatible RMCE target element via recombination-mediated cassette exchange (RMCE). For RMCE mediated by a recombinase, the target cassette is flanked by two non-identical recombinase target sites that each carry a different mutation in the spacer sequence of the target site; this renders the two sites incompatible with each other. A compatible RMCE donor cassette is flanked by the same pair of non-identical sites; in the presence of recombinase, a double recombination event between the identical sites on the donor and target sequences results in replacement of the target cassette with the donor cassette. In the case of RMCE mediated by an integrase, the RMCE cassette is flanked by identical integrase target sites, while a compatible RMCE donor cassette is flanked by copies of the orthogonal integrase target site; in the presence of integrase, a double recombination event results in the target cassette being replaced with that of the donor cassette. In this case, if the flanking sites are in inverted orientation, replacement of the target cassette can occur in either direction." [FBC:GM, FlyBase:FBrf0231034, PMID:21445009, PMID:7947678]
synonym: "recombination-mediated cassette exchange donor element" EXACT []
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0007044
name: docking element
namespace: experimental_tool_descriptor
def: "A docking element is an element that has been introduced into a site in the genome to allow integration of DNA at a defined location; this neutralizes the problem of position effects that are seen with non-specific insertion techniques such as transposable-element-mediated transgenesis. A docking element contains a single target site for an integrase, allowing subsequent integration of DNA into this site from a donor element via integrase mediated recombination. The docking element in the genome typically contains the 'attB' site and the donor plasmid contains the 'attP' site, since this directionality gives higher integration rates compared to the alternative combination where the 'attB' site is integrated into the genome. A docking element insertion is typically selected to be 'benign' (that is it does not result in disruption of an endogenous locus) and to show a high rate of integration in the presence of integrase." [FBC:GM, FlyBase:FBrf0192974, FlyBase:FBrf0194996, FlyBase:FBrf0231034, PMID:11359900, PMID:12563279]
comment: This includes any element containing a single site for integrase-mediated integration, as in FBrf0231034 Fig 10a, but not elements with multiple integrase sites, as in FBrf0231034 Fig 10b (see FBcv:0007042 - RMCE target element). Elements with sites for recombinase-mediated exchange (as in FBrf0231034 Fig 10c) are only included if they additionally carry exactly one integrase site for integrase-mediated integration.
synonym: "docking site element" EXACT []
synonym: "landing site element" EXACT []
is_a: FBcv:0005075 ! genome engineering tool

[Term]
id: FBcv:0007045
name: RNA engineering tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to modify an RNA of interest in a defined manner. Examples of RNA engineering include the targeting of an individual transcript for knockdown, and targeted manipulation of RNA splicing or editing." [FBC:GM, PMID:30021724, PMID:30388409, PMID:31367845]
subset: common_tool_use
is_a: FBcv:0009022 ! gene product engineering tool

[Term]
id: FBcv:0007046
name: RNA-guided ribonuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of RNA in a site-specific manner, and in which the specificity is determined by a guide RNA that contains sequence complementary to the target RNA sequence of interest, rather than being an inherent property of the ribonuclease itself. This property can be used to modify an organism's transcriptome in a defined manner." [FBC:GM, PMID:30021724, PMID:30388409, PMID:31367845]
subset: common_tool_use
is_a: FBcv:0007045 ! RNA engineering tool

[Term]
id: FBcv:0007047
name: light-regulated degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
synonym: "light-regulated gene product degradation tag" EXACT []
is_a: FBcv:0009016 ! conditional degradation tag

[Term]
id: FBcv:0007048
name: decreased number
namespace: structural_qualifier
def: "Present in the correct location but in smaller numbers than in wild-type." [FBC:CP]
is_a: FBcv:0000014 ! structural qualifier

[Term]
id: FBcv:0007049
name: absent
namespace: structural_qualifier
def: "Anatomical structure that would be present in wild-type is not present." [FBC:CP]
xref: PATO:0000462
is_a: FBcv:0000014 ! structural qualifier

[Term]
id: FBcv:0007050
name: somatic clone - tissue specific
namespace: clone_qualifier
def: "A clone of somatic cells that share a genotype that is different from the genotype of the animal and are intentionally generated in a specific tissue of the organism." [FBC:AO]
is_a: FBcv:0000336 ! somatic clone

[Term]
id: FBcv:0007051
name: somatic clone - tissue specific, Minute background
namespace: clone_qualifier
def: "A clone of somatic cells that share a mutant genotype that includes being Minute +/+ and that are part of and derived from an animal with a different genotype that includes being Minute +/- and are intentionally generated in a specific tissue of the organism." [FBC:CP]
is_a: FBcv:0000722 ! somatic clone - Minute background
is_a: FBcv:0007050 ! somatic clone - tissue specific

[Term]
id: FBcv:0007052
name: light-regulated nuclear export signal
namespace: experimental_tool_descriptor
def: "A peptide sequence used to target a tagged protein for export from the nucleus to the cytoplasm, where this property can be regulated by irradiation with a pulse of light." [FBC:GM, FlyBase:FBrf0253050, PMID:26853913]
is_a: FBcv:0005035 ! nuclear export signal

[Term]
id: FBcv:0007053
name: obsolete conditional split driver - transcription activation fragment
def: "Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by a particular stimulus. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
is_obsolete: true
consider: FBcv:0005055
consider: FBcv:0009028

[Term]
id: FBcv:0007054
name: obsolete light-regulated split driver - transcription activation fragment
def: "Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by irradiation with a pulse of light. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate light stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
is_obsolete: true
consider: FBcv:0005055
consider: FBcv:0009029

[Term]
id: FBcv:0007055
name: obsolete small molecule-regulated split driver - transcription activation fragment
def: "Sequence encoding a transcription activation domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by binding to a small molecule, such as an ion or ligand. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a DNA-binding domain fused to the complementary heterodimerization domain and the appropriate small molecule stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
is_obsolete: true
consider: FBcv:0005055
consider: FBcv:0009030

