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fbdv-edit.obo
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format-version: 1.2
data-version: 2016-10-14
subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation"
subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation"
subsetdef: goslim_aspergillus "Aspergillus GO slim"
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_ChEMBL "ChEMBL GO slim"
subsetdef: goslim_chembl "ChEMBL GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_metagenomics "Metagenomics GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
default-namespace: FlyBase_development_CV
namespace-id-rule: * FBdv:$sequence(8,7000,10000)$
import: http://purl.obolibrary.org/obo/fbdv/imports/merged_import.owl
import: http://purl.obolibrary.org/obo/fbdv/patterns/definitions.owl
ontology: fbdv
property_value: http://purl.org/dc/elements/1.1/creator "http://orcid.org/0000-0002-1373-1705" xsd:string
property_value: http://purl.org/dc/elements/1.1/creator "http://orcid.org/0000-0002-7073-9172" xsd:string
property_value: http://purl.org/dc/elements/1.1/creator "https://orcid.org/0000-0001-5948-3092" xsd:string
property_value: http://purl.org/dc/elements/1.1/creator "https://orcid.org/0000-0002-0027-0858" xsd:string
property_value: http://purl.org/dc/elements/1.1/description "An ontology of Drosophila melanogaster developmental stages." xsd:string
property_value: http://purl.org/dc/elements/1.1/title "Drosophila Developmental Ontology" xsd:string
property_value: http://purl.org/dc/terms/license "https://creativecommons.org/licenses/by/4.0/" xsd:string
property_value: IAO:0000700 FBdv:00000000
property_value: IAO:0000700 FBdv:00005259
property_value: IAO:0000700 FBdv:00007013
property_value: IAO:0000700 FBdv:00007024
[Term]
id: FBdv:00000000
name: Drosophila life
alt_id: FBdv_root:00000000
def: "The life of an individual of the species Drosophila melanogaster, from fertilization to death." [FBC:DOS]
synonym: "Drosophila life cycle" EXACT []
is_a: BFO:0000003 ! occurrent
[Term]
id: FBdv:00000054
name: cleavage stage
def: "Stage during which the nucleus of the fertilized egg performs 13 rapid divisions, prior to cellularization (Hartenstein, 1993; Campos-Ortega and Hartenstein, 1997). The first seven divisions are synchronous (Campos-Ortega and Hartenstein, 1997). During the course of the subsequent three divisions, most of the nuclei approach the surface and then divide asynchronously a further three times, bringing the total number of cells to around 5000 (Campos-Ortega and Hartenstein, 1997). This corresponds to embryonic stages 1-4 (Hartenstein, 1993)." [FlyBase:FBrf0064803, FlyBase:FBrf0089570]
comment: Temporal ordering number - 25.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00005288 ! immediately preceded by fertilized egg stage
[Term]
id: FBdv:00004450
name: late extended germ band stage
def: "A collective term for stages 11 and 12." [FBC:DOS]
comment: Temporal ordering number - 300.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005321 ! substage of extended germ band stage
relationship: RO:0002087 FBdv:00005324 ! immediately preceded by embryonic stage 10
relationship: RO:0002087 FBdv:00014201 ! immediately preceded by early extended germ band stage
[Term]
id: FBdv:00004886
name: oogenesis
def: "The complete process of formation and maturation of an ovum or female gemate from a primordial female germ cell." [GO:0048477]
comment: Temporal ordering number - 10000.
synonym: "oogenesis stage" EXACT []
xref: GO:0048477
is_a: FBdv:00007009 ! developmental process
[Term]
id: FBdv:00005259
name: developmental stage
alt_id: FBdv:00007010
def: "A temporal subdivision of a developmental process." [FBC:DOS]
is_a: BFO:0000003 ! occurrent
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2009-10-01T05:56:56Z" xsd:string
[Term]
id: FBdv:00005261
name: oogenesis stage S1
def: "Earliest stage of ovarian cyst development - lasts while the 16 cell cyst is within the germarium (region 3)." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10010.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
[Term]
id: FBdv:00005262
name: oogenesis stage S2
def: "Oogenesis stage that begins when the cyst leaves the germarium (from this point the cyst is referred to as an egg chamber). During this stage, polyploidation of the nurse cells begins, they reach a ploidy of 8C, and follicle cells start to divide." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10020.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005261 ! immediately preceded by oogenesis stage S1
[Term]
id: FBdv:00005263
name: oogenesis stage S3
def: "Oogenesis stage that begins when the oocyte chromosomes condense into a karyosome attached to a distinctive spherical structure known as an endobody. The oocyte nucleolus disappears completely. During this stage, nurse cell ploidy reaches 16C." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10030.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005262 ! immediately preceded by oogenesis stage S2
[Term]
id: FBdv:00005264
name: oogenesis stage S4
def: "Oogenesis stage that begins when the nurse cells chromosomes become bulbous. Nurse cell chromosomes during this stage are polytene and reach a ploidy of 32C. The egg chamber is oval shaped." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10040.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005263 ! immediately preceded by oogenesis stage S3
[Term]
id: FBdv:00005265
name: oogenesis stage S5
def: "Oogenesis stage that begins when nurse cell chromosomes are no longer bulbous - the association between homologs weakens so that these chromosomes no longer have a polytene structure. During this stage, posterior nurse cell nuclei have a higher ploidy (64C) than anterior ones." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10050.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005264 ! immediately preceded by oogenesis stage S4
[Term]
id: FBdv:00005266
name: oogenesis stage S6
def: "Oogenesis stage during which follicle cell division ceases." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10060.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005265 ! immediately preceded by oogenesis stage S5
[Term]
id: FBdv:00005267
name: oogenesis stage S7
def: "Oogenesis stage during which polyploidation and enlargement of follicle cells begins. Nurse cell ploidy ranges from 256C (anterior) to 512C (posterior) and the egg chamber gains an elongated shape." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10070.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005266 ! immediately preceded by oogenesis stage S6
[Term]
id: FBdv:00005268
name: oogenesis stage S8
def: "Oogenesis stage which begins when yolk first appears in the oocyte. Follicle cell migration over the oocyte begins during this stage (although mostly occurs during stage 9)." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10080.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005267 ! immediately preceded by oogenesis stage S7
[Term]
id: FBdv:00005269
name: oogenesis stage S9
def: "Oogenesis stage that begins when the border cells begin to migrate. During this stage: the oocyte is about 1/3 the length of the egg chamber with its nucleus located antero-dorsally; follicle cell migration results in an anterior to posterior gradient of follicle cell thickness with posterior cells being thicker (-> columnar) and posterior cells thinner ( -> squamous); border cell migration begins and ends; secretion of vitelline membrane begins." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10090.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005268 ! immediately preceded by oogenesis stage S8
[Term]
id: FBdv:00005270
name: oogenesis stage S10
def: "Oogenesis stage that begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends with the beginning of nurse cell dumping." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10100.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005269 ! immediately preceded by oogenesis stage S9
[Term]
id: FBdv:00005271
name: oogenesis stage S10A
def: "Oogenesis stage which begins when all the oocyte associated follicular epithelium is columnar and all of the nurse cell associated follicular epithelium is completely squamous and ends when centripetal follicle migration begins. During this stage, the migrating border cells reach the oocyte. The oocyte is about 50% egg chamber length." [FlyBase:FBrf0021038, FlyBase:FBrf0034074]