[Term]
id: FBcv:0007056
name: obsolete conditional split driver - DNA-binding fragment
def: "Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by a particular stimulus. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
is_obsolete: true
consider: FBcv:0005054
consider: FBcv:0009028

[Term]
id: FBcv:0007057
name: obsolete light-regulated split driver - DNA-binding fragment
def: "Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by irradiation with a pulse of light. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate light stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
is_obsolete: true
consider: FBcv:0005054
consider: FBcv:0009029

[Term]
id: FBcv:0007058
name: obsolete small molecule-regulated split driver - DNA-binding fragment
def: "Sequence encoding a site-specific DNA-binding domain fused to a heterodimerization domain, where the process of heterodimerization mediated by this domain can be regulated by binding to a small molecule, such as an ion or ligand. A functional transcription driver can be reconstituted in vivo if this split system component is brought together with a split system component that encodes a transcription activation domain fused to the complementary heterodimerization domain and the appropriate small molecule stimulus is applied." [FBC:GM]
comment: Obsoleted in favor of terms that do not conflate the type of the fragment with the type of conditional regulation.
is_obsolete: true
consider: FBcv:0005054
consider: FBcv:0009030

[Term]
id: FBcv:0007059
name: conditional recombinase
namespace: experimental_tool_descriptor
def: "An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site (defined by the enzyme itself), where the activity of the enzyme can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0005062 ! recombinase

[Term]
id: FBcv:0007060
name: small molecule-regulated recombinase
namespace: experimental_tool_descriptor
def: "An enzyme that mediates a recombination exchange reaction between two DNA templates, each containing a specific recognition site (defined by the enzyme itself), where the activity of the enzyme can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0007059 ! conditional recombinase

[Term]
id: FBcv:0007061
name: conditional split recombinase
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a recombinase that can be used to reconstitute a functional recombinase when brought together in vivo with a complementary split recombinase fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0007028 ! split recombinase

[Term]
id: FBcv:0007062
name: light-regulated split recombinase
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a recombinase that can be used to reconstitute a functional recombinase when brought together in vivo with a complementary split recombinase fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0007061 ! conditional split recombinase

[Term]
id: FBcv:0007063
name: light-regulated nuclear protein localization tag
namespace: experimental_tool_descriptor
def: "A peptide sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which is used to target the tagged protein to the nucleus, where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0005024 ! nuclear protein localization tag

[Term]
id: FBcv:0007064
name: binary expression system - light-regulated driver
namespace: experimental_tool_descriptor
def: "Transactivator ('driver') that forms part of a binary expression system and whose activity is regulated by irradiation with a pulse of light. A binary expression system requires a transactivator ('driver') that binds to a specific DNA sequence ('regulatory region' or 'effector'). A driver encoded by one transgenic locus or modified endogenous locus is used to drive expression of a downstream 'responder' or 'reporter' encoded by another transgenic locus or modified endogenous locus, by fusing the regulatory region sequence to which the driver binds upstream of the responder sequence. The temporal and spatial expression pattern of the responder thus depends on the regulatory elements used to drive expression of the driver. Use of a light-regulated driver permits further refinement of this expression pattern." [FBC:GM]
is_a: FBcv:0005064 ! binary expression system - conditional driver

[Term]
id: FBcv:0007065
name: metabolic pathway group
namespace: group_descriptor
def: "Genes whose products act in a specified metabolic pathway." [FBC:SM]
is_a: FBcv:0003017 ! pathway group

[Term]
id: FBcv:0007066
name: chemical labeling reporter
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity results in covalent tagging of the protein product with a small molecule whose properties (typically fluorescence) can be used to detect the presence of that protein product." [FBC:GM]
subset: common_tool_use
is_a: FBcv:0005005 ! reporter enzyme

[Term]
id: FBcv:0007067
name: bioluminescence reporter
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the protein product encoded by a transgenic locus or modified endogenous locus and that encodes an enzyme whose activity results in bioluminescence, which can be used to detect the presence of that protein product." [FBC:GM]
is_a: FBcv:0005005 ! reporter enzyme

[Term]
id: FBcv:0007068
name: gene product degradation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and which can be used to target a gene product for degradation in a defined manner." [FBC:GM]
comment: Degradation tool may or may not be fused directly to the degradation target.
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0007500
name: abnormal anesthesia-resistant memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in anesthesia-resistant memory (GO:0007615). 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.'" [PMID:15143285, PMID:17088531]
is_a: FBcv:0000398 ! abnormal memory

[Term]
id: FBcv:0007501
name: abnormal short-term memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in short-term memory (GO:0007614). 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.'" [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
is_a: FBcv:0000398 ! abnormal memory

[Term]
id: FBcv:0007502
name: abnormal medium-term memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in medium-term memory (GO:0072375). 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).'" [GOC:sart, PMID:14659098, PMID:7923375]
is_a: FBcv:0000398 ! abnormal memory

[Term]
id: FBcv:0007503
name: abnormal long-term memory
namespace: phenotypic_class
def: "Phenotype that is any abnormality in long-term memory (GO:0007616). 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.'" [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
is_a: FBcv:0000398 ! abnormal memory

[Term]
id: FBcv:0007504
name: abnormal body weight
namespace: phenotypic_class
def: "Phenotype that is any abnormality in body weight compared to identically raised wild-type controls." [FBC:CP]
is_a: FBcv:0001347 ! phenotype

[Term]
id: FBcv:0007505
name: increased body weight
namespace: phenotypic_class
def: "Phenotype that is an increase in body weight compared to identically raised wild-type controls." [FBC:CP]
is_a: FBcv:0007504 ! abnormal body weight

[Term]
id: FBcv:0007506
name: decreased body weight
namespace: phenotypic_class
def: "Phenotype that is a decrease in body weight compared to identically raised wild-type controls." [FBC:CP]
synonym: "reduced body weight" EXACT []
is_a: FBcv:0007504 ! abnormal body weight