comment: Temporal ordering number - 10110.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005270 ! substage of oogenesis stage S10
relationship: RO:0002087 FBdv:00005269 ! immediately preceded by oogenesis stage S9
[Term]
id: FBdv:00005272
name: oogenesis stage S10B
def: "Oogenesis stage that begins when the centripetal follicle cells begin to migrate. As a result, the vitelline membrane extends into the opercular region. This stage ends when nurse cell dumping begins." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10120.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005270 ! substage of oogenesis stage S10
relationship: RO:0002087 FBdv:00005271 ! immediately preceded by oogenesis stage S10A
[Term]
id: FBdv:00005273
name: oogenesis stage S11
def: "Oogenesis stage that begins when nurse cell dumping begins and development of the wax layer begins. The dorsal appendages begin to form during this stage. This stage ends when dying nurse cells form an anterior cap to the oocyte." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0043885, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10130.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005270 ! immediately preceded by oogenesis stage S10
relationship: RO:0002087 FBdv:00005272 ! immediately preceded by oogenesis stage S10B
[Term]
id: FBdv:00005274
name: oogenesis stage S12
def: "Oogenesis stage that begins when dying nurse cells form an anterior cap to the oocyte. Shortly after this, nurse cell dumping and growth of the oocyte are complete. Elongation of the dorsal appendages and formation of the innermost chorionic layer and endochorion begins during this stage." [FlyBase:FBrf0021038, FlyBase:FBrf0034074, FlyBase:FBrf0043885, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10160.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005273 ! immediately preceded by oogenesis stage S11
[Term]
id: FBdv:00005275
name: oogenesis stage S12A
def: "Innermost chorionic layer and endochorion begin to form in the anterior of the follicle." [FlyBase:FBrf0043885]
comment: Temporal ordering number - 10170.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005274 ! substage of oogenesis stage S12
relationship: RO:0002087 FBdv:00005273 ! immediately preceded by oogenesis stage S11
[Term]
id: FBdv:00005276
name: oogenesis stage S12B
def: "Secretion of innermost chorionic layer and endochorion begins in the main follicle cells." [FlyBase:FBrf0043885]
comment: Temporal ordering number - 10180.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005274 ! substage of oogenesis stage S12
relationship: RO:0002087 FBdv:00005275 ! immediately preceded by oogenesis stage S12A
[Term]
id: FBdv:00005277
name: oogenesis stage S12C
def: "Formation of specialized endochorion structures in the anterior of the follicle: branches in the developing dorsal appendages; compact endochorion lacking the pillars seen in the rest of the follicle." [FlyBase:FBrf0021038]
comment: Temporal ordering number - 10190.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005274 ! substage of oogenesis stage S12
relationship: RO:0002087 FBdv:00005276 ! immediately preceded by oogenesis stage S12B
[Term]
id: FBdv:00005278
name: oogenesis stage S13
def: "Oogenesis stage that begins when the micropyle begins to form. At the beginning of this stage, about 12-15 nurse cell nuclei remain at the anterior of the oocyte. By the end of this stage, none of these nuclei remain. Oocyte meiosis up to arrest at full metaphase I occurs during this stage." [FlyBase:FBrf0021038, FlyBase:FBrf0029744, FlyBase:FBrf0034074, FlyBase:FBrf0064777]
comment: Temporal ordering number - 10200.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005274 ! immediately preceded by oogenesis stage S12
relationship: RO:0002087 FBdv:00005277 ! immediately preceded by oogenesis stage S12C
[Term]
id: FBdv:00005279
name: oogenesis stage S13A
def: "Oogenesis stage during which 12-15 nurse cell nuclei remain at the anterior of the oocyte. At this stage, the oocyte nucleus has reached its maximum volume and its chromosomes are compressed into a 5-7 micrometer karyosome." [FlyBase:FBrf0029744]
comment: Temporal ordering number - 10210. An alternative division of stage 13 into two sub-stages, A and B, has been defined on the basis of chorion development (see FBrf0043885). This ontology uses an alternative subdivision based on nurse cell nucleus number and oocyte meiosis, as the former at least, is easier to score than chorion ultrastructure.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005278 ! substage of oogenesis stage S13
relationship: RO:0002087 FBdv:00005277 ! immediately preceded by oogenesis stage S12C
[Term]
id: FBdv:00005280
name: oogenesis stage S13B
def: "Oogenesis stage during which 9-11 nurse cell nuclei remain at the anterior of the oocyte. During this stage, the nuclear membrane of the oocyte nucleus disappears, indicating the start of meiotic pro-metaphase." [FlyBase:FBrf0029744]
comment: Temporal ordering number - 10220. An alternative division of stage 13 into two sub-stages, A and B, has been defined on the basis of chorion development (see FBrf0043885). This ontology uses an alternative subdivision based on nurse cell nucleus number and oocyte meiosis, as the former at least, is easier to score than chorion ultrastructure.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005278 ! substage of oogenesis stage S13
relationship: RO:0002087 FBdv:00005279 ! immediately preceded by oogenesis stage S13A
[Term]
id: FBdv:00005281
name: oogenesis stage S13C
def: "Oogenesis stage during which only 7-8 nurse cell nuclei remain at the anterior of the oocyte. At the beginning of this stage, oocyte chromosome bivalents separate from each other - indicating mid-prometaphase of oocyte meiosis." [FlyBase:FBrf0029744]
comment: Temporal ordering number - 10230.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005278 ! substage of oogenesis stage S13
relationship: RO:0002087 FBdv:00005280 ! immediately preceded by oogenesis stage S13B
[Term]
id: FBdv:00005282
name: oogenesis stage S13D
def: "Oogenesis stage during which only 5-6 nurse cell nuclei remain at the anterior of the oocyte. The oocyte nucleus is in late prometaphase:the bivalents arrange themselves in on the equatorial plane of the spindle; homologous centromeres are pulled towards the poles." [FlyBase:FBrf0029744]
comment: Temporal ordering number - 10240.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005278 ! substage of oogenesis stage S13
relationship: RO:0002087 FBdv:00005281 ! immediately preceded by oogenesis stage S13C
[Term]
id: FBdv:00005283
name: oogenesis stage S14
def: "The last stage of oogenesis. This stage begins when no nurse cell nuclei remain at the anterior of the egg (chamber). Exochorion formation and secretion occurs during this stage. The dorsal appendages complete their elongation and the follicle cells die." [FlyBase:FBrf0043885]
comment: Temporal ordering number - 10260.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004886 ! substage of oogenesis
relationship: RO:0002087 FBdv:00005278 ! immediately preceded by oogenesis stage S13
relationship: RO:0002087 FBdv:00005282 ! immediately preceded by oogenesis stage S13D
[Term]
id: FBdv:00005284
name: oogenesis stage S14A
def: "Secretion and formation of the outer endochorionic network by throughout the follicle. Crystallization of the innermost chorionic layer of the main body follicle cells." [FlyBase:FBrf0021038, FlyBase:FBrf0043885]
comment: Temporal ordering number - 10270.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005283 ! substage of oogenesis stage S14
relationship: RO:0002087 FBdv:00005282 ! immediately preceded by oogenesis stage S13D
[Term]
id: FBdv:00005285
name: oogenesis stage S14B
def: "Secretion of the exochorion begins and ends." [FlyBase:FBrf0021038, FlyBase:FBrf0043885]
comment: Temporal ordering number - 10280.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005283 ! substage of oogenesis stage S14
relationship: RO:0002087 FBdv:00005284 ! immediately preceded by oogenesis stage S14A
[Term]
id: FBdv:00005286
name: egg stage
def: "The stage of the Drosophila life-cycle from maturation of an egg to the end of fertilization. At the beginning of this stage, the nucleus is arrested in meiotic metaphase I. The completion of meiosis and the start of protein synthesis are triggered by ovulation. If the female has already mated, fertilization begins during meiosis." [FlyBase:FBrf0064779]
comment: Temporal ordering number - 10290.
is_a: FBdv:00005259 ! developmental stage
[Term]
id: FBdv:00005287
name: unfertilized egg stage
def: "Developmental stage that starts with ovulation, at the end of oogenesis, until the egg is fertilized by a sperm." [FlyBase:FBrf0158848]
comment: Temporal ordering number - 10300.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005286 ! substage of egg stage
relationship: RO:0002087 FBdv:00005283 ! immediately preceded by oogenesis stage S14
relationship: RO:0002087 FBdv:00005285 ! immediately preceded by oogenesis stage S14B
[Term]
id: FBdv:00005288
name: fertilized egg stage
def: "Developmental stage that starts with sperm entry until the first mitotic division of the zygote." [FlyBase:FBrf0229233]
comment: Temporal ordering number - 10.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005286 ! substage of egg stage
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00005287 ! immediately preceded by unfertilized egg stage
[Term]
id: FBdv:00005289
name: embryonic stage
def: "Life stage that begins with a fertilized egg, and finishes with hatching at the end of embryonic stage 17 (Campos-Ortega and Hartenstein, 1997)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 20.
is_a: FBdv:00007012 ! life stage
relationship: RO:0002087 FBdv:00005287 ! immediately preceded by unfertilized egg stage
relationship: RO:0002090 FBdv:00005336 ! immediately precedes larval stage
relationship: RO:0002090 FBdv:00005337 ! immediately precedes first instar larval stage
[Term]
id: FBdv:00005290
name: pre-blastoderm stage
def: "Stage prior to the formation of the syncitial blastoderm, including the first 9 cell divisions and the migration of nuclei to the periphery (cortex) of the embryo (Foe and Alberts, 1983; Jaeger et al., 2012). This lasts from fertilization to embryonic stage 3 (Campos-Ortega and Hartenstein, 1997)." [FlyBase:FBrf0039741, FlyBase:FBrf0089570, FlyBase:FBrf0220623]
comment: Temporal ordering number - 30.
synonym: "pre-blastoderm" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00000054 ! substage of cleavage stage
relationship: RO:0002087 FBdv:00005288 ! immediately preceded by fertilized egg stage
[Term]
id: FBdv:00005291
name: embryonic stage 1
def: "The embryonic stage that lasts from the end of fertilization to the end of the second nuclear division. Duration at 25 degrees C: approximately 25 minutes (0-25 minutes after egg laying)." [FlyBase:FBrf0064779, FlyBase:FBrf0089570]
comment: Temporal ordering number - 40.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005290 ! substage of pre-blastoderm stage
relationship: RO:0002087 FBdv:00005288 ! immediately preceded by fertilized egg stage
[Term]
id: FBdv:00005292
name: embryonic cycle 1
def: "The first mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 50.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005291 ! substage of embryonic stage 1
relationship: RO:0002087 FBdv:00005288 ! immediately preceded by fertilized egg stage
[Term]
id: FBdv:00005293
name: embryonic stage 2
def: "Nuclear divisions 3-8. The egg cytoplasm contracts producing a clear separation from the vitelline membrane and empty spaces at the anterior and posterior. The cleavage nuclei migrate towards the periphery. Duration at 25 degrees C approximately 40 minutes (25-65 minutes AEL)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 70.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005290 ! substage of pre-blastoderm stage
relationship: RO:0002087 FBdv:00005291 ! immediately preceded by embryonic stage 1
[Term]
id: FBdv:00005294
name: embryonic cycle 2
def: "The second mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 60.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005293 ! substage of embryonic stage 2
relationship: RO:0002087 FBdv:00005292 ! immediately preceded by embryonic cycle 1
[Term]
id: FBdv:00005295
name: embryonic cycle 3
def: "The third mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 80.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005293 ! substage of embryonic stage 2
relationship: RO:0002087 FBdv:00005291 ! immediately preceded by embryonic stage 1
relationship: RO:0002087 FBdv:00005294 ! immediately preceded by embryonic cycle 2
[Term]
id: FBdv:00005296
name: embryonic cycle 4
def: "The fourth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 90.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005293 ! substage of embryonic stage 2
relationship: RO:0002087 FBdv:00005295 ! immediately preceded by embryonic cycle 3
[Term]
id: FBdv:00005297
name: embryonic cycle 5
def: "The fifth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 100.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005293 ! substage of embryonic stage 2
relationship: RO:0002087 FBdv:00005296 ! immediately preceded by embryonic cycle 4
[Term]
id: FBdv:00005298
name: embryonic cycle 6
def: "The sixth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 110.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005293 ! substage of embryonic stage 2
relationship: RO:0002087 FBdv:00005297 ! immediately preceded by embryonic cycle 5
[Term]
id: FBdv:00005299
name: embryonic cycle 7
def: "The seventh mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 120.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005293 ! substage of embryonic stage 2
relationship: RO:0002087 FBdv:00005298 ! immediately preceded by embryonic cycle 6
[Term]
id: FBdv:00005300
name: embryonic cycle 8
def: "The eighth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 130.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005293 ! substage of embryonic stage 2
relationship: RO:0002087 FBdv:00005299 ! immediately preceded by embryonic cycle 7
[Term]
id: FBdv:00005301
name: embryonic stage 3
def: "Nuclear division 9. The cleavage nuclei complete their migration to the periphery. Polar buds form at the posterior pole and divide once. Duration at 25 degrees C: approximately 15 minutes (65-80 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 140.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005290 ! substage of pre-blastoderm stage