[Term]
id: FBcv:0007507
name: increased size
namespace: phenotypic_class
def: "A phenotype that is an increase in the size of the whole body or some body part compared to wild-type." [FBC:CP]
is_a: FBcv:0000357 ! abnormal size

[Term]
id: FBcv:0007508
name: decreased size
namespace: phenotypic_class
def: "A phenotype that is a decrease in the size of the whole body or some body part compared to wild-type." [FBC:CP]
synonym: "reduced size" EXACT []
is_a: FBcv:0000357 ! abnormal size

[Term]
id: FBcv:0007509
name: increased rate of phototaxis
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.'" [FBC:CP, GOC:jl, ISBN:0192800981]
is_a: FBcv:0000413 ! abnormal phototaxis

[Term]
id: FBcv:0007510
name: decreased rate of phototaxis
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of phototaxis (GO:0042331). 'phototaxis' is defined as: 'The directed movement of a motile cell or organism in response to light.'" [FBC:CP, GOC:jl, ISBN:0192800981]
synonym: "reduced rate of phototaxis" EXACT []
is_a: FBcv:0000413 ! abnormal phototaxis

[Term]
id: FBcv:0007511
name: increased rate of cell adhesion
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.'" [FBC:CP, GOC:hb, GOC:pf]
is_a: FBcv:0000668 ! abnormal cell adhesion

[Term]
id: FBcv:0007512
name: decreased rate of cell adhesion
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of cell adhesion (GO:0007155). 'cell adhesion' is defined as: 'The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.'" [FBC:CP, GOC:hb, GOC:pf]
synonym: "reduced rate of cell adhesion" EXACT []
is_a: FBcv:0000668 ! abnormal cell adhesion

[Term]
id: FBcv:0007513
name: increased sleep
namespace: phenotypic_class
def: "Phenotype that is an increase in the total amount or frequency of sleep (GO:0030431) over a given time interval, compared to wild-type. 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.'" [FBC:CP, ISBN:0192800981]
is_a: FBcv:0000705 ! abnormal sleep

[Term]
id: FBcv:0007514
name: decreased sleep
namespace: phenotypic_class
def: "Phenotype that is a decrease in the total amount or frequency of sleep (GO:0030431) over a given time interval, compared to wild-type. 'sleep' is defined as: 'Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.'" [FBC:CP, ISBN:0192800981]
synonym: "reduced sleep" EXACT []
is_a: FBcv:0000705 ! abnormal sleep

[Term]
id: FBcv:0007515
name: increased rate of feeding behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in the total amount or frequency of feeding behavior (GO:0007631) over a given time interval, compared to wild-type. 'feeding behavior' is defined as: 'Behavior associated with the intake of food.'" [FBC:DOS, GOC:mah]
is_a: FBcv:0000419 ! abnormal feeding behavior

[Term]
id: FBcv:0007516
name: decreased rate of feeding behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in the total amount or frequency of feeding behavior (GO:0007631) over a given time interval, compared to wild-type. 'feeding behavior' is defined as: 'Behavior associated with the intake of food.'" [FBC:DOS, GOC:mah]
synonym: "reduced rate of feeding behavior" EXACT []
is_a: FBcv:0000419 ! abnormal feeding behavior

[Term]
id: FBcv:0007517
name: increased efficacy of memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of memory (GO:0007613) relative to controls. 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).'" [FBC:CP, GOC:curators, ISBN:0582227089]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with memory formation.
synonym: "improved memory" EXACT []
is_a: FBcv:0000398 ! abnormal memory

[Term]
id: FBcv:0007518
name: decreased efficacy of memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of memory (GO:0007613) relative to controls. 'memory' is defined as: 'The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).'" [FBC:CP, GOC:curators, ISBN:0582227089]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with memory formation.
synonym: "impaired memory" EXACT []
synonym: "reduced efficacy of memory" EXACT []
is_a: FBcv:0000398 ! abnormal memory

[Term]
id: FBcv:0007519
name: increased efficacy of short-term memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of short-term memory (GO:0007614) relative to controls. 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.'" [FBC:CP, http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with short-term memory formation.
is_a: FBcv:0007501 ! abnormal short-term memory
is_a: FBcv:0007517 ! increased efficacy of memory

[Term]
id: FBcv:0007520
name: decreased efficacy of short-term memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of short-term memory (GO:0007614) relative to controls. 'short-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.'" [FBC:CP, http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with short-term memory formation.
synonym: "reduced efficacy of short-term memory" EXACT []
is_a: FBcv:0007501 ! abnormal short-term memory
is_a: FBcv:0007518 ! decreased efficacy of memory

[Term]
id: FBcv:0007521
name: increased efficacy of long-term memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of long-term memory (GO:0007616) relative to controls. 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.'" [FBC:CP, http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with long-term memory formation.
is_a: FBcv:0007503 ! abnormal long-term memory
is_a: FBcv:0007517 ! increased efficacy of memory

[Term]
id: FBcv:0007522
name: decreased efficacy of long-term memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of long-term memory (GO:0007616) relative to controls. 'long-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.'" [FBC:CP, http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with long-term memory formation.
synonym: "reduced efficacy of long-term memory" EXACT []
is_a: FBcv:0007503 ! abnormal long-term memory
is_a: FBcv:0007518 ! decreased efficacy of memory

[Term]
id: FBcv:0007523
name: increased efficacy of anesthesia-resistant memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of anesthesia-resistant memory (GO:0007615) relative to controls. 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.'" [FBC:CP, PMID:15143285, PMID:17088531]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with anesthesia-resistant memory formation.
is_a: FBcv:0007500 ! abnormal anesthesia-resistant memory
is_a: FBcv:0007517 ! increased efficacy of memory

[Term]
id: FBcv:0007524
name: decreased efficacy of anesthesia-resistant memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of anesthesia-resistant memory (GO:0007615) relative to controls. 'anesthesia-resistant memory' is defined as: 'The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.'" [FBC:CP, PMID:15143285, PMID:17088531]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with anesthesia-resistant memory formation.
synonym: "reduced efficacy of anesthesia-resistant memory" EXACT []
is_a: FBcv:0007500 ! abnormal anesthesia-resistant memory
is_a: FBcv:0007518 ! decreased efficacy of memory