relationship: RO:0002087 FBdv:00005293 ! immediately preceded by embryonic stage 2
relationship: RO:0002087 FBdv:00005300 ! immediately preceded by embryonic cycle 8
[Term]
id: FBdv:00005302
name: embryonic cycle 9
def: "The ninth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 150.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005301 ! substage of embryonic stage 3
relationship: RO:0002087 FBdv:00005293 ! immediately preceded by embryonic stage 2
relationship: RO:0002087 FBdv:00005300 ! immediately preceded by embryonic cycle 8
[Term]
id: FBdv:00005303
name: embryonic cycle 10
def: "The tenth mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 180.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005306 ! substage of embryonic stage 4
relationship: RO:0002087 FBdv:00005301 ! immediately preceded by embryonic stage 3
relationship: RO:0002087 FBdv:00005302 ! immediately preceded by embryonic cycle 9
[Term]
id: FBdv:00005304
name: blastoderm stage
def: "Stage during which most of the nuclei are arranged as a monolayer at the cortex (periphery) of the embryo (Foe and Alberts, 1983; Jaeger et al., 2012). It begins shortly after completion of the ninth cleavage division and lasts until the onset of gastrulation, including cleavage cycles 10-14A (Foe and Alberts, 1983; Jaeger et al., 2012). This corresponds to embryonic stages 4 (syncitial blastoderm stage) and 5 (cellular blastoderm stage) (Campos-Ortega and Hartenstein, 1997)." [FlyBase:FBrf0039741, FlyBase:FBrf0089570, FlyBase:FBrf0220623]
comment: Temporal ordering number - 160.
synonym: "blastoderm" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00005290 ! immediately preceded by pre-blastoderm stage
relationship: RO:0002087 FBdv:00005301 ! immediately preceded by embryonic stage 3
[Term]
id: FBdv:00005305
name: obsolete syncytial blastoderm stage
is_obsolete: true
[Term]
id: FBdv:00005306
name: embryonic stage 4
def: "Nuclear division 10-13. Polar buds divide twice and become tightly grouped at the posterior pole by the end of this stage. Nuclei visible at the rim of the embryo. Stage 4 ends with the beginning of cellularization. Duration at 25 degrees C: approximately 50 minutes (80-130 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 170.
synonym: "syncytial blastoderm stage" EXACT [FlyBase:FBrf0089570]
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005304 ! substage of blastoderm stage
relationship: RO:0002087 FBdv:00005290 ! immediately preceded by pre-blastoderm stage
relationship: RO:0002087 FBdv:00005301 ! immediately preceded by embryonic stage 3
relationship: RO:0002087 FBdv:00005302 ! immediately preceded by embryonic cycle 9
[Term]
id: FBdv:00005307
name: embryonic cycle 11
def: "The 11th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 185.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005306 ! substage of embryonic stage 4
relationship: RO:0002087 FBdv:00005303 ! immediately preceded by embryonic cycle 10
[Term]
id: FBdv:00005308
name: embryonic cycle 12
def: "The 12th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 190.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005306 ! substage of embryonic stage 4
relationship: RO:0002087 FBdv:00005307 ! immediately preceded by embryonic cycle 11
[Term]
id: FBdv:00005309
name: embryonic cycle 13
def: "The 13th mitotic cell cycle of embryogenesis. This occurs synchronously across the embryo." [FlyBase:FBrf0049535]
comment: Temporal ordering number - 200.
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005306 ! substage of embryonic stage 4
relationship: RO:0002087 FBdv:00005308 ! immediately preceded by embryonic cycle 12
[Term]
id: FBdv:00005310
name: obsolete cellular blastoderm stage
is_obsolete: true
[Term]
id: FBdv:00005311
name: embryonic stage 5
def: "Cellularization. Stage 5 begins when cellularization starts. Near the end of this stage the pole cells begin to migrate dorsally and ventral midline cells acquire an irregular, wavy appearance. Stage 5 ends when ventral furrow formation becomes apparent. Duration at 25 degrees: approximately 40 minutes (130-170 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 210.
synonym: "cellular blastoderm stage" EXACT [FlyBase:FBrf0089570]
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005304 ! substage of blastoderm stage
relationship: RO:0002087 FBdv:00000054 ! immediately preceded by cleavage stage
relationship: RO:0002087 FBdv:00005306 ! immediately preceded by embryonic stage 4
[Term]
id: FBdv:00005312
name: embryonic cycle 14
def: "The 14th mitotic cell cycle of embryogenesis. This is the first round of nuclear division to occur in a cellularized embryo, so this is the first round of cell division. Embryonic cycle 14 mitosis is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains." [FlyBase:FBrf0049535, FlyBase:FBrf0089570]
comment: Temporal ordering number - 255. The asynchronous nature of cycle 14 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.
synonym: "first blastoderm mitosis" EXACT [FlyBase:FBrf0089570]
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
[Term]
id: FBdv:00005313
name: embryonic cycle 14A
def: "The interphase of embryonic cycle 14. This begins at the same time as cellularization and is of variable length depending on cell identity: embryonic cycle 14 M phase (14B) is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains." [FlyBase:FBrf0039741]
comment: Temporal ordering number - 256.
synonym: "embryonic cycle 14 interphase" EXACT [FBC:DOS]
is_a: FBdv:00007022 ! embryonic cycle interphase
relationship: FBdv:00018001 FBdv:00005312 ! substage of embryonic cycle 14
[Term]
id: FBdv:00005314
name: embryonic cycle 14B
def: "The M-phase of embryonic cycle 14. This is asynchronous across the embryo, but occurs synchronously within discrete domains, known as mitotic domains." [FlyBase:FBrf0039741]
comment: Temporal ordering number - 257. Not to be confused with mitotic domain 14B, which is a domain of cells in the dorsal midline of the head that don't undergo a 14th division (Foe, 1989). The asynchronous nature of cycle 14 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.
synonym: "embryonic cycle 14 M-phase" EXACT [FBC:DOS]
is_a: FBdv:00007023 ! embryonic cycle M-phase
relationship: FBdv:00018001 FBdv:00005312 ! substage of embryonic cycle 14
[Term]
id: FBdv:00005315
name: embryonic cycle 15
def: "The 15th cell cycle of embryogenesis. Asynchronous." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 285. The asynchronous nature of cycle 15 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.
synonym: "second blastoderm mitosis" EXACT [FlyBase:FBrf0089570]
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00005312 ! immediately preceded by embryonic cycle 14
[Term]
id: FBdv:00005316
name: embryonic cycle 16
def: "The 16th cell cycle division of embryogenesis. Asynchronous." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 295. The asynchronous nature of cycle 16 divisions means that this is not very useful for annotating stage. If possible a standard embryonic stage should be used instead.
synonym: "third blastoderm mitosis" EXACT [FlyBase:FBrf0089570]
is_a: FBdv:00007011 ! embryonic cycle
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00005315 ! immediately preceded by embryonic cycle 15
[Term]
id: FBdv:00005317
name: gastrula stage
def: "Stage during which gastrulation occurs. During this stage, cells from the polar caps and the mid-ventral part of the blastoderm invaginate and ultimately generate the germ layers (Hartenstein, 1993). This encompasses embryonic stages 6-8 (Hartenstein, 1993)." [FlyBase:FBrf0064803]
comment: Temporal ordering number - 220.
synonym: "gastrula" EXACT []
synonym: "gastrulation stage" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00005304 ! immediately preceded by blastoderm stage
relationship: RO:0002087 FBdv:00005311 ! immediately preceded by embryonic stage 5
[Term]
id: FBdv:00005318
name: embryonic stage 6
def: "Stage 6 begins when the ventral furrow becomes apparent, an event which is followed rapidly by the formation of the cephalic furrow. Stage 6 ends when the pole cells have adopted a dorsal (horizontal) position at the posterior. Duration at 25 degrees C: approximately 10 minutes (170-180 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 230.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005317 ! substage of gastrula stage
relationship: RO:0002087 FBdv:00005304 ! immediately preceded by blastoderm stage
relationship: RO:0002087 FBdv:00005311 ! immediately preceded by embryonic stage 5
[Term]
id: FBdv:00005319
name: embryonic stage 7
def: "Stage 7 begins when the pole cells have adopted a dorsal (horizontal) position at the posterior. Invagination of the anterior and posterior midgut and hindgut follows. The 'discoid plate' that carries the pole cells forms a pocket. Transverse furrows (dorsal folds) form on the dorsal surface. This stage ends when the anterior wall of the amnioproctodeal invagination starts moving anteriorly and the pole cells are no longer visible externally. Duration at 25 degrees C: approximately 10 minutes (180-190 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 240.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005317 ! substage of gastrula stage
relationship: RO:0002087 FBdv:00005318 ! immediately preceded by embryonic stage 6
[Term]
id: FBdv:00005320
name: obsolete germ band stage
is_obsolete: true
[Term]
id: FBdv:00005321
name: extended germ band stage
def: "Stages during which the germ band is extended - 9-12." [FBC:DOS, FlyBase:FBrf0229323]
comment: Temporal ordering number - 260.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00005317 ! immediately preceded by gastrula stage
relationship: RO:0002087 FBdv:00005322 ! immediately preceded by embryonic stage 8
[Term]
id: FBdv:00005322
name: embryonic stage 8
def: "Stage 8 starts with the rapid phase of germ band extension and ends with the beginning of mesodermal segmentation. By the end of this stage germ band extension has progressed to the point where the proctodeal opening is at about 60% egg length and the dorsal folds (transverse furrows) are no longer visible. Duration at 25 degrees C: approximately 30 minutes (190-220 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 250.
synonym: "rapidly extending germ band stage" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005317 ! substage of gastrula stage
relationship: RO:0002087 FBdv:00005319 ! immediately preceded by embryonic stage 7
[Term]
id: FBdv:00005323
name: embryonic stage 9
def: "Stage 9 begins when mesodermal segmentation becomes (transiently) visible, and ends with the appearance of the stomodeal invagination slightly ventral to the anterior pole. Duration at 25 degrees C: approximately 40 minutes (220-260 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 280.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00014201 ! substage of early extended germ band stage
relationship: RO:0002087 FBdv:00005317 ! immediately preceded by gastrula stage
relationship: RO:0002087 FBdv:00005322 ! immediately preceded by embryonic stage 8
[Term]
id: FBdv:00005324
name: embryonic stage 10
def: "Stage 10 begins with the appearance of the stomodeal invagination, slightly ventral to the anterior pole. Periodic furrows appear in the embryonic epidermis around the middle of the stage. The germ band continues to extend, reaching its maximum extent of 75% egg length towards the end of the stage. The end of the stage is marked by the beginning of invagination of the tracheal placodes. Duration at 25 degrees : approximately 60 minutes (260-320 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 290.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00014201 ! substage of early extended germ band stage
relationship: RO:0002087 FBdv:00005323 ! immediately preceded by embryonic stage 9
[Term]
id: FBdv:00005325
name: embryonic stage 11
def: "Stage 11 begins with the invagination of the tracheal placodes. Para-segmental furrow form and segment boundary furrows become deep folds. Within the head, gnathal protuberances become apparent. The end of this stage is signaled by the appearance of a distinct cleft at the posterior pole of the embryo, which becomes detached from the vitelline membrane. This marks the beginning of germ-band retraction. Duration at 25 degrees C: approximately 120 minutes (320-440 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 310.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004450 ! substage of late extended germ band stage
relationship: RO:0002087 FBdv:00005324 ! immediately preceded by embryonic stage 10
relationship: RO:0002087 FBdv:00014201 ! immediately preceded by early extended germ band stage
[Term]
id: FBdv:00005326
name: obsolete contracted germ band stage
is_obsolete: true
[Term]
id: FBdv:00005327
name: embryonic stage 12
def: "Germ band retraction. Stage 12 begins when germ-band retraction starts and ends when this process is complete so that the prospective anal plate occupies the posterior pole. During this stage the posterior and anterior midgut primordia meet and fuse and the tracheal pits fuse to form the tracheal tree. Duration at 25 degrees C: approximately 120 minutes (440-560 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 320.
synonym: "retracting germ band stage" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00004450 ! substage of late extended germ band stage
relationship: RO:0002087 FBdv:00005325 ! immediately preceded by embryonic stage 11
[Term]
id: FBdv:00005328
name: embryonic stage 13
def: "Stage 13 begins at the completion of germ-band retraction, when the prospective anal plate occupy the posterior pole. The dorsal ridge becomes apparent externally; the clypeolabrum retracts, leaving a triangular shaped gap at the anterior pole; the labium moves to the ventral midline. This stage ends when head involution begins. Duration at 25 degrees C: Approximately 60 minutes (560-620 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 340.