[Term]
id: FBcv:0007525
name: increased efficacy of medium-term memory
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of medium-term memory (GO:0072375) relative to controls. 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).'" [FBC:CP, GOC:sart, PMID:14659098, PMID:7923375]
comment: This will usually be measured as an increased magnitude/rate of a behavioral output associated with medium-term memory formation.
is_a: FBcv:0007502 ! abnormal medium-term memory
is_a: FBcv:0007517 ! increased efficacy of memory

[Term]
id: FBcv:0007526
name: decreased efficacy of medium-term memory
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of medium-term memory (GO:0072375) relative to controls. 'medium-term memory' is defined as: 'The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).'" [FBC:CP, GOC:sart, PMID:14659098, PMID:7923375]
comment: This will usually be measured as a decreased magnitude/rate of a behavioral output associated with medium-term memory formation.
synonym: "reduced efficacy of medium-term memory" EXACT []
is_a: FBcv:0007502 ! abnormal medium-term memory
is_a: FBcv:0007518 ! decreased efficacy of memory

[Term]
id: FBcv:0007527
name: abnormal adult walking behavior
namespace: phenotypic_class
def: "Any abnormality in adult walking behavior (GO:0007628), which is defined as 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'." [GO:0007628, GOC:jid, GOC:pr, ISBN:0198606907]
is_a: FBcv:0007529 ! abnormal adult locomotory behavior

[Term]
id: FBcv:0007528
name: abnormal larval locomotory behavior
namespace: phenotypic_class
def: "Any abnormality in larval locomotory behavior (GO:0008345), which is defined as 'Locomotory behavior in a larval (immature) organism.'." [GO:0008345, GOC:ai]
is_a: FBcv:0000414 ! abnormal locomotor behavior

[Term]
id: FBcv:0007529
name: abnormal adult locomotory behavior
namespace: phenotypic_class
def: "Any abnormality in adult locomotory behavior (GO:0008344), which is defined as 'Locomotory behavior in a fully developed and mature organism.'." [GO:0008344, GOC:ai]
is_a: FBcv:0000414 ! abnormal locomotor behavior

[Term]
id: FBcv:0007530
name: increased efficacy of learning
namespace: phenotypic_class
def: "Phenotype that is an increase in the efficacy of learning (GO:0007612), relative to controls. 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.'" [ISBN:0582227089, ISBN:0721662544]
synonym: "improved learning" EXACT []
is_a: FBcv:0000397 ! abnormal learning

[Term]
id: FBcv:0007531
name: decreased efficacy of learning
namespace: phenotypic_class
def: "Phenotype that is a decrease in the efficacy of learning (GO:0007612), relative to controls. 'learning' is defined as: 'Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.'" [ISBN:0582227089, ISBN:0721662544]
synonym: "impaired learning" EXACT []
synonym: "reduced efficacy of learning" EXACT []
is_a: FBcv:0000397 ! abnormal learning

[Term]
id: FBcv:0007532
name: increased rate of chemosensory behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'." [GO:0007635, GOC:go_curators]
synonym: "increased rate of chemosensitive behavior" EXACT []
is_a: FBcv:0000403 ! abnormal chemosensory behavior

[Term]
id: FBcv:0007533
name: increased rate of proboscis extension reflex
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'." [FB:FBrf0044924, GO:0007637, GOC:jid]
is_a: FBcv:0000680 ! abnormal proboscis extension reflex
is_a: FBcv:0007532 ! increased rate of chemosensory behavior

[Term]
id: FBcv:0007534
name: increased rate of grooming behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'." [GO:0007625, GOC:jl, GOC:pr]
is_a: FBcv:0000420 ! abnormal grooming behavior

[Term]
id: FBcv:0007535
name: increased rate of locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'." [GO:0007626, GOC:dph]
is_a: FBcv:0000414 ! abnormal locomotor behavior

[Term]
id: FBcv:0007536
name: increased rate of adult walking behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of adult walking behavior (GO:0007628). 'adult walking behavior' is defined as: 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'." [GO:0007628, GOC:jid, GOC:pr, ISBN:0198606907]
is_a: FBcv:0007527 ! abnormal adult walking behavior
is_a: FBcv:0007538 ! increased rate of adult locomotory behavior

[Term]
id: FBcv:0007537
name: increased rate of larval locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of larval locomotory behavior (GO:0008345). 'larval locomotory behavior' is defined as: 'Locomotory behavior in a larval (immature) organism.'." [GO:0008345, GOC:ai]
is_a: FBcv:0007528 ! abnormal larval locomotory behavior
is_a: FBcv:0007535 ! increased rate of locomotory behavior

[Term]
id: FBcv:0007538
name: increased rate of adult locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of adult locomotory behavior (GO:0008344). 'adult locomotory behavior' is defined as: 'Locomotory behavior in a fully developed and mature organism.'." [GO:0008344, GOC:ai]
is_a: FBcv:0007529 ! abnormal adult locomotory behavior
is_a: FBcv:0007535 ! increased rate of locomotory behavior

[Term]
id: FBcv:0007539
name: increased rate of mating behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'." [GO:0007617, GOC:ai, GOC:dph]
is_a: FBcv:0000721 ! abnormal mating behavior

[Term]
id: FBcv:0007540
name: increased rate of courtship behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'." [GO:0007619, GOC:ai, GOC:dph]
is_a: FBcv:0000399 ! abnormal courtship behavior
is_a: FBcv:0007539 ! increased rate of mating behavior

[Term]
id: FBcv:0007541
name: increased rate of flight behavior
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of flight behavior (GO:0007629). 'flight behavior' is defined as: 'The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.'." [GO:0007629, GOC:jid, ISBN:0198606907]
is_a: FBcv:0007538 ! increased rate of adult locomotory behavior