synonym: "contracted germ band stage" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005331 ! substage of dorsal closure stage
relationship: RO:0002087 FBdv:00004450 ! immediately preceded by late extended germ band stage
relationship: RO:0002087 FBdv:00005321 ! immediately preceded by extended germ band stage
relationship: RO:0002087 FBdv:00005327 ! immediately preceded by embryonic stage 12
[Term]
id: FBdv:00005329
name: obsolete head involution stage
is_obsolete: true
replaced_by: FBdv:00005330
[Term]
id: FBdv:00005330
name: embryonic stage 14
def: "Stage 14 begins with the initiation of head involution. Closure of the midgut around the yolk and dorsal closure continue. Dorsal closure is 80% complete by the end of this stage. This stage ends with the appearance of the second midgut constriction. Duration at 25 degrees C: approximately 60 minutes (620-680 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 350.
synonym: "head involution stage" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005331 ! substage of dorsal closure stage
relationship: RO:0002087 FBdv:00005328 ! immediately preceded by embryonic stage 13
[Term]
id: FBdv:00005331
name: dorsal closure stage
def: "Stage following germ band retraction, during which dorsal closure happens (Hartenstein, 1993). Dorsal closure occurs by extension of the dorsal epidermal primordium on either side, leading to fusion at the dorsal midline (Campos-Ortega and Hartenstein, 1997). This corresponds to embryonic stages 13-15 (Hartenstein, 1993; Campos-Ortega and Hartenstein, 1997)." [FlyBase:FBrf0064803, FlyBase:FBrf0089570]
comment: Temporal ordering number - 330.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00004450 ! immediately preceded by late extended germ band stage
relationship: RO:0002087 FBdv:00005321 ! immediately preceded by extended germ band stage
relationship: RO:0002087 FBdv:00005327 ! immediately preceded by embryonic stage 12
[Term]
id: FBdv:00005332
name: embryonic stage 15
def: "Stage 15 begins with the appearance of the second midgut constriction. During this stage the 1st and 3rd midgut constrictions form, dorsal closure is completed, and epidermal segmentation is accomplished. This stage ends when the intersegmental grooves can be distinguished at mid-dorsal level. Duration at 25 degrees C: approximately 100 minutes (680-780 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 360.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005331 ! substage of dorsal closure stage
relationship: RO:0002087 FBdv:00005330 ! immediately preceded by embryonic stage 14
[Term]
id: FBdv:00005333
name: late embryonic stage
def: "Embryonic stages 16-17." [FBC:DOS]
comment: Temporal ordering number - 370.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005289 ! substage of embryonic stage
relationship: RO:0002087 FBdv:00005331 ! immediately preceded by dorsal closure stage
relationship: RO:0002087 FBdv:00005332 ! immediately preceded by embryonic stage 15
[Term]
id: FBdv:00005334
name: embryonic stage 16
def: "Stage 16 begins when the intersegmental grooves can be distinguished at mid-dorsal level, and ends when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. During this stage the ventral cord retracts to about 60% egg length. Duration at 25 degrees C: approximately 180 minutes (780-960 minutes after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 380.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005333 ! substage of late embryonic stage
relationship: RO:0002087 FBdv:00005331 ! immediately preceded by dorsal closure stage
relationship: RO:0002087 FBdv:00005332 ! immediately preceded by embryonic stage 15
[Term]
id: FBdv:00005335
name: embryonic stage 17
def: "Stage 17 begins when the dorsal ridge (frontal sac) has overgrown the tip of the clypeolabrum, which is thereby enclosed in the atrium. It lasts until hatching of the embryo (approximately 24 hours after egg laying), during which time much terminal differentiation occurs, the tracheal tree fills with air, so becoming completely visible, and the ventral cord continues to retract. Duration at 25 degrees C: approximately 8 hours (16-24 hours after egg laying)." [FlyBase:FBrf0089570]
comment: Temporal ordering number - 390.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005333 ! substage of late embryonic stage
relationship: RO:0002087 FBdv:00005334 ! immediately preceded by embryonic stage 16
[Term]
id: FBdv:00005336
name: larval stage
def: "The stage of the Drosophila life-cycle from hatching to the beginning of puparium formation." [FBC:DOS]
comment: Temporal ordering number - 400.
is_a: FBdv:00007012 ! life stage
relationship: RO:0002087 FBdv:00005289 ! immediately preceded by embryonic stage
relationship: RO:0002087 FBdv:00005335 ! immediately preceded by embryonic stage 17
relationship: RO:0002087 FBdv:00007018 ! immediately preceded by embryonic stage 17(iv)
relationship: RO:0002090 FBdv:00005342 ! immediately precedes prepupal stage
relationship: RO:0002090 FBdv:00007001 ! immediately precedes P-stage
[Term]
id: FBdv:00005337
name: first instar larval stage
def: "The first larval instar begins at hatching and ends at the first larval molt. Anterior spiracles are not yet present; posterior spiracles have two openings each. Salivary glands are very small and all cells are uniform in size. Mouth hooks typically have one tooth. Duration at 25 degrees C: approximately 25 hours (24-49 hours after egg laying; 0-25 hours after hatching)." [FlyBase:FBrf0007733]
comment: Temporal ordering number - 410.
synonym: "first instar larva" EXACT []
synonym: "L1" EXACT []
xref: UBERON:8000000
is_a: FBdv:00007012 ! life stage
relationship: FBdv:00018001 FBdv:00005336 ! substage of larval stage
relationship: RO:0002087 FBdv:00005289 ! immediately preceded by embryonic stage
relationship: RO:0002087 FBdv:00005333 ! immediately preceded by late embryonic stage
relationship: RO:0002087 FBdv:00005335 ! immediately preceded by embryonic stage 17
relationship: RO:0002087 FBdv:00007018 ! immediately preceded by embryonic stage 17(iv)
relationship: RO:0002090 FBdv:00005338 ! immediately precedes second instar larval stage
[Term]
id: FBdv:00005338
name: second instar larval stage
def: "The second larval instar begins at the first larval molt and ends at the second larval molt. Larvae are actively feeding and crawling in the food. Distinct anterior spiracles are present as enlargements at the end of the tracheal trunk, but not open to the outside; posterior spiracles have three openings each, and four groups of small unbranched hairs. The salivary glands extend to the first abdominal segment, and have cells that are uniform in size. Mouth hooks typically have two or three teeth. Duration at 25 degrees C: approximately 23 hours (49-72 hours after egg laying; 25-48 hours after hatching)." [FlyBase:FBrf0007733]
comment: Temporal ordering number - 420.
synonym: "L2" EXACT []
synonym: "second instar larva" EXACT []
xref: UBERON:8000001
is_a: FBdv:00007012 ! life stage
relationship: FBdv:00018001 FBdv:00005336 ! substage of larval stage
relationship: RO:0002087 FBdv:00005337 ! immediately preceded by first instar larval stage
relationship: RO:0002090 FBdv:00005339 ! immediately precedes third instar larval stage
[Term]
id: FBdv:00005339
name: third instar larval stage
def: "The third larval instar begins at the second larval molt and ends at puparium formation. Anterior spiracles are open to the outside; posterior spiracles have three openings each, and four groups of large branched hairs. The salivary glands extend to the second abdominal segment, with cells larger in the posterior than in the anterior of the gland. Mouth hooks typically have 9-12 teeth. About 24 hours before pupariation (at 25 degree C), larvae stop feeding and climb away from their food. Duration at 25 degrees C: approximately 48 hours (72-120 hours after egg laying; 48-96 hours after hatching)." [FlyBase:FBrf0007733]
comment: Temporal ordering number - 430.
synonym: "L3" EXACT []
synonym: "third instar larva" RELATED []
xref: UBERON:8000002
is_a: FBdv:00007012 ! life stage
relationship: FBdv:00018001 FBdv:00005336 ! substage of larval stage
relationship: RO:0002087 FBdv:00005338 ! immediately preceded by second instar larval stage
relationship: RO:0002090 FBdv:00005342 ! immediately precedes prepupal stage
relationship: RO:0002090 FBdv:00007001 ! immediately precedes P-stage
[Term]
id: FBdv:00005340
name: early third instar larval stage
def: "Third instar larva prior to the wandering stage (approximately the first 24 hours of the third instar larval stage under standard conditions at 25'C.)." [FlyBase:FBrf0049147]
comment: Temporal ordering number - 440.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005339 ! substage of third instar larval stage
relationship: RO:0002087 FBdv:00005338 ! immediately preceded by second instar larval stage
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2008-11-13T11:51:56Z" xsd:string
[Term]
id: FBdv:00005341
name: wandering third instar larval stage
def: "Stage of the third larval instar during which the larva wanders out of the food and climbs. Under optimum conditions at 25'C, this occurs approximately 24 hours after the start of the third instar larval stage." [FlyBase:FBrf0049147]
comment: Temporal ordering number - 460.
synonym: "late third instar" BROAD []
synonym: "post-feeding larva" BROAD []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00007007 ! substage of late third instar larval stage
relationship: RO:0002087 FBdv:00005340 ! immediately preceded by early third instar larval stage
property_value: http://purl.org/dc/terms/contributor http://orcid.org/0000-0002-7073-9172
property_value: http://purl.org/dc/terms/date "2008-11-13T11:55:46Z" xsd:string
[Term]
id: FBdv:00005342
name: prepupal stage
def: "The prepupal stage begins at puparium formation and ends when larval/pupal apolysis is complete, as indicated by the completion of imaginal head sac eversion and the expulsion of the oral armature of the larva. Duration at 25 degrees C: approximately 12 hours. (120-132.2 hours after egg laying; 0-12.2 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 500.
is_a: FBdv:00007012 ! life stage
relationship: FBdv:00018001 FBdv:00007001 ! substage of P-stage
relationship: RO:0002087 FBdv:00005336 ! immediately preceded by larval stage
relationship: RO:0002087 FBdv:00005339 ! immediately preceded by third instar larval stage
relationship: RO:0002087 FBdv:00007005 ! immediately preceded by third instar larval stage L2
relationship: RO:0002087 FBdv:00007007 ! immediately preceded by late third instar larval stage
relationship: RO:0002090 FBdv:00005349 ! immediately precedes pupal stage
[Term]
id: FBdv:00005343
name: prepupal stage P1
def: "Extends from puparium formation through tanning of the pupal cuticle. Posterior spiracles and ridge between anterior spiracles tan orange. Wriggling stops completely. Puparium becomes brown to the unaided eye. Duration at 25 degrees C: approximately 20 minutes. (120-120.3 hours after egg laying; 0-0.3 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 510.
synonym: "pupal stage P0" NARROW [FlyBase:FBrf0036849]
synonym: "pupal stage P1" EXACT []
synonym: "puparium formation" EXACT [FlyBase:FBrf0036849]
synonym: "white prepupa" NARROW [FlyBase:FBrf0036849]
synonym: "white puparium stage" EXACT [FlyBase:FBrf0036849]
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005342 ! substage of prepupal stage
relationship: RO:0002087 FBdv:00005336 ! immediately preceded by larval stage
relationship: RO:0002087 FBdv:00005339 ! immediately preceded by third instar larval stage
relationship: RO:0002087 FBdv:00007005 ! immediately preceded by third instar larval stage L2
relationship: RO:0002087 FBdv:00007007 ! immediately preceded by late third instar larval stage
[Term]
id: FBdv:00005344
name: prepupal stage P2
def: "Male gonads become less distinct. Oral armature stops moving permanently. Dorsal medial abdominal contractions stop. Gas bubble becomes visible within abdomen. Duration at 25 degrees C: approximately 100 minutes. (120.3-122 hours after egg laying; 0.3-2 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 520.
synonym: "brown puparium stage" EXACT [FlyBase:FBrf0036849]
synonym: "pupal stage P2" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005342 ! substage of prepupal stage
relationship: RO:0002087 FBdv:00005343 ! immediately preceded by prepupal stage P1
[Term]
id: FBdv:00005345
name: prepupal stage P3
def: "Ridge of the operculum becomes distinct. Puparium begins to separate from underlying epidermis. Becomes positively buoyant. Duration at 25 degrees C: approximately 4 hours, 45 minutes. (122-126.75 hours after egg laying; 2-6.75 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 530.
synonym: "bubble prepupa stage" EXACT [FlyBase:FBrf0036849]
synonym: "pupal stage P3" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005342 ! substage of prepupal stage
relationship: RO:0002087 FBdv:00005344 ! immediately preceded by prepupal stage P2
[Term]
id: FBdv:00005346
name: prepupal stage P4
def: "Prepupal stage P4 begins as the lateral trunk trachea become obscured and ends when the imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 5 hours, 30 minutes. (126.75-132.2 hours after egg laying; 6.75-12.2 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 540.