[Term]
id: FBcv:0007542
name: increased rate of jump response
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of jump response (GO:0007630). 'jump response' is defined as: 'The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.'." [GO:0007630, GOC:jid, ISBN:0198606907]
is_a: FBcv:0000720 ! abnormal jump response
is_a: FBcv:0007538 ! increased rate of adult locomotory behavior

[Term]
id: FBcv:0007543
name: increased rate of copulation
namespace: phenotypic_class
def: "Phenotype that is an increase in any kind of rate (e.g. speed, frequency) of copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'." [GO:0007620, ISBN:0721662544]
is_a: FBcv:0006000 ! abnormal copulation
is_a: FBcv:0007539 ! increased rate of mating behavior

[Term]
id: FBcv:0007544
name: decreased rate of chemosensory behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of chemosensory behavior (GO:0007635). 'chemosensory behavior' is defined as: 'Behavior that is dependent upon the sensation of chemicals.'." [GO:0007635, GOC:go_curators]
synonym: "decreased rate of chemosensitive behavior" EXACT []
synonym: "reduced rate of chemosensory behavior" EXACT []
is_a: FBcv:0000403 ! abnormal chemosensory behavior

[Term]
id: FBcv:0007545
name: decreased rate of proboscis extension reflex
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of proboscis extension reflex (GO:0007637). 'proboscis extension reflex' is defined as: 'The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus.'." [FB:FBrf0044924, GO:0007637, GOC:jid]
synonym: "reduced rate of proboscis extension reflex" EXACT []
is_a: FBcv:0000680 ! abnormal proboscis extension reflex
is_a: FBcv:0007544 ! decreased rate of chemosensory behavior

[Term]
id: FBcv:0007546
name: decreased rate of grooming behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of grooming behavior (GO:0007625). 'grooming behavior' is defined as: 'The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.'." [GO:0007625, GOC:jl, GOC:pr]
synonym: "reduced rate of grooming behavior" EXACT []
is_a: FBcv:0000420 ! abnormal grooming behavior

[Term]
id: FBcv:0007547
name: decreased rate of locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of locomotory behavior (GO:0007626). 'locomotory behavior' is defined as: 'The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.'." [GO:0007626, GOC:dph]
synonym: "reduced rate of locomotory behavior" EXACT []
is_a: FBcv:0000414 ! abnormal locomotor behavior

[Term]
id: FBcv:0007548
name: decreased rate of adult walking behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of adult walking behavior (GO:0007628). 'adult walking behavior' is defined as: 'The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.'." [GO:0007628, GOC:jid, GOC:pr, ISBN:0198606907]
synonym: "reduced rate of adult walking behavior" EXACT []
is_a: FBcv:0007527 ! abnormal adult walking behavior
is_a: FBcv:0007550 ! decreased rate of adult locomotory behavior

[Term]
id: FBcv:0007549
name: decreased rate of larval locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of larval locomotory behavior (GO:0008345). 'larval locomotory behavior' is defined as: 'Locomotory behavior in a larval (immature) organism.'." [GO:0008345, GOC:ai]
synonym: "reduced rate of larval locomotory behavior" EXACT []
is_a: FBcv:0007528 ! abnormal larval locomotory behavior
is_a: FBcv:0007547 ! decreased rate of locomotory behavior

[Term]
id: FBcv:0007550
name: decreased rate of adult locomotory behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of adult locomotory behavior (GO:0008344). 'adult locomotory behavior' is defined as: 'Locomotory behavior in a fully developed and mature organism.'." [GO:0008344, GOC:ai]
synonym: "reduced rate of adult locomotory behavior" EXACT []
is_a: FBcv:0007529 ! abnormal adult locomotory behavior
is_a: FBcv:0007547 ! decreased rate of locomotory behavior

[Term]
id: FBcv:0007551
name: decreased rate of mating behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of mating behavior (GO:0007617). 'mating behavior' is defined as: 'The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.'." [GO:0007617, GOC:ai, GOC:dph]
synonym: "reduced rate of mating behavior" EXACT []
is_a: FBcv:0000721 ! abnormal mating behavior

[Term]
id: FBcv:0007552
name: decreased rate of courtship behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of courtship behavior (GO:0007619). 'courtship behavior' is defined as: 'The behavior of an organism for the purpose of attracting sexual partners.'." [GO:0007619, GOC:ai, GOC:dph]
synonym: "reduced rate of courtship behavior" EXACT []
is_a: FBcv:0000399 ! abnormal courtship behavior
is_a: FBcv:0007551 ! decreased rate of mating behavior

[Term]
id: FBcv:0007553
name: decreased rate of flight behavior
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of flight behavior (GO:0007629). 'flight behavior' is defined as: 'The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.'." [GO:0007629, GOC:jid, ISBN:0198606907]
synonym: "reduced rate of flight behavior" EXACT []
is_a: FBcv:0007550 ! decreased rate of adult locomotory behavior

[Term]
id: FBcv:0007554
name: decreased rate of jump response
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of jump response (GO:0007630). 'jump response' is defined as: 'The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.'." [GO:0007630, GOC:jid, ISBN:0198606907]
synonym: "reduced rate of jump response" EXACT []
is_a: FBcv:0000720 ! abnormal jump response
is_a: FBcv:0007550 ! decreased rate of adult locomotory behavior

[Term]
id: FBcv:0007555
name: decreased rate of copulation
namespace: phenotypic_class
def: "Phenotype that is a decrease in any kind of rate (e.g. speed, frequency) of copulation (GO:0007620). 'copulation' is defined as: 'The act of sexual union between male and female, involving the transfer of sperm.'." [GO:0007620, ISBN:0721662544]
synonym: "reduced rate of copulation" EXACT []
is_a: FBcv:0006000 ! abnormal copulation
is_a: FBcv:0007551 ! decreased rate of mating behavior

[Term]
id: FBcv:0009000
name: single-cell RNA-Seq
namespace: assay_type
def: "A method for quantifying the transcriptome of individual cells, in which transcripts isolated from single cells are subjected to high-throughput sequencing and mapping to a reference genome." [PMID:28821273]
synonym: "scRNA-Seq" EXACT [PMID:32405060]
synonym: "single-cell RNA sequencing assay" EXACT []
xref: EFO:0008913
xref: OBI:0002631
is_a: FBcv:0003068 ! RNA-Seq

[Term]
id: FBcv:0009001
name: single-nucleus RNA-Seq
namespace: assay_type
def: "A method for quantifying the transcriptome of individual cells, in which transcripts isolated from single nuclei are subjected to high-throughput sequencing and mapping to a reference genome." [PMID:28821273]
synonym: "single-nucleus RNA sequencing assay" EXACT []
synonym: "snRNA-Seq" EXACT [PMID:32405060]
xref: EFO:0009809
is_a: FBcv:0009000 ! single-cell RNA-Seq

[Term]
id: FBcv:0009002
name: cell clustering analysis
namespace: result_type
def: "A result that groups individual cells into populations sharing a similar transcriptional profile." [PMID:28821273]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0009003
name: transcriptional cell cluster
namespace: result_type
def: "A result that represents a population of cells sharing a similar transcriptional profile." [PMID:28821273]
is_a: FBcv:0003082 ! result type

[Term]
id: FBcv:0009004
name: isolated nuclei
namespace: biosample_type
def: "A biosample containing dissociated cell nuclei isolated from the organism." [FBC:DPG]
is_a: FBcv:0003044 ! biosample type

[Term]
id: FBcv:0009005
name: single-cell library sequencing
namespace: assay_attribute
def: "A method to prepare and sequence a library of cDNAs obtained from single cells." [FBC:DPG]
is_a: FBcv:0003208 ! assay method

[Term]
id: FBcv:0009006
name: DROP-Seq
namespace: assay_attribute
def: "A method that uses the DROP-Seq platform (Macosko et al., 2015) to prepare and sequence a cDNA library." [PMID:26000488]
is_a: FBcv:0009005 ! single-cell library sequencing

[Term]
id: FBcv:0009007
name: Smart-seq2
namespace: assay_attribute
def: "A method that uses the Smart-seq2 platform (Picelli et al., 2013) to prepare and sequence a cDNA library." [PMID:24056875]
is_a: FBcv:0009005 ! single-cell library sequencing

[Term]
id: FBcv:0009008
name: 10x sequencing
namespace: assay_attribute
def: "A method that uses the Chromium platform from 10x Genomics to prepare and sequence a cDNA library." [PMID:29126257]
is_a: FBcv:0009005 ! single-cell library sequencing

[Term]
id: FBcv:0009009
name: starvation
namespace: biosample_attribute
def: "A sample in which individuals have been deprived of food." [FBC:DPG]
is_a: FBcv:0003146 ! growth condition

[Term]
id: FBcv:0009010
name: cell dissociation
namespace: biosample_attribute
def: "A sample in which a biological specimen has been separated into individual cells." [EFO:0009091]
xref: EFO:0009091
is_a: FBcv:0009015 ! biosample preparation method

[Term]
id: FBcv:0009011
name: mechanical cell dissociation
namespace: biosample_attribute
def: "A sample in which a biological specimen has been separated into individual cells by applying mechanical forces." [EFO:0009129]
xref: EFO:0009129
is_a: FBcv:0009010 ! cell dissociation

[Term]
id: FBcv:0009012
name: enzymatic cell dissociation
namespace: biosample_attribute
def: "A sample in which a biological specimen has been separated into individual cells by using enzymes." [EFO:0009128]
xref: EFO:0009128
is_a: FBcv:0009010 ! cell dissociation

[Term]
id: FBcv:0009013
name: chemical cell dissociation
namespace: biosample_attribute
def: "A sample in which a biological specimen has been separated into individual cells by using non-enzymatic chemicals." [EFO:0011026]
xref: EFO:0011026
is_a: FBcv:0009010 ! cell dissociation

[Term]
id: FBcv:0009014
name: biosample treatment method
namespace: biosample_attribute
def: "Experimental treatment method that a biosample has been subjected to." [FBC:DPG]
is_a: FBcv:0003164 ! biosample method

[Term]
id: FBcv:0009015
name: biosample preparation method
namespace: biosample_attribute
def: "Method pertaining to the collection or isolation of a biosample." [FBC:DPG]
is_a: FBcv:0003164 ! biosample method

[Term]
id: FBcv:0009016
name: conditional degradation tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the gene product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product being targeted for degradation, where this property can be regulated in response to a particular stimulus." [FBC:GM]
synonym: "conditional gene product degradation tag" EXACT []
is_a: FBcv:0005042 ! degradation tag

[Term]
id: FBcv:0009017
name: cell type-specific gene expression profile
namespace: result_type
def: "A result that provides the expression values for all (or some subset of) genes in a given biological sample containing cells of a single cell type." [FBC:DPG]
is_a: FBcv:0003088 ! gene expression profile

[Term]
id: FBcv:0009018
name: cell type-specific RNA-sequencing analysis
namespace: result_type
def: "An analysis that results from the sequencing of RNAs from multiple highly purified samples." [FBC:DPG]
is_a: FBcv:0003108 ! analysis

[Term]
id: FBcv:0009019
name: INTACT nuclei isolation
namespace: biosample_attribute
def: "Nuclei of a single cell type have been isolated with the INTACT (Isolation of Nuclei TAgged in a specific Cell Type) strategy (Henry et al., 2012)." [FlyBase:FBrf0219710]
is_a: FBcv:0003170 ! cell isolation

[Term]
id: FBcv:0009020
name: TAPIN nuclei isolation
namespace: biosample_attribute
def: "Nuclei of a single cell type have been isolated with the TAPIN (Tandem Affinity Purification of Intact Nuclei) strategy (Davis et al., 2020)." [FlyBase:FBrf0244935]
synonym: "TAPIN-seq" BROAD [FlyBase:FBrf0244935]
is_a: FBcv:0003170 ! cell isolation

[Term]
id: FBcv:0009021
name: nuclear RNA isolation
namespace: assay_attribute
def: "Material that is derived from the isolation of RNA from nuclei." [FBC:DPG]
is_a: FBcv:0003176 ! assay material

[Term]
id: FBcv:0009022
name: gene product engineering tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of a transgenic locus or modified endogenous locus and which can be used to modify a gene product of interest in a defined manner." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0009023
name: protease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of a peptide bond." [GO:0008233]
subset: common_tool_use
synonym: "peptidase" EXACT [FBC:GM]
is_a: FBcv:0009022 ! gene product engineering tool

[Term]
id: FBcv:0009024
name: protease target site
namespace: experimental_tool_descriptor
def: "A recognition site for a protease, an enzyme that catalyzes hydrolysis of a peptide bond." [FBC:GM]
is_a: FBcv:0005057 ! protein cleavage tag

[Term]
id: FBcv:0009025
name: driver-specific gene expression profile
namespace: result_type
def: "A result that provides the expression values for all (or some subset of) genes in a given biological sample obtained using a specific transcriptional driver (or combination of drivers), when that driver is not associated to a clearly identified cell type." [FBC:DPG]
is_a: FBcv:0003088 ! gene expression profile

[Term]
id: FBcv:0009026
name: split system combination
namespace: experimental_tool_descriptor
def: "A combination of two or more 'split system components' that together reconstitute a functional experimental tool." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0009027
name: split driver fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, for example by including a compatible physical interaction domain or split intein fragment in each of the complementary split driver fragments." [FBC:GM]
is_a: FBcv:0005051 ! split system component

[Term]
id: FBcv:0009028
name: conditional split driver fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0009027 ! split driver fragment

[Term]
id: FBcv:0009029
name: light-regulated split driver fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0009028 ! conditional split driver fragment

[Term]
id: FBcv:0009030
name: small molecule-regulated split driver fragment
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a transcriptional activator ('driver') that can be used to reconstitute a functional transcription driver when brought together in vivo with a complementary split driver fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
synonym: "small-molecule regulated split driver fragment" EXACT []
is_a: FBcv:0009028 ! conditional split driver fragment

[Term]
id: FBcv:0009031
name: split protease
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a protease. A functional protease can be reconstituted when complementary split protease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0009046 ! split gene product engineering tool

[Term]
id: FBcv:0009032
name: split bioluminescence reporter
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a bioluminescence reporter. A functional bioluminescence reporter can be reconstituted when complementary split bioluminescence reporter fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0005053 ! split reporter enzyme

[Term]
id: FBcv:0009033
name: conditional split protease
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a protease that can be used to reconstitute a functional protease when brought together in vivo with a complementary split protease fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0009031 ! split protease

[Term]
id: FBcv:0009034
name: light-regulated split protease
namespace: experimental_tool_descriptor
def: "Catalytically inactive fragment of a protease that can be used to reconstitute a functional protease when brought together in vivo with a complementary split protease fragment, where the process that brings the complementary fragments together can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0009033 ! conditional split protease

[Term]
id: FBcv:0009035
name: split cell ablation tool
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a cell ablation tool. A functional cell ablation tool can be reconstituted when complementary split cell ablation tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0009049 ! split cell viability regulation tool

[Term]
id: FBcv:0009036
name: conditional protease target site
namespace: experimental_tool_descriptor
def: "A peptide sequence that can act as a recognition site for a protease (an enzyme that catalyzes hydrolysis of a peptide bond), where this property can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0009024 ! protease target site

[Term]
id: FBcv:0009037
name: light-regulated protease target site
namespace: experimental_tool_descriptor
def: "A peptide sequence that can act as a recognition site for a protease (an enzyme that catalyzes hydrolysis of a peptide bond), where this property can be regulated by irradiation with a pulse of light." [FBC:GM]
is_a: FBcv:0009036 ! conditional protease target site

[Term]
id: FBcv:0009038
name: conditional RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0005078 ! RNA-guided nuclease

[Term]
id: FBcv:0009039
name: small molecule-regulated RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "An enzyme that catalyzes hydrolysis of DNA in a site-specific manner, where the specificity is determined by a guide RNA that contains sequence complementary to the DNA sequence of interest (rather than being an inherent property of the nuclease itself) and where the nuclease activity can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0009038 ! conditional RNA-guided nuclease

[Term]
id: FBcv:0009040
name: protein splicing tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing." [FBC:GM]
is_a: FBcv:0009022 ! gene product engineering tool

[Term]
id: FBcv:0009041
name: conditional protein splicing tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing, where this process can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0009040 ! protein splicing tag

[Term]
id: FBcv:0009042
name: small molecule-regulated protein splicing tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and which results in the tagged gene product undergoing protein splicing, where this process can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0009041 ! conditional protein splicing tag

[Term]
id: FBcv:0009043
name: cell viability regulation tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to regulate the viability of a specific cell or anatomical structure." [FBC:GM]
is_a: FBcv:0005001 ! experimental tool descriptor

[Term]
id: FBcv:0009044
name: cell death inhibition tool
namespace: experimental_tool_descriptor
def: "Sequence that forms all or part of the gene product encoded by a transgenic locus or modified endogenous locus and that confers a specific property used to inhibit cell death in a specific cell or anatomical structure." [FBC:GM]
is_a: FBcv:0009043 ! cell viability regulation tool

[Term]
id: FBcv:0009045
name: split genome engineering tool
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a genome engineering tool. A functional genome engineering tool can be reconstituted when complementary split genome engineering tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0005051 ! split system component

[Term]
id: FBcv:0009046
name: split gene product engineering tool
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a gene product engineering tool. A functional gene product engineering tool can be reconstituted when complementary split gene product engineering tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0005051 ! split system component

[Term]
id: FBcv:0009047
name: split gene product detection tool
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a gene product detection tool. A functional gene product detection tool can be reconstituted when complementary split gene product detection tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0005051 ! split system component

[Term]
id: FBcv:0009048
name: split protein detection tool
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a protein detection tool. A functional protein detection tool can be reconstituted when complementary split protein detection tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0009047 ! split gene product detection tool

[Term]
id: FBcv:0009049
name: split cell viability regulation tool
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a cell viability regulation tool. A functional cell viability regulation tool can be reconstituted when complementary split cell viability regulation tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0005051 ! split system component

[Term]
id: FBcv:0009050
name: split nuclease
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a nuclease. A functional nuclease can be reconstituted when complementary split nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0009045 ! split genome engineering tool

[Term]
id: FBcv:0009051
name: split RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "Non-functional fragment of an RNA-guided nuclease. A functional RNA-guided nuclease can be reconstituted when complementary split RNA-guided nuclease fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0009050 ! split nuclease

[Term]
id: FBcv:0009052
name: conditional split RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated in response to a particular stimulus." [FBC:GM]
is_a: FBcv:0009051 ! split RNA-guided nuclease

[Term]
id: FBcv:0009053
name: small molecule-regulated split RNA-guided nuclease
namespace: experimental_tool_descriptor
def: "Non-functional fragment of an RNA-guided nuclease that can be used to reconstitute a functional RNA-guided nuclease when brought together in vivo with a complementary split RNA-guided nuclease fragment, where the process that brings the complementary fragments together can be regulated by binding to a small molecule, such as an ion or ligand." [FBC:GM]
is_a: FBcv:0009052 ! conditional split RNA-guided nuclease

[Term]
id: FBcv:0009054
name: split protein splicing tag
namespace: experimental_tool_descriptor
def: "Sequence that forms part of the protein product encoded by a transgenic locus or modified endogenous locus and that can catalyze protein splicing when brought together with a complementary split protein splicing tag in vivo. Typically used to join two separate protein sequences by trans-splicing; in this case the two separate protein sequences are each initially tagged with one half of a pair of complementary split protein splicing tags. Alternatively, if both halves of a pair of complementary split protein splicing tags are used to tag each end of a single protein sequence, they can be used to generate a cyclized protein molecule." [FBC:GM]
is_a: FBcv:0009046 ! split gene product engineering tool

[Term]
id: FBcv:0009055
name: split specific binding tool
namespace: experimental_tool_descriptor
def: "Non-functional fragment of a specific binding tool. A functional specific binding tool can be reconstituted when complementary split specific binding tool fragments are brought together in vivo, for example by fusing the fragments to peptides that physically interact." [FBC:GM]
is_a: FBcv:0005051 ! split system component

[Term]
id: FBcv:0010000
name: obsolete living stock
comment: Consider - FBsv:0000002.
is_obsolete: true

[Term]
id: FBcv:0010001
name: obsolete molecular extract
comment: Consider - FBsv:0000003.
is_obsolete: true

[Term]
id: FBcv:0010002
name: obsolete preserved specimen
comment: Consider - FBsv:0000005.
is_obsolete: true

[Term]
id: FBcv:0010003
name: obsolete E cytotype stock
is_obsolete: true

[Term]
id: FBcv:0010004
name: obsolete M cytotype stock
is_obsolete: true

[Term]
id: FBcv:0010005
name: obsolete genomic DNA
comment: Consider - FBsv:0000004.
is_obsolete: true

[Term]
id: FBcv:0010006
name: obsolete ethanol-preserved specimen
comment: Consider - FBsv:0000007.
is_obsolete: true

[Term]
id: FBcv:0010007
name: obsolete pinned specimen
is_obsolete: true

[Term]
id: FBcv:0010009
name: obsolete fluorescent balancer
comment: Consider - FBsv:0001010.
is_obsolete: true

[Term]
id: FBcv:0010010
name: obsolete lacZ balancer
comment: Consider - FBsv:0001011.
is_obsolete: true

[Term]
id: FBcv:0010011
name: obsolete laboratory wild-type stock
is_obsolete: true

[Term]
id: FBcv:0010012
name: obsolete collection
comment: Consider - FBsv:0000100.
is_obsolete: true

[Term]
id: FBcv:0010013
name: obsolete stock center collection
comment: Consider - FBsv:0000101.
is_obsolete: true

[Term]
id: FBcv:0010014
name: obsolete laboratory collection
comment: Consider - FBsv:0000102.
is_obsolete: true

[Term]
id: FBcv:0010015
name: obsolete Saxton laboratory
is_obsolete: true

[Term]
id: FBcv:0010016
name: obsolete Garcia-Bellido laboratory
comment: Consider - FBsv:0000109.
is_obsolete: true

[Term]
id: FBcv:0010017
name: obsolete Nusslein-Volhard laboratory
comment: Consider - FBsv:0000108.
is_obsolete: true

[Term]
id: FBcv:0010018
name: obsolete Carpenter laboratory
comment: Consider - FBsv:0000110.
is_obsolete: true

[Term]
id: FBcv:0010019
name: obsolete Artavanis laboratory
synonym: "Harvard Medical School Exelixis Drosophila Collection" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010020
name: obsolete Exelixis Drosophila Stock Collection at Harvard Medical School
comment: Consider - FBsv:0000105.
synonym: "Artavanis-Tsakonas laboratory" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010021
name: obsolete Bloomington Drosophila Stock Center
comment: Consider - FBsv:0000103.
synonym: "BDSC" RELATED []
synonym: "Bloomington" EXACT []
synonym: "BSC" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010022
name: obsolete San Diego Drosophila Species Stock Center
comment: Consider - FBsv:0000106.
synonym: "Drosophila species stock center" RELATED []
synonym: "species stock center" EXACT []
synonym: "Tucson" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010023
name: obsolete Szeged Drosophila Stock Centre
synonym: "Szeged" RELATED []
is_obsolete: true

[Term]
id: FBcv:0010024
name: obsolete Drosophila Genetic Resource Center
comment: Consider - FBsv:0000104.
synonym: "DGRC" RELATED []
synonym: "Kyoto" RELATED []
synonym: "Kyoto stock center" RELATED []
is_obsolete: true

[Typedef]
id: conditionality
name: conditionality