synonym: "cryptocephalic pupa" EXACT [FlyBase:FBrf0036849]
synonym: "pupal stage P4" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005342 ! substage of prepupal stage
relationship: RO:0002087 FBdv:00005345 ! immediately preceded by prepupal stage P3
[Term]
id: FBdv:00005347
name: prepupal stage P4(i)
def: "Lateral trunk tracheae become obscured. Dorsal medial abdominal contractions occur. Everted leg and wing discs become visible. Bubble appears in posterior of puparium, displacing the pupa anteriorly; abdominal bubble disappears. Duration at 25 degrees C: approximately 5 hours, 15 minutes. (126.75-132 hours after egg laying; 6.75-12 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 550.
synonym: "buoyant stage" EXACT [FlyBase:FBrf0036849]
synonym: "pupal stage P4(i)" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005346 ! substage of prepupal stage P4
relationship: RO:0002087 FBdv:00005345 ! immediately preceded by prepupal stage P3
[Term]
id: FBdv:00005348
name: prepupal stage P4(ii)
def: "Bubble is displaced to anterior end of the puparium, and pupa withdraws to the posterior end. Imaginal head sac is everted and the oral armature of the larva is expelled. Duration at 25 degrees C: approximately 12 minutes. (132-132.2 hours after egg laying; 12-12.2 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 560.
synonym: "moving bubble stage" EXACT [FlyBase:FBrf0036849]
synonym: "pupal stage P4(ii)" EXACT []
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005346 ! substage of prepupal stage P4
relationship: RO:0002087 FBdv:00005347 ! immediately preceded by prepupal stage P4(i)
[Term]
id: FBdv:00005349
name: pupal stage
def: "The pupal stage starts once larval/pupal apolysis is complete as indicated by the expulsion of the larval armature. Early in this stage, the legs and wings reach full extension along the abdomen. The stage ends when the pupal cuticle separates from the underlying epidermis (pupal/adult apolysis), and the eye cup becomes yellow at its periphery. Duration at 25 degrees C: approximately 32 hours. (132.2-164.3 hours after egg laying; 12.2-44.3 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 570. DISAMBIGUATION: In Drosophila lab vernacular, the term 'pupal stage' is often used to refer to the entire period from formation of the puparium to eclosion. However, this does not correspond to the standard usage of 'pupal stage' for Cyclorrhaphous flies (for discussion see: FBrf0087128). Briefly: formation of the puparium (hardening of the larval cuticle) marks the beginning of the pre-pupal stage. The pupal stage begins following pupal/larval apolysis - detachment of the larval epidermis from the puparium. In Drosophila, the outward sign of the completion of apolysis is the eversion of the head and expulsion of the larval mouthparts (FBrf0036849). We use P-stage to refer to the stage from pupariation to eclosion, and restrict pupal stage to its standard usage.
synonym: "phanerocephalic pupa" EXACT [FlyBase:FBrf0036849]
is_a: FBdv:00007012 ! life stage
relationship: FBdv:00018001 FBdv:00007001 ! substage of P-stage
relationship: RO:0002087 FBdv:00005342 ! immediately preceded by prepupal stage
relationship: RO:0002090 FBdv:00006011 ! immediately precedes pharate adult stage
[Term]
id: FBdv:00005350
name: pupal stage P5
def: "Pupal stage P5 starts when the legs and wings reach full extension along the abdomen and ends as the Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 6 hours, 30 minutes. (132.2-138.7 hours after egg laying; 12.2-18.7 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 580.
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005349 ! substage of pupal stage
relationship: RO:0002087 FBdv:00005342 ! immediately preceded by prepupal stage
relationship: RO:0002087 FBdv:00005346 ! immediately preceded by prepupal stage P4
relationship: RO:0002087 FBdv:00005348 ! immediately preceded by prepupal stage P4(ii)
[Term]
id: FBdv:00005351
name: pupal stage P5(i)
def: "Legs and wings reach full extension along abdomen. Enlarged initial segments of anterior pair Malpighian tubules move from thorax into abdomen. Translucent patch that lacks adhering fat body cells becomes discernible in the middle of the eye region. Pair of white Malpighian tubules becomes visible dorsally in the abdomen. Duration at 25 degrees C: approximately 66 minutes. (132.2-133.3 hours after egg laying; 12.2-13.3 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 590.
synonym: "Malpighian tubules migrating" EXACT [FlyBase:FBrf0036849]
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005350 ! substage of pupal stage P5
relationship: RO:0002087 FBdv:00005346 ! immediately preceded by prepupal stage P4
relationship: RO:0002087 FBdv:00005348 ! immediately preceded by prepupal stage P4(ii)
[Term]
id: FBdv:00005352
name: pupal stage P5(ii)
def: "Malpighian tubules become prominent and green. Duration at 25 degrees C: approximately 5 hours, 25 minutes. (133.3-138.7 hours after egg laying; 13.3-18.7 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 600.
synonym: "white Malpighian tubules stage" EXACT [FlyBase:FBrf0036849]
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005350 ! substage of pupal stage P5
relationship: RO:0002087 FBdv:00005351 ! immediately preceded by pupal stage P5(i)
[Term]
id: FBdv:00005353
name: pupal stage P6
def: "Dark green 'yellow body' appears between the anterior ends of the two Malpighian tubule segments, mid-dorsally at the anterior of the abdomen. Duration at 25 degrees C: approximately 13 hours, 45 minutes. (138.7-152.4 hours after egg laying; 18.7-32.4 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 610.
synonym: "green Malpighian tubules stage" EXACT [FlyBase:FBrf0036849]
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005349 ! substage of pupal stage
relationship: RO:0002087 FBdv:00005350 ! immediately preceded by pupal stage P5
relationship: RO:0002087 FBdv:00005352 ! immediately preceded by pupal stage P5(ii)
[Term]
id: FBdv:00005354
name: pupal stage P7
def: "The 'yellow body' moves back between the Malpighian tubules. The transparent pupal cuticle separates from the underlying epidermis. Eye cup becomes yellow at its perimeter. Duration at 25 degrees C: approximately 12 hours. (152.4-164.3 hours after egg laying; 32.4-44.3 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 620.
synonym: "yellow body stage" EXACT [FlyBase:FBrf0036849]
is_a: FBdv:00005259 ! developmental stage
relationship: FBdv:00018001 FBdv:00005349 ! substage of pupal stage
relationship: RO:0002087 FBdv:00005353 ! immediately preceded by pupal stage P6
[Term]
id: FBdv:00005355
name: pharate adult stage P8
def: "Pale yellow pigmentation spreads inwards across the eye. Eye color becomes bright yellow, then changes to amber. Duration at 25 degrees C: approximately 12 hours 20 minutes. (164.3-176.6 hours after egg laying; 44.3-56.6 hours after puparium formation)." [FlyBase:FBrf0036849, FlyBase:FBrf0048355]
comment: Temporal ordering number - 630